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国家自然科学基金(30470525): 作品数：16被引量：72H指数：6; 导出分析报告; 相关作者：胡国清唐曦肖旭轩燕海姣汪锐更多>>; 相关机构：华中科技大学华中科技大学同济医学院同济医院武汉市第一医院华中科技大学同济医学院附属同济医院更多>>; 相关期刊：《Acta Pharmacologica Sinica》《山东医药》《Chinese Medical Journal》《华中科技大学学报（医学版）》更多>>; 相关主题：鼻咽肿瘤鼻咽癌NASOPHARYNGEAL_CARCINOMAMAGNETIC_RESONANCE_IMAGINGMRI更多>>; 相关领域：医药卫生生物学理学更多>>

Specific targeting of angiogenesis in lung cancer with RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a 4.7T magnetic resonance scanner被引量：6: 《Chinese Medical Journal》2013年第12期2242-2247,共6页LIU Can LIU Dong-bo LONG Guo-xian WANG Jun-feng MEI Qi HU Guang-yuan QIU Hong HU Guo-qing; Background Angiogenesis is an essential step for tumor development and metastasis.The cell adhesion molecule αvβ3 integrin plays an important role in angiogenesis and is a specific marker of tumor angiogenesis.A nov...; 关键词：ultrasmall superparamagnetic iron oxide particles ARG-GLY-ASP avfβ magnetic resonance imaging

Epidermal growth factor receptor-targeted ultra-small superparamagnetic iron oxide particles for magnetic resonance molecular imaging of lung cancer cells in vitro被引量：7: 《Chinese Medical Journal》2012年第13期2322-2328,共7页CHEN Chun-li HU Guang-yuan MEI Qi QIU Hong LONG Guo-xian HU Guo-qing; This study was supported by a grant from the National Natural Science Foundation of China （No. 30470525）.; Background Magnetic resonance （MR） molecular imaging can detect abnormalities associated with disease at the level of cell and molecule. The epidermal growth factor receptor （EGFR） plays an important role in the d...; 关键词：ultra-small superparamagnetic iron oxide epidermal growth factor receptor ＂magnetic resonance imaging ＂ target

Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation被引量：16: 《Acta Pharmacologica Sinica》2012年第5期682-690,共9页Dong-bo LIU Guang-yuan HU Guo-xian LONG Hong QIU Qi MEI Guo-qing HU; Acknowledgements We thank Prof Ya CAO at the Cancer Research Institute of Central South University for his gift of the HNE1 and CNE1- LMP1 cell lines. This project was supported by a grant from the National Natural Science Foundation of China （No 30470525）,; Aim： To investigate the mechanisms underlying the anticancer effect of celecoxib on nasopharyngeal carcinoma （NPC）. Methods： NPC cell lines, HNE1 and CNE1-LMP1, were treated with various concentrations of celecoxi...; 关键词：CELECOXIB nasopharyngeal carcinoma APOPTOSIS cell cycle STAT3

Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging被引量：10: 《Acta Biochimica et Biophysica Sinica》2011年第4期301-306,共6页Dongbo Liu Chunli Chen Guangyuan Hu Qi Mei Hong Qiu Guoxian Long Guoqing Hu; This work was supported by a grant from the National Natural Science Foundation of China （30470525）. The authors express sincere appreciation to Prof. Ya Cao, Cancer Research Institute of Central South University, for presenting CNE1 cells.; An accurate definition of clinical target volume （CTV） is essential for the application of radiotherapy in nasopharyngeal carcinoma （NPC） treatment. A novel epidermal growth factor receptor （EGFR）-targeting cont...; 关键词：CETUXIMAB ultrasmall superparamagneticiron oxide epidermal growth factor receptor magneticresonance imaging

