国家重点基础研究发展计划(2013ZX09103001-015)

作品数：3被引量：7H指数：2
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相关作者：马天阳祁金龙王克威张海林更多>>
相关机构：北京大学河北医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关主题：KCNQRETIGABINEOPENERANTI-NOCICEPTIVERODENTS更多>>
相关领域：医药卫生生物学更多>>
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Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices被引量：3
《Acta Pharmacologica Sinica》2017年第9期1248-1256,共9页Hui PENG Xi-ling BIAN Fu-cui MA Ke-Wei WANG 
The prefrontal cortex （PFC） critical for higher cognition is implicated in neuropsychiatric diseases, such as Alzheimer＇s disease, depression and schizophrenia. The voltage-activated Kv7/KCNQ/M-channel or M-current...
关键词：Kv7 KCNQ M-CURRENT prefrontal cortex pyramidal neurons EXCITABILITY MEPSC RETIGABINE XE991 neuropsychiatric diseases 
Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-1ysine and its anti-nociceptive effects on inflammatory pain in rodents被引量：4
《Acta Pharmacologica Sinica》2016年第8期1054-1062,共9页Bo-chuan TENG Yan SONG Fan ZHANG Tian-yang MA Jin-Iong QI Hai-lin ZHANG Gang LI KeWei WANG 
Aim： The aim of this study was to examine the activation of neuronal Kv7/KCNQ channels by a novel modified Kv7 opener QO58-1ysine and to test the anti-nociceptive effects of QO58-1ysine on inflammatory pain in rodent...
关键词：QO58-1ysine Kv7/KCNQ M-channel pharmacokinetics XE991 RETIGABINE inflammatory pain 
Development of high-performance liquid chromatography assay for pharmacokinetic analysis of KCNQ/M-channel opener QO58-lysin in rat plasma
《Journal of Chinese Pharmaceutical Sciences》2014年第3期153-158,共6页马天阳 滕博川 祁金龙 张海林 王克威 
Ministry of Science and Technology of China(Grant No.2013ZX09103001-015 and 2013CB531300);the National Science Foundation of China(Grant No.81221002)
A simple, reliable and efficient assay for quantitative analysis of a novel Kv7/KCNQ/M-channel opener QO58-lysin in rat plasma was developed using high-performance liquid chromatography（HPLC） with UV detection. Sepa...
关键词：KCNQ opener QO58-lysin HPLC PHARMACOKINETICS 
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