国家自然科学基金(30830056)

作品数：4被引量：26H指数：3
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相关作者：郭志坚侯凡凡更多>>
相关机构：南方医科大学更多>>
相关期刊：《Science China(Life Sciences)》《中华内科杂志》《Chinese Medical Journal》更多>>
相关主题：PODOCINOXIDASENEPHRINNADPHPODOCYTES更多>>
相关领域：医药卫生生物学更多>>
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Role of reactive oxygen species in the renal fibrosis被引量：7
《Chinese Medical Journal》2012年第14期2598-2601,共4页NIE Jing HOU Fan-fan 
This study was supported by a grant from the National Natural Science Foundation of China （No. 30830056 and No. U0932002）. Conflict of interests： None.
Renal fibrosis is a common pathway of progressive renal diseases leading to end-stage renal disease regardless of the etiology. Accumulating evidence indicates that oxidative stress, resulting in generation of reactiv...
关键词：reactive oxygen species nicotinamide adenine dinucleotide phosphate oxidase renal fibrosis advanced oxidation protein products 
Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK被引量：14
《Science China(Life Sciences)》2010年第1期68-77,共10页YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. 
supported by the National Natural Science Foundation of China (Grant Nos 30830056 and 30830056);the National Basic Research Program of China (Grant No 2006CB503904) to Dr HOU FanFan;the National Natural Science Foundation of China (Grant No 30971382);the Natural Science Foundation of Guangdong Province (Grant No 06024402) to Dr LIANG Min
Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats ...
关键词：advanced oxidation protein products PODOCYTE NEPHRIN PODOCIN NADPH OXIDASE 
蛋白质糖化氧化修饰产物参与慢性肾脏病进展被引量：3
《中华内科杂志》2009年第6期510-512,共3页郭志坚 侯凡凡 
国家自然科学基金（30830056,30600289）;国家“973”项目（2006CB503904）
慢性。肾脏病（CKD）是一组进行性的慢性疾病群,其最终后果是发展至终末期。肾病（ESRD）。ESRD患者虽能依赖肾替代治疗（透析或肾移植）生存,但耗费大量医疗资源。据统计,在美国CKD患者占医疗人群的6％,但其治疗费用却占医疗总预算的2...
关键词：慢性肾脏病 修饰产物 糖化氧化 蛋白质 尿毒症患者 ESRD患者 医疗资源 肾替代治疗 
Coronary stenting does not improve the long-term cardiovascular outcome of patients with mild to moderate renal insufficiency被引量：2
《Chinese Medical Journal》2009年第2期158-164,共7页XIE Di HOU Yu-qing HOU Fan-fan ZHANG Wei-ru LI Yong GUO Zhi-gang GUO Zhi-jian ZHANG Xun 
This study was supported by the grants from the National Natural Science Foundation of China （No. 30830056） and the National 973 Program （No. 2006CD 503904）.
Background Several studies have shown that coronary stenting reduces the frequency of clinical and angiographic restenosis in patients with mild to moderate renal insufficiency. However, less is known about the long-t...
关键词：long-term outcomes REVASCULARIZATION renal insufficiency STENTS 
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