《Journal of Pharmaceutical Analysis》

作品数：1840被引量：2269H指数：16
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《Journal of Pharmaceutical Analysis》
主办单位：西安交通大学
最新期次：2024年11期更多>>
发文主题：PHARMACOKINETICSDETERMINATIONLC-MS/MSAPPLICATIONITS更多>>
发文领域：医药卫生理学自动化与计算机技术化学工程更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>
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AI comes to the Nobel Prize and drug discovery
《Journal of Pharmaceutical Analysis》2024年第11期1539-1541,共3页Ying Zhou Yintao Zhang Zhichao Zhang Zhimeng Zhou Feng Zhu 
funded by National Natural Science Foundation of China of China(Grant Nos.:82373790,22220102001,81872798,and U1909208);Natural Science Foundation of Zhejiang Province(Grant No.:RG25H300001,LR21H300001);Fundamental Research Funds for the Central Universities(Grant No.:2018QNA7023);National Key R&D Program of China(Grant No.:2022YFC3400501);Double Top-Class University(Grant No.:181201*194232101).
1.Introduction Scientific breakthroughs enabled by artificial intelligence(Al)received unprecedented recognition with two Nobel Prizes awarded in 2024(Fig.1A).John Hopfield and Geoffrey Hinton,two pioneers of Al,were ...
关键词：BREAKTHROUGH jointly PIONEER 
Green analytical chemistry metrics for evaluating the greenness of analytical procedures
《Journal of Pharmaceutical Analysis》2024年第11期1542-1555,共14页Lei Yin Luyao Yu Yingxia Guo Chuya Wang Yuncheng Ge Xinyue Zheng Ning Zhang jiansong You Yong Zhang Meiyun Shi 
supported by the National Natural Science Foundation of China(Grant Nos.:81603182 and 81703607);the Fundamental Research Funds for the Central Universities,China(Grant Nos.:DUT24MS018,DUT23YG228,DUT21RC(3)057);the Open funding of Cancer Hospital of Dalian University of Technology,China(Grant No.:2024-ZLKF-33);the Natural Science Foundation of Liaoning Province,China(Grant No.:2023-MSBA-018).
Green analytical chemistry(GAC)focuses on mitigating the adverse effects of analytical activities on human safety,human health,and environment.In addition to the 12 principles of GAC,proper GAC tools should be develop...
关键词：Greenness metric Green analytical chemistry Analytical methods Environmental sustainability 
A holistic visualization for quality of Chinese materia medica: Structural and metabolic visualization by magnetic resonance imaging
《Journal of Pharmaceutical Analysis》2024年第11期1556-1566,共11页Jing Wu Kai Zhong Hongyi Yang Peiliang Zhang Nianjun Yu Weidong Chen Na Zhang Shuangying Gui Lan Han Daiyin Peng 
supported by Plans for Major Provincial Science&Technology Projects,China(Grant No.:202303a0702005);the National Natural Science Foundation of China(Grant Nos.:U19A2009 and 82304881);the Key Natural Science Research Projects in Anhui Universities,China(Grant Nos.:2022AH050484 and 2022AH010036);the Collaborative Innovation Project,China(Grant Nos.:GXXT-2019-043 and GXXT-2019-049).
The quality of Chinese materia medica(CMM)is a challenging and focused topic in the modernization of traditional Chinese medicine(TCM).A profound comprehension of the morphology,structure,active constituents,and dynam...
关键词：Chinese materia medica QUALITY Structure and metabolites VISUALIZATION Magnetic resonance imaging 
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
《Journal of Pharmaceutical Analysis》2024年第11期1567-1587,共21页Kai Yang Ping Zhang Jixin Li Genming Zhang Xing Chang 
Myocardial injury(MI)is a common occurrence in clinical practice caused by various factors such as ischemia,hypoxia,infection,metabolic abnormalities,and inflammation.Such damages are characterized by a reduction in m...
关键词：Natural products Endoplasmic reticulum stress Myocardial injury Unfolded protein response Cardiovascular disease 
SnoRNAs: The promising targets for anti-tumor therapy
《Journal of Pharmaceutical Analysis》2024年第11期1588-1602,共15页Xiaoyun Hu Wanlin Cui Min Liu Fangxiao Zhang Yingqi Zhao Mingrong Zhang Yuhang Yin Yalun Li Ying Che Xianglong Zhu Yuxuan Fan Xiaolan Deng Minjie Wei Huizhe Wu 
supported by grants from the National Natural Science Foundation of China(81872905,82272915,and 82073884);the Project of the Fourth Batch of Science and Technology Plan of Liaoning Province,China(Grant No.:2021JH210300133);Science and Technology Innovation Team Project of China Medical University,China(Grant No.:CXTD2022007);the Supporting the Highquality Development of Science and Technology Funding Projects at China Medical University(Grant No.:2022011963-JH2/202);China Postdoctoral Science Foundation(Grant No.:2023MD734246);Liaoning Province Natural Science Foundation Joint Fund(Grant No.:2023-MSLH-396)。
Recently,small nucleolar RNAs(snoRNAs)have transcended the genomic“noise”to emerge as pivotal molecular markers due to their essential roles in tumor progression.Substantial evidence indicates a strong association b...
