Supported by National Key Basic Research and Development Program of China (Grant No. 2003CB114205);National High Technology Research and Development Program of China (Grant No. 2006AA02Z185);the National Natural Science Foundation of China (Grant No. 30570019);the Shanghai Municipal Council of Science and Technology, and Shanghai Leading Academic Discipline Project B203
Cultivation shift from 30℃ to 37℃ significantly enhanced validamycin (VAL) production. Analyzed by reverse-transcription PCR, the transcription of three val genes, valA, valK and valG, representing the three operons...
Supported by National Basic Research Project (Grant No. 2003CB114205);Key Technologies R&D Programme (Grant No. 2004BA713B02-03)
Among eight components of avermectin, B1 fractions have the most effective antiparasitic activities and the lowest level of toxic side-effects and are used widely in veterinary and agricultural fields. In-traspecific ...
Supported by the National Basic Research Program of China (Grant No. 2003CB114205)
In Streptomyces griseus, AdpA, the key transcriptional activator in the A-factor regulatory cascade, switches on the transcription of multiple genes required for secondary metabolism and morphological differentiation....