GAMMA-SECRETASE

作品数：5被引量：17H指数：1
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相关领域：医药卫生生物学更多>>
相关作者：崔进裴刚更多>>
相关机构：同济大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金更多>>
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A novel generation of potent gamma-secretase modulators: Combat Alzheimer's disease and Down syndrome–associated Alzheimer's disease
《Neural Regeneration Research》2026年第1期316-317,共2页Xu-Qiao Chen 
Alzheimer's disease and Down syndrome:Down syndrome(DS)is a genetic disorder caused by the presence of an extra complete or partial chromosome 21.Over the past few decades,significant advancements in medical treatment...
关键词：ALZHEIMER DOWN NURSING 
Neurotrophin receptors,gamma-secretase inhibitors,and neurodegeneration of basal forebrain cholinergic neurons
《Neural Regeneration Research》2022年第7期1493-1494,共2页Marçal Vilar 
supported by the Spanish Minister of Economy and Competitiveness grant SAF2017-84096-R;by the Generalitat Valenciana 2018-55,to MV。
The amyloid hypothesis of Alzhemer’s disease(AD)postulates that the generation of amyloid-beta(Aβ)peptide from the amyloid precursor protein(APP)by the action of theγ-secretase complex is one of the principal cause...
关键词：AMYLOID AΒ CHOLINERGIC 
Defining the minimum substrate and charge recognition model of gamma-secretase
《Acta Pharmacologica Sinica》2017年第10期1412-1424,共13页Yan YAN Ting-Hai XU Karsten MELCHER H Eric XU 
γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can oligomerize and aggregate to form amyloid plaque...
关键词：Alzheimer＇s disease amyloid beta （Aβ） amyloid precursor protein （APP） C99  γ-secretase minimum substrate Notchprotein recognition model 
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis被引量：17
《Science China(Life Sciences)》2011年第8期744-751,共8页Charlene SUPNET Ilya BEZPROZVANNY 
supported by the McKnight Neuroscience of Brain Disorders Award and NIH grant R01AG030746
Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive ...
关键词：calcium signaling NEURODEGENERATION PRESENILINS Alzheimer＇s disease GAMMA-SECRETASE AMYLOID 
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats
《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li 
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...
关键词：chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer＇s disease brain injury neural regeneration 
廖笳因(Chia-Yin Liao) 廖永豐(Yung-Feng Liao) 王柏堅(Bo-Jeng Wang) 黃詩雅(Shy-Ya Huang) 胡明寬(Ming-Kuan Hu) 
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