关键词：SNORNA Cancer snoRNA host gene Multidrug resistance Targeted therapy Tumor immune microenvironment 
Recent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis
《Journal of Pharmaceutical Analysis》2024年第11期1603-1624,共22页Bibhu Prasad Nanda Priyanka Rani Priyanka Paul Aman Subrahmanya S.Ganti Rohit Bhatia 
An optical biosensor is a specialized analytical device that utilizes the principles of optics and light in bimolecular processes.Localized surface plasmon resonance(LSPR)is a phenomenon in the realm of nanophotonics ...
关键词：Localized surface plasmon resonance Surface-enhanced Raman spectroscopy Nanophotonic Biosensors Nanoparticles BIOMARKER Cancer 
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats被引量：1
《Journal of Pharmaceutical Analysis》2024年第11期1625-1644,共20页Junping Zhu Ye Lin Gejing Li Yini He Zhaoli Su Yuanyuan Tang Ye Zhang Qian Xu Zhongliu Yao Hua Zhou Bin Liu Xiong Cai 
funded by grants from the National Natural Science Foundation of China(Grant No.:82274506);the China Postdoctoral Science Foundation(Grant No.:2022M721128);the Science and Technology Innovation Program of Hunan,China(Grant No.:2021RC4035);the Natural Science Foundation of Hunan,China(Grant No.:2023JJ40477);the Open-competing Disciple Construction Project of Hunan University of Chinese Medicine(HNUCM),China(Grant No.:22JBZ003);was financially supported by the Furong Distinguished Scholar Program of Hunan,China(Program No.:XJT[2020]58);the 121 Training Project for Innovative Talents of Hunan,China(Project No.:XRSH[2019]192);the Chinese Academy of Engineering Academician Liang Liu's Workstation Project,China(Project No.:KH[2023]3-23YS001);the World First-class Discipline Incubation Project of HNUCM,China(Project No.:XJF[2022]57)。
Rheumatoid arthritis(RA)is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium.Currently,treatment options focus on either reducing inflammation or inhibiti...
关键词：Halofuginone hydrobromide Rheumatoid arthritis Nanocomplexes Macrophage polarization Rheumatoid arthritis fibroblast-like SYNOVIOCYTES Adjuvant-induced arthritis 
Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches
《Journal of Pharmaceutical Analysis》2024年第11期1645-1660,共16页Ravi Maharjan Ki Hyun Kim Kyeong Lee Hyo-Kyung Han Seong Hoon Jeong 
supported by the Advance Production of Vaccine Raw Materials(Grant Nos.:20022404 and 20018168)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea);supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(Grant No.:NRF-2018R1A5A2023127);Dongguk University Research Fund of 2023(Grant No.:S-2023-G0001-00099)。
To enhance the efficiency of vaccine manufacturing,this study focuses on optimizing the microfluidic conditions and lipid mix ratios of messenger RNA-lipid nanoparticles(mRNA-LNP).Different mRNA-LNP formulations(n=24)...
关键词：Vaccine manufacturing Microfluidic device XGBoost Bayesian optimization Self-validated ensemble model 
Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases
《Journal of Pharmaceutical Analysis》2024年第11期1661-1674,共14页Yongjing Zhang Yingnan Zeng Haoyun Bai Wen Zhang Zhuoyin Xue Shiling Hu Shemin Lu Nan Wang 
funded by National Natural Science Foundation of China(Grant Nos.:81930096 and 82274063).
Allergic inflammation is closely related to the activation of mast cells(MCs),which is regulated by its intracellular Ca^(2+) plevel,but the intake and effects of the intracellular Ca^(2+) premain unclear.The Ca^(2+) ...
关键词：ALLERGY ASTHMA Mast cell CaV1.2 CaMKII/PKC 
Comparative study of trastuzumab modification analysis using mono/ multi-epitope affinity technology with LC-QTOF-MS
《Journal of Pharmaceutical Analysis》2024年第11期1675-1685,共11页Chengyi Zuo Jingwei Zhou Sumin Bian Qing Zhang Yutian Lei Yuan Shen Zhiwei Chen Peijun Ye Leying Shi Mao Mu Jia-Huan Qu Zhengjin Jiang Qiqin Wang 
supported by the National Natural Science Foundation of China(Grant Nos.:82373829,82273893,and 82173773);the Natural Science Foundation of Guangdong Province,China(Grant Nos.:2021A1515220099,and 2022A1515011576);the High-End Foreign Experts Project,China(Grant No.:G2021199005L);the Science and Technology Program of Guangdong Provincial Medical Products Administration,China(Grant Nos.:2023TDZ11,and 2022ZDB04).
Dynamic tracking analysis of monoclonal antibodies(mAbs)biotransformation in vivo is