国家自然科学基金(81273251)

作品数:7被引量:53H指数:5
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相关作者:郑永唐刘建昆夏雪山张高红更多>>
相关机构:中国科学院成都军区昆明总医院河北医科大学昆明学院更多>>
相关期刊:《免疫学杂志》《西北药学杂志》《Zoological Research》《中国药学杂志》更多>>
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益母草中的二萜类化合物研究被引量:9
《西北药学杂志》2018年第4期427-432,共6页秦静 陈子豪 刘建昆 熊媛 贾静 王刘燕 句红萍 张高红 
国家自然科学基金项目(编号:81273251);云南省科技厅项目(编号:2016FD110);云南省教育厅项目(编号:2016ZZD178);昆明学院校级课题(编号:YJL16001)
目的对益母草地上部分体积分数为75%的丙酮提取物的乙酸乙酯萃取部位的化学成分进行研究。方法采用硅胶、Sephadex LH-20凝胶和反相C18色谱柱,对益母草乙酸乙酯提取物进行分离纯化,通过波谱数据鉴定所得化合物的结构。结果从中分离得到1...
关键词:益母草 二萜化合物 分离纯化 结构鉴定 
抗登革病毒化学药物研究进展被引量:5
《中国药学杂志》2017年第10期809-813,共5页张高红 郑永唐 
国家自然科学基金资助项目(81273251,81172876)
登革热是由埃及伊蚊和白纹伊蚊传播的一种重要虫媒病毒引起的疾病。登革病毒感染能够引起登革热、登革出血热和登革休克综合征等多种症状。迄今为止尚无抗登革病毒药物上市。研发中的药物按照作用机制可分为抗登革病毒的复制周期抑制剂...
关键词:登革热 登革热病毒 登革出血热 登革休克综合征 抗登革病毒药物 
艾滋病猕猴模型的肠道病理学研究进展被引量:8
《免疫学杂志》2015年第3期265-269,276,共6页张琳萄 夏雪山 郑永唐 
国家自然科学基金(81172876,81273251,81471620,U1202228);国家重大科学研究计划课题(2012CBA01305);国家科技重大专项课题(2012ZX10001-007,2013ZX10001-002)
HIV是导致AIDS的病原体,HIV感染后会引起机体免疫缺陷并导致多个器官的损伤,其中肠道损伤是HIV感染后最常见的病变之一。肠道损伤既是HIV致病的直接诱因,也能间接地影响机体多项免疫功能进而加速疾病进展。非人灵长类动物在组织结构、...
关键词:AIDS SIV 灵长类动物 胃肠道 病理学变化 
Experimental primates and non-human primate(NHP) models of human diseases in China: current status and progress被引量:19
《Zoological Research》2014年第6期447-464,共18页Xiao-Liang ZHANG Wei PANG Xin-Tian HU Jia-Li LI Yong-Gang YAO Yong-Tang ZHENG 
supported by the National Natural Science Foundation of China(81172876,81273251,U1202228,81471620);the National Special Science Research Program of China(2012CBA01305);the National Science and Technology Major Project(2013ZX10001-002,2012ZX10001-007);the Knowledge Innovation Program of CAS(KSCX2-EW-R-13,KJZD-EW-L10-02)
Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biom...
关键词:Non-human primates Experimental primates Animal models Current status 
Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques (Macaca leonina)被引量:4
《Zoological Research》2014年第6期465-473,共9页Hong-Yi ZHENG Ming-Xu ZHANG Lin-Tao ZHANG Xiao-Liang ZHANG Wei PANG Long-Bao LYU Yong-Tang ZHENG 
This work was supported by the National Special Science Research Program of China (2012CBA01305); the National Natural Science Foundation of China (81172876, U0832601, 81273251, U1202228); the Knowledge Innovation Program of CAS (KSCX2-EW-R-13) and the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007)We thank Mr. Zhen-Fei Hu,Gui Li and Dong-Ti Huang of Kunming Primate Research Center for their assistance with the experiments.
Pig-tailed macaques(Macaca nemistrina group) have been extensively used as non-human primate animal models for various human diseases in recent years, notably for AIDS research due to their sensitivity to HIV-1. North...
关键词:Northern pig-tailed macaque Flow cytometry Leukocyte subpopulation Age Sex 
Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina)被引量:5
《Zoological Research》2014年第3期186-195,共10页Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG 
Foundation items: This work was supported by the National Basic Research Program (2012CBA01305); the National Natural Science Foundation of China (81172876, U0832601, 81273251 and U 1202228) the Knowledge Innovation Program of CAS (KSCX2-EW-R-13, Y206A- 71181), and the Key Scientific and Technological Program of China (2012ZX10001-007, 2013ZX10001-002). Acknowledgements: We thank Prof. Guang-Xia GAO (Institute of Biophysics, Chinese Academy of Sciences) for kindly providing HSIV proviral plasmids.We also thank Long-Bao LV, Gui LI and Dong- Ti HUANG of Kunming Primate Research Center for their assistance in obtaining blood samples from northem pig-tailed macaques (M. leonina) and Chinese rhesus macaques.
The northern pig-tailed macaque (Macaca leonina) has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus...
关键词:HIV-1 HSIV REPLICATION PBMC Northern pig-tailed macaque (Macaca leonina) 
Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina)被引量:8
《Zoological Research》2014年第3期196-203,共8页Xiao-Liang ZHANG Wei PANG De-Yao DENG Long-Bao LV Yue FENG Yong-Tang ZHENG 
Foundation items: This work was supported by the National Natural Science Foundation of China (81172876, U0832601, 81273251, U1202228); the National Special Science Research Program of China (2012CBA01305); the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007) and the Knowledge Innovation Program of CAS (KSCX2-EW-R-13).
The northem pig-tailed macaque (NPM, Macaca leonina) has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3...
关键词:Northern pig-tailed macaque (Macaca leonina) IMMUNOGLOBULIN Complement C-reactive protein 
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