国家自然科学基金(51375371)

作品数:11被引量:50H指数:3
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相关作者:连芩李涤尘靳忠民张维杰贺健康更多>>
相关机构:西安交通大学西安电子科技大学利兹大学西安交通大学医学院第一附属医院更多>>
相关期刊:《中国修复重建外科杂志》《Journal of Bionic Engineering》《电加工与模具》《机械工程学报》更多>>
相关主题:3D打印ENGINEERINGWOUND_HEALINGBIOPRINTING3-D更多>>
相关领域:自动化与计算机技术医药卫生金属学及工艺生物学更多>>
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Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models被引量:1
《Journal of Bionic Engineering》2023年第1期105-118,共14页Tian Jiao Qin Lian Weilong Lian Yonghui Wang Dichen Li Rui L.Reis Joaquim Miguel Oliveira 
funded by the National Key R&D Program of China(2018YFE0207900);People's Liberation Army(BWS17J036,18-163-13-ZT-003-011-01);the National Natural Science Foundation of China(51835010 and 51375371);Xi’an Science and Technology Plan Project(21ZCZZHXJS-QCY6-0012);Shaanxi Science and Technology Project(2022KXJ-147)。
3D printing technology has great potential for the reconstruction of human skin.However,the reconstructed skin has some differences from natural skin,largely because the hydrogel used does not have the appropriate bio...
关键词:Bioink Bioprinting-Collagen sodium alginate hydrogel-Skin Wound healing BIONIC 
3D Bioprinted Skin Substitutes for Accelerated Wound Healing and Reduced Scar被引量:1
《Journal of Bionic Engineering》2021年第4期900-914,共15页Qin Lian Tian Jiao Tingze Zhao Huichao Wang Siming Yang Dichen Li 
This work was supported by the National Key R&D Program of China(No.2018YFE0207900);the Development projects of Key research of People’s Liberation Army(No.BWS17J036,18-163-13-ZT-003-011-01);the National Natural Science Foundation of China(51835010 and 51375371)。
The shortage of skin for grafting continues to be a major problem in the treatment of serious skin injuries.3D bioprinting provides a new way to solve this problem.However,current 3D printed skin is less effective in ...
关键词:3D bioprinting bionic design skin substitutes wound healing reducing scar 
皮肤修复生物3D打印的研究进展与挑战被引量:6
《光电工程》2021年第8期1-18,共18页连伟龙 连芩 焦天 何晓宁 赵明 胡大海 万敏 
工信部增材制造专项(2018YFE0207900);中国人民解放军科技计划(BWS17J036);季华实验室建设项目(X200031TM200);国家自然科学基金项目(51835010,51375371)。
皮肤作为人体最大的器官,有着屏障功能、免疫应答、防止水分流失和排泄废物等重要作用。大面积的严重皮肤损伤患者会由于缺乏充足的可移植皮肤而死亡。生物3D打印技术的发展为可移植皮肤的制造提供了解决办法。生物3D打印技术可以定制...
关键词:生物3D打印 皮肤 生物墨水 细胞 光电技术 
Preparation,Mechanical and Biological Properties of Inkjet Printed Alginate/Gelatin Hydrogel被引量:2
《Journal of Bionic Engineering》2021年第3期574-583,共10页Tian Jiao Qin Lian Tingze Zhao Huichao Wang Dichen Li 
This work was supported by the Development Projects of Key Research(No.2018YFE0207900);People’s Liberation Army(No.BWS17J036,18-163-13-ZT-003-011-01);the National Natural Science Foundation of China(Nos.51835010 and 51375371).
3D printing has made remarkable progress in soft tissue reconstruction enabling the custom design of complex material implants with patient specific geometry.The aim of this study was to inkjet print mechanically rein...
关键词:BIOFABRICATION inkjet printing double crosslinking ink mechanical and biological properties hydrogel preparation 
Direct-writing Process and in vivo Evaluation of Prevascularized Composite Constructs for Muscle Tissue Engineering Application被引量:1
《Journal of Bionic Engineering》2020年第3期457-468,共12页Qin Lian Tingze Zhao Tian Jiao Yige Huyan Heng Gu Lin Gao 
This work was supported by grants from the Science and technology Projects(BWS17J036,18-163-13-ZT-003-011-01);the National Natural Science Foundation of China(51835010 and 51375371);We thank Mr.Linian Zhou for his work of bioprinting experiments.