A Prospective Study on Therapeutic Gain by Concurrent Chemoradiotherapy for Stage Ⅱ-Ⅳa Nasopharyngeal Carcinoma被引量：3: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第1期58-61,共4页梅齐胡广源龙国贤邱红付强胡国清; supported by a grant from the National Natural Sciences Foundation of China (No. 30470525); The benefit achieved by concurrent chemoradiotherapy（CCR） and sequential chemoradiotherapy（SCR） vs radiotherapy（RT） alone for patients with stage Ⅱ-Ⅳa nasopharyngeal carcinoma（NPC） was compared.A total of 11...; 关键词：nasopharyngeal carcinoma RADIOTHERAPY concurrent chemotherapy sequential chemotherapy long-term survival nasopharyngeal carcinoma RADIOTHERAPY concurrent chemotherapy sequential chemotherapy long-term survival

Inhibitory Effect of Endostar in Combination with Radiotherapy in a Mouse Model of Human CNE2 Nasopharyngeal Carcinoma被引量：5: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第1期62-66,共5页周宁胡广源梅齐邱红龙国贤陈春丽胡国清; supported by a grant from the National Natural Sciences Foundation of China (No. 30470525); The inhibitory effects of Endostar in combination with radiotherapy in BALB/c nude mice model of human CNE2 nasopharyngeal carcinoma and the mechanism were investigated.In nude mice model of CNE2 nasopharyngeal carcin...; 关键词：ENDOSTAR RADIOTHERAPY microvascular density vascular endothelial growth factor

鼻咽癌肿瘤相关分子水平和局部免疫状态与远期生存关系的研究: 《中华放射肿瘤学杂志》2009年第2期158-159,共2页肖旭轩胡国清; 国家自然科学基金项目（30470525）;湖北省科技攻关课题项目（2005AA304B07）;湖北省卫生厅科研基金重点项目（JX3A09）; 现普遍认为EBV编码LMP1蛋白在其致瘤中发挥重要作用。VEGF是目前已知最具活性的促血管生成因子，在肿瘤生长、转移相关事件中具有重要意义。为此笔者对42例经病理证实的初诊鼻咽癌活检标本LMP1、VEGF表达水平、瘤巢中淋巴细胞（LC）浸...; 关键词：分子水平鼻咽癌远期生存免疫状态肿瘤相关 VEGF表达促血管生成因子 LMP1

鼻咽癌组织VEGF表达及淋巴细胞浸润对患者预后的影响: 《临床肿瘤学杂志》2008年第9期774-778,共5页肖旭轩胡国清; 国家自然科学基金项目(30470525);湖北省科技攻关课题(2005AA304B07);湖北省卫生厅科研基金重点项目(JX3A09); 目的:研究鼻咽癌活检组织中血管内皮生长因子(VEGF)的表达及瘤巢中淋巴细胞的浸润程度对鼻咽癌患者远期预后的影响。方法:以免疫组化S-P法检测42例初诊无远处转移鼻咽癌患者活检组织中VEGF的表达情况,在HE切片上观察瘤巢中淋巴细胞的浸...; 关键词：鼻咽癌血管内皮生长因子淋巴细胞浸润生存率预后

鼻咽癌CNE1细胞株裸鼠肌肉和皮下移植瘤模型的建立及比较被引量：2: 《华中科技大学学报（医学版）》2008年第3期358-361,共4页燕海姣胡国清; 国家自然科学基金(No30470525);湖北省科技攻关计划(2005AA304B07)资助项目; 目的建立人类鼻咽癌CNE1细胞系balb/c裸鼠的肌肉移植瘤模型,观察高分化细胞系CNE1在体内的生长及侵袭能力,为下一步研究鼻咽癌亚临床灶奠定基础。方法体外培养LMP1阳性表达的CNE1细胞系,细胞免疫组化法检测LMP1表达情况,将细胞悬液分别...; 关键词：鼻咽肿瘤裸小鼠移植瘤

血管紧张素II受体在肿瘤血管生成中的作用被引量：4: 《肿瘤防治研究》2007年第8期639-642,共4页汪锐龙国贤胡国清; 国家自然科学基金资助项目(30470525); 关键词：血管紧张素Ⅱ受体血管紧张素Ⅱ(AngⅡ) 血管内皮生长因子(VEGF) 肿瘤血管生成(Angiogenesis)

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