国家自然科学基金(30672564)

作品数:3被引量:19H指数:2
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相关作者:楼宜嘉史强更多>>
相关机构:浙江大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《中国药理学与毒理学杂志》更多>>
相关主题:MURINECHOCARDIOMYOCYTESPPARΑPGC-1Α更多>>
相关领域:医药卫生生物学更多>>
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Icariin promotes expression of PGC-1α,PPARα,and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro被引量:15
《Acta Pharmacologica Sinica》2007年第10期1541-1549,共9页Ling DING Xing-guang LIANG Dan-yan ZHU Yi-jia LOU 
This project was supported by the National Natural Sciences Foundation of China(№ 30171121,30472112,and 30672564);the Key Grant of the Chinese Ministry of Education(№ 03088);the International Joint Key Grant of Zhejiang Province(№ 2003C24005)
Aim: To investigate the effect of icariin on the expression of peroxisome proliferatoractivated receptor y coactivator- 1 alpha (PGC- 1 α), peroxisome proliferator- activated receptor alpha (PPARα), and nuclear...
关键词:ICARIIN PGC-1Α PPARΑ NRF-1 mitochon-drial CARDIOMYOCYTES embryonic stem cells differentiation 
Time-dependence of cardiomyocyte differentiation disturbed by peroxi-some proliferator-activated receptor a inhibitor GW6471 in murine embryonic stem cells in vitro被引量:2
《Acta Pharmacologica Sinica》2007年第5期634-642,共9页Ling DING Xing-guang LIANG Yiojia LOU 
the National Natural Sciences Foundation of China(№ 30171121,30472112,30672564);the Key Grant of the Chinese Ministry of Education(№ 03088);the International Joint Key Grant of Zhejiang Province(№ 2003C24005)
Aim: To investigate the possible roles of peroxisome proliferator-activated receptorα (PPARα) and the signal pathway regulating the transcription of PPARα in the cardiomyocyte differentiation course of murine em...
关键词:peroxisome proliferator-activated receptor α p38 MAPK embryonic stem cells cardio-myocytes differentiation 
活性氮对肝脏微粒体谷胱甘肽转移酶1修饰激活的研究进展被引量:2
《中国药理学与毒理学杂志》2007年第4期297-300,共4页史强 楼宜嘉 
国家自然科学基金资助课题(30070904);国家自然科学基金资助课题(30472112);国家自然科学基金资助课题(30672564)~~
活性氮导致肝脏微粒体谷胱甘肽转移酶1(MGST1)修饰激活是近年来研究热点之一,由于其半胱氨酸(Cys49)可感受亲电子剂等而被修饰,担任"感受器"角色,行使对机体的保护作用。以过氧亚硝酸盐和S-亚硝基谷胱甘肽为代表的活性氮,可引起MGST1的...
关键词:微粒体  谷胱甘肽转移酶 过氧亚硝酸盐 S-亚硝基谷胱甘肽 
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