Tissue engineered skeletal muscle is expected to treat muscle defects caused by trauma and disease.However,designing and manufacturing thick and complex tissue engineered skeletal muscle requires vascularization to en...
关键词:DW muscle tissue engineering in vivo experiment prevascularization 
GelMA复合凝胶的挤出式3D打印工艺及其性能研究被引量:5
《机械工程学报》2020年第1期196-204,共9页顾恒 连芩 王慧超 李涤尘 靳国瑞 崔滨 
科学技术(BWS17J036,18-163-13-ZT-003-011-01);国家自然科学基金(51835010,51375371)资助项目
甲基丙烯酸酐明胶(Methacrylated gelatin,Gel MA)是具有光敏官能团的改性明胶,有良好的生物相容性,广泛用于构建皮肤、神经等软组织支架。然而,光照交联单一成分的GelMA,其力学性能和结构维持性较差,难以通过挤出3D打印成形生物支架。...
关键词:甲基丙烯酸酐化明胶 复合凝胶 挤出式生物3D打印 人真皮成纤维细胞 
Preparation and Endothelialization of Multi-level Vessel-like Network in Enzymated Gelatin Scaffolds被引量:2
《Journal of Bionic Engineering》2018年第4期673-681,共9页Guirong Dong Qin Lian Laixia Yang Wei Mao Shiyang Liu Chao Xu 
This work was supported by National Natural Science Foundation of China (Grant No. 51375371) and the High-Tech Projects of China (Grant Nos. 2015AA020303 and 2015AA042503).
Loss of function of large tissues is an urgent clinical problem. Although the artificial microfluidic network fabricated in large tis- sue-engineered constructs has great promise, it is still difficult to develop an e...
关键词:large-size scaffolds vascular network enzymaticaUy gelatin hydrogel ENDOTHELIALIZATION muscle tissue engineering 
多材料面曝光增材制造方法与加工工艺研究被引量:3
《电加工与模具》2018年第1期47-50,60,共5页武向权 连芩 何晓宁 孟佳丽 李涤尘 靳忠民 
国家自然科学基金资助项目(51323007,51375371);陕西省科技项目(2016KTZDGY07-01);广东省科技项目(2016B090915002)
零件的多材料组成可改变其机械性能,并增加其他附属功能。通过搭建一种分区旋转槽多材料面曝光增材制造系统,验证了多材料光固化成形工艺,完成了含有两种树脂材料的复杂结构零件的加工。分析了零件的加工质量和加工精度,并进行了多材料...
关键词:多材料 面曝光 增材制造 旋转槽 
喷墨打印光固化水凝胶工艺研究
《电加工与模具》2015年第5期38-42,51,共6页李志朝 连芩 贾书海 吕毅 李涤尘 
国家高技术研究发展计划(863计划)资助项目(2015AA020303);国家自然科学基金资助项目(51375371)
针对可光固化水凝胶成形速度快、粘度低的特点,提出了一种包括电磁阀喷头系统和光源系统的喷墨式打印方法,能克服以成缸溶液直接扫描加工多种可光固化水凝胶存在的加工复杂、材料易被污染和损耗高等缺点。用光学显微镜对固化液滴和堆积...
关键词:光固化水凝胶 喷墨 模型 三维方块 
Patient-Specific Design and Biomechanical Evaluation of a Novel Bipolar Femoral Hemi-Knee Prosthesis被引量:3
《Journal of Bionic Engineering》2014年第2期259-267,共9页Qin Lian Dichen Li Zhongmin Jin ZhenWang Yuhan Sun 
Acknowledgments This work was supported by grants from the Natural Science Foundation of China (51075320, 51375371, 51323007), and the Fundamental Research Funds for the Central Universities. The authors would like to acknowledge the contributions of Peng Liu of Fourth Military Medical University.
While total knee replacement is successful, hemiarthroplasty is necessary for some young, obese and active patients who are especially not suitable for unicompartmental or total knee prostheses. Hemiarthroplasty also ...
关键词:hemi knee prosthesis custom-design bipolar mechanism finite element analysis biomechanics 
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