国家自然科学基金(30670231)

作品数:5被引量:1H指数:1
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相关作者:顾美儿吴宝金刘桂杰尹洪萍亢晓冬更多>>
相关机构:杭州师范大学扬州大学更多>>
相关期刊:《Science Bulletin》《Zoological Research》《科学通报》《Current Zoology》更多>>
相关主题:KITKIT基因小鼠突变小鼠纯合子更多>>
相关领域:生物学一般工业技术电气工程农业科学更多>>
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Mapping of genetic modifiers of Plcd1 in scant hair mice(snthr^(1Bao))
《Chinese Science Bulletin》2010年第35期4026-4031,共6页WU BaoJin ZENG YongMei MAO HuiHua YIN LiJing ZHU Jie YANG WeiWei YIN XiaoShu WU PeiLin ZHANG WeiDong 
supported by the National Natural Science Foundation of China (30670231 and 30400266);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China
The scant hair mutant mouse(locus symbol:snthr1Bao) is a recessive mutation that originated in an ethylnitrosourea chemical carcinogenesis study using the DBA/2J inbred strain.The gene responsible for the mutation was...
关键词:突变小鼠 遗传修饰 映射 QTL检测 基因符号 信号转导通路 基因分型 未成年人 
Abnormal gonad development in Kit^(W-2Bao) mice caused by a Kit gene missense mutation被引量:1
《Chinese Science Bulletin》2010年第36期4143-4149,共7页WU BaoJin YIN LiJing LU ZhengLan YIN YuShu YANG WeiWei YANG Rong KANG XiaoDong LIU GuiJie YIN HongPing YU LiPing Gu MeiEr WU PeiLin 
supported by the National Natural Science Foundation of China (30670231);the Zhejiang Science and Technology Project for Laboratory Animal (2009F80022)
KitW-2Bao mice are single-gene autosomal dominant mutation mice with a B6 background that were bred in our laboratory. Heterozygotes had morphological characteristics including albinism of the abdomen, extremities, an...
关键词:突变小鼠 结构异常 单基因 套件 性腺 原始生殖细胞 工具包 杂合子缺乏 
Kit基因错义突变导致Kit^(W-2Bao)小鼠生殖腺的异常发育
《科学通报》2010年第31期3032-3039,共8页吴宝金 殷黎静 卢增兰 殷筱舒 杨伟伟 杨蓉 亢晓冬 刘桂杰 尹洪萍 俞利平 顾美儿 吴培林 
国家自然科学基金(30670231);浙江省实验动物科技计划(2009F80022)资助项目
KitW-2Bao是本实验室培育的B6背景、呈单基因显性遗传的突变系小鼠,杂合子腹部、肢端及尾端白化,纯合子全身白化、黑眼、不育.突变纯合子小鼠生殖腺变小、结构异常、缺乏生殖细胞,杂合子雄鼠部分精曲小管内无生精细胞.通过连锁分析将突...
关键词:小鼠 KIT 错义突变 生殖腺 
Homozygous lethality and heterozygous spotting due to a novel missense mutation in the mouse Kit gene
《Current Zoology》2009年第6期430-434,共5页Baojin WU Lijing YIN Xiaoshu YIN Weiwei YANG Bing CHEN Zhengfeng XUE Peilin WU 
supported by the National Natural Science Foundation of China(NO.30670231);Public Service Project of Lab Animal Science(NO.2008F80005);SRF for ROCS,SEM
N-ethyl-N-nitrosourea (ENU) mutagenesis in mice can be used to study gene function in vivo and to establish genetic mouse models of human disease. In this study, a white spotted mouse (named Kit^W-1 Bao) was obtai...
关键词:White spotting DEATH Mapping Identification KIT 
Kit无义突变致W^(-3Bao)小鼠生殖腺异常及纯合子贫血死亡被引量:1
《Zoological Research》2009年第1期45-52,共8页吴培林 尹洪萍 殷黎静 朱洁 曾咏梅 刘桂杰 亢晓冬 俞利平 顾美儿 袁红 吴宝金 
国家自然科学基金面上项目(30670231)资助
W-3Bao是本研究组通过诱变获得、Kit无义突变的白斑小鼠。突变基因杂合子小鼠腹部、四肢肢端及尾尖白化,其部分精曲小管内无精原细胞。突变纯合子小鼠在胚胎后期色泽苍白、个体矮小,于出生前后死亡;血液学检查发现纯合子小鼠血色素极低...
关键词:W-3Bao小鼠 KIT基因 死亡 大红细胞贫血 生殖腺异常 
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