国家自然科学基金(30870790)

作品数:3被引量:5H指数:2
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相关作者:孙中伟张蓝梅兵竺淑佳陈温纯更多>>
相关机构:华东师范大学更多>>
相关期刊:《Neuroscience Bulletin》《中国现代应用药学》更多>>
相关主题:GLUTAMATEEFFECTSEXCITOTOXICITYVIA胞内钙离子更多>>
相关领域:医药卫生更多>>
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突变型人胰高血糖素样肽-1对神经细胞损伤的保护被引量:2
《中国现代应用药学》2012年第3期185-191,共7页张蓝 孙中伟 黄刚 黄静 孟博 徐敏华 
国家自然科学基金资助项目(30870790)
目的研究突变型人胰高血糖素样肽-1(mutated human glucagon-like peptide-1,mGLP-1)对谷氨酸诱导的人神经母细胞瘤细胞SH-SY5Y细胞损伤的影响。方法环磷酸腺苷(cAMP)试剂盒检测细胞内cAMP含量,比较mGLP-1和天然人胰高血糖素样肽-1(natu...
关键词:谷氨酸中毒 突变型人胰高血糖素样肽-1 胞内钙离子 氧化损伤 神经母细胞瘤细胞 
Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage被引量:3
《Neuroscience Bulletin》2010年第1期8-16,共9页孙中伟 张蓝 竺淑佳 陈温纯 梅兵 
supported by thegrants from National Natural Science Foundation of China(No. 30870790);Shanghai Science and Technology Commis-sion (No. 06DZ19003);in part by National Basic ResearchDevelopment Program (973) of China (No. 2009CB918402)
Objective To investigate the mechanisms of excitotoxic effects of glutamate on human neuroblastoma SH-SY5Y cells. Methods SH-SY5Y cell viability was measured by MTT assay. Other damaged profile was detected by lactate...
关键词:GLUTAMATE EXCITOTOXICITY cytosolic calcium oxidative damage 
Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice
《Neuroscience Bulletin》2009年第3期131-137,共7页张冬丽 陈逸群 姜旭 嵇婷婷 梅兵 
supported by the grants from Shanghai Science and Technology Commission (06DZ19003);National Natural Science Foundation of China (30870790);supported in part by 973 Project (2009CB918402)
Objective This report aims to describe the oxidative damage profile in brain ofpresenilinl andpresenilin2 conditional double knockout mice (dKO) at both early and late age stages, and to discuss the correlation betw...
关键词:PRESENILINS Alzheimer's disease oxidative damage 8-OHDG 
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