目的研究突变型人胰高血糖素样肽-1(mutated human glucagon-like peptide-1,mGLP-1)对谷氨酸诱导的人神经母细胞瘤细胞SH-SY5Y细胞损伤的影响。方法环磷酸腺苷(cAMP)试剂盒检测细胞内cAMP含量,比较mGLP-1和天然人胰高血糖素样肽-1(natu...
supported by thegrants from National Natural Science Foundation of China(No. 30870790);Shanghai Science and Technology Commis-sion (No. 06DZ19003);in part by National Basic ResearchDevelopment Program (973) of China (No. 2009CB918402)
Objective To investigate the mechanisms of excitotoxic effects of glutamate on human neuroblastoma SH-SY5Y cells. Methods SH-SY5Y cell viability was measured by MTT assay. Other damaged profile was detected by lactate...
supported by the grants from Shanghai Science and Technology Commission (06DZ19003);National Natural Science Foundation of China (30870790);supported in part by 973 Project (2009CB918402)
Objective This report aims to describe the oxidative damage profile in brain ofpresenilinl andpresenilin2 conditional double knockout mice (dKO) at both early and late age stages, and to discuss the correlation betw...