PRESENILINS

作品数：8被引量：36H指数：3
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相关作者：刘国灿梅兵鲍云鹤邹泉郑坚瑜更多>>
相关机构：华东师范大学南开大学中国人民解放军第一军医大学北京大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Translational Neurodegeneration》《生命科学》更多>>
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Sex effect on presenilins expression in post-natal rat brain
《Advances in Bioscience and Biotechnology》2013年第12期1086-1094,共9页Paola Piscopo Sonia Canterini Valentina Carletti Paolo Rosa Alessio Crestini Maria Teresa Fiorenza Annamaria Confaloni 
Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is r...
关键词：Development SEX PRESENILINS Γ-SECRETASE Rats Sexual DIMORPHISM 
Presenilins条件性双基因敲除小鼠海马与皮层超微结构的增龄性变化
《复旦学报（自然科学版）》2013年第4期472-478,共7页李莉 刘国灿 梅兵 章平 倪兵 
上海市科委重点项目(10JC1411200)
为研究Presenilins条件性双基因敲除对于小鼠海马与皮层超微结构的影响,选用3、6及12月龄Presenilins 1/Presenilins 2双敲除小鼠(dKO)和同窝对照小鼠(CON),运用透射电子显微镜技术,分别观察海马与皮层突触、细胞核、线粒体、溶酶体超...
关键词：PRESENILINS 条件性双基因敲除小鼠 超微结构 
Advances in the pathogenesis of Alzheimer’s disease:a re-evaluation of amyloid cascade hypothesis被引量：13
《Translational Neurodegeneration》2012年第1期140-151,共12页Suzhen Dong Yale Duan Yinghe Hu Zheng Zhao 
This work was supported by the grants from the National Natural Science Foundation of China(No.31171019,No.81173108 and No.31000574);the Opening Projects of Shanghai Key Laboratory of Brain Functional Genomics and Key Laboratory of Brain Functional Genomics(East China Normal University),Ministry of Education.
Alzheimer’s disease(AD)is a common neurodegenerative disease characterized clinically by progressive deterioration of memory,and pathologically by histopathological changes including extracellular deposits of amyloid...
关键词：Alzheimer’s disease A-BETA APP BACE1 PRESENILINS ApoE Neprilysin/insulin-degrading enzyme 
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis被引量：17
《Science China(Life Sciences)》2011年第8期744-751,共8页Charlene SUPNET Ilya BEZPROZVANNY 
supported by the McKnight Neuroscience of Brain Disorders Award and NIH grant R01AG030746
Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive ...
关键词：calcium signaling NEURODEGENERATION PRESENILINS Alzheimer＇s disease GAMMA-SECRETASE AMYLOID 
Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice
《Neuroscience Bulletin》2009年第3期131-137,共7页张冬丽 陈逸群 姜旭 嵇婷婷 梅兵 
supported by the grants from Shanghai Science and Technology Commission (06DZ19003);National Natural Science Foundation of China (30870790);supported in part by 973 Project (2009CB918402)
Objective This report aims to describe the oxidative damage profile in brain ofpresenilinl andpresenilin2 conditional double knockout mice （dKO） at both early and late age stages, and to discuss the correlation betw...
关键词：PRESENILINS Alzheimer＇s disease oxidative damage 8-OHDG 
Effects of presenilins and β-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons被引量：2
《Acta Pharmacologica Sinica》2004年第2期181-185,共5页WeiZHANG Hong-weiJIN Xiao-liangWANG 
Project supported by the State Key Technologies R & D Programme (973), No 1998051106.
AIM: To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed rectifier potassium channels (IK) in the cultured rat hippocampal neurons. METHODS: PS-1, ...
关键词：PRESENILIN-1 presenilin-2 amyloid beta-protein precursor potassium channels TRANSFECTION patch-  clamp techniques 
早老蛋白(Presenilins)功能研究进展被引量：3
《生命科学》2000年第5期217-220,共4页鲍云鹤 邹泉 郑坚瑜 
国家863青年基金
编码早老蛋白（Ｐｒｅｓｅｎｉｌｉｎｓ，ＰＳｓ）的基因ｐｓ－１、ｐｓ－２被认为是构成早发家族性老年痴呆（ｅａｒｌｙ－ｏｎｓｅｔ ｆａｍｉｌｉａｌ Ａｌｚｈｅｉｍｅｒ’ｓ ｄｉｓｅａｓｅ，ＦＡＤ）的主要致病基因。早老蛋白具...
关键词：早老蛋白 APP Notch信号路径 细胞凋亡 家族性AD 
老年性痴呆相关基因Presenilins研究进展被引量：1
《国外医学（临床生物化学与检验学分册）》2000年第1期1-3,共3页李梅 董为人 陈鸣凤 
新发现的与老年性痴呆（Ａｌｚｈｅｉｍｅｒ’ｓ ｄｉｓｅａｓｅ，ＡＤ）相关的两个基因 Ｐｒｅｓｅｎｉｌｉｎ和Ｐｒｅｓｅｎｉｌｉｎ２是目前国外分子生物学及老年医学的一个研究热点，本文就这两个基因的分子结构、基因突变、可能的...
关键词：老年性痴呆 相关基因 PRESENILINS 研究进展 
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