国家自然科学基金(81322053)

作品数：6被引量：55H指数：6
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相关作者：季莉莉牛成伟王峥涛蒋萍庞纯更多>>
相关机构：上海中医药大学江苏食品药品职业技术学院更多>>
相关期刊：《药学学报》《中国药理学通报》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Acta Pharmacologica Sinica》更多>>
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Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway被引量：13
《Acta Pharmacologica Sinica》2019年第1期75-85,共11页Yao Jin Zhen-lin Huang Li Li Yang Yang Chang-hong Wang Zheng-tao Wang Li-li Ji 
the State Major Science and Technology Special Projects during the 12th Five-year Plan (2015ZX09501004-002-002);the National Natural Science Foundation of China (81322053,81573679).
Toosendanin (TSN)is the main active compound in Toosendan Fructus and Meliae Cortex,two commonly used traditional Chinese medicines.TSN has been reported to induce hepatotoxicity,but its mechanism remains unclear.In t...
关键词：QUERCETIN TOOSENDANIN HEPATOTOXICITY NRF2 GSH GCL traditional chinese medicine 
半枝莲对黄药子肝毒性的保护作用及其机制被引量：13
《药学学报》2016年第3期373-379,共7页牛成伟 季莉莉 王峥涛 
国家重大新药创制专项课题资助项目(2015ZX09501004-002-002);国家自然基金优秀青年基金资助项目(81322053)
本文观察半枝莲醇提物(ethanol extract of Herba Scutellariae Barbatae,SE)对黄药子诱导肝毒性的保护作用及其机制。小鼠灌胃给予不同剂量SE的同时给予黄药子乙酸乙酯部位(ethyl acetate fraction of Rhizoma Dioscoreao Bulbiferae L...
关键词：黄药子 半枝莲 肝毒性 炎性损伤 
Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals被引量：7
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2015年第7期602-610,共9页Chun PANG Yu-chen SHENG Ping JIANG Hai WEI Li-li JI 
Project supported by the National Natural Science Foundation of China(No.81322053);the Program for New Century Excellent Talents in University(No.NCET-11-1054);the"Shu Guang"Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation(No.13SG43);the State Major Science and Technology Special Projects during the 12th Five-Year Plan(No.2012ZX09505001-002),China
Chlorogenic acid（CGA）, a polyphenolic compound, is abundant in fruits, dietary vegetables, and some medicinal herbs. This study investigated the prevention of CGA against acetaminophen（AP）-induced hepatotoxicity a...
关键词：Chlorogenic acid ACETAMINOPHEN CYP450 Oxidative stress injury 
Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism被引量：9
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第12期1039-1047,共9页Jia-qi ZHANG Liang SHI Xi-ning XU Si-chong HUANG Bin LU Li-li JI Zheng-tao WANG 
Project supported by the "Shu Guang" Project from Shanghai Municipal Education Commission and Shanghai Education Development Foundation(No.13SG43);the National Natural Science Foundation of China(No.81322053);the Program for New Century Excellent Talents in University(No.NCET-11-1054),China
This study observes the therapeutic detoxification of quercetin, a well-known flavonoid, against carbon tetrachlodde （CCI4） induced acute liver injury in vivo and explores its mechanism. QuerceUn decreased CCI4-incr...
关键词：HEPATOTOXICITY Oxidative stress Peroxiredoxin （Prx） Nuclear factor erythroid 2-related factor 2 （Nrf2） TrxR Trx HO-1 
Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo被引量：8
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第6期540-547,共8页Jun-ming WANG Yu-chen SHENG Li-li JI Zheng-tao WANG 
Project supported by the Program for New Century Excellent Talents in University(No.NCET-11-1054);the National Natural Science Foundation of China(No.81322053);the Program for Changjiang Scholars and Innovative Research Team in University(No.PCSIRTIRT1071),China
The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B...
关键词：Ferulic acid Diosbulbin B HEPATOTOXICITY Oxidative stress injury Anti-tumor activity 
黄芩素激活核转录因子Nrf2拮抗肝毒性的研究被引量：9
《中国药理学通报》2014年第4期546-549,共4页庞纯 蒋萍 季莉莉 
国家自然科学基金优秀青年基金资助项目(No 81322053);教育部新世纪优秀人才计划(No NCET-11-1054)
目的研究黄芩素(Baicalein,BAI)对核转录因子Nuclear factor erythroid 2-related factor 2(Nrf2)的转录激活,以及对四氯化碳(carbon tetrachloride,CCl4)、乙醇(ethanol)和对乙酰氨基酚(acetaminophen,APAP)诱导的人正常肝L-02细胞毒...
关键词：黄芩素 人正常肝L-02细胞 NRF2 肝毒性 报告基因 L-02 NRF2 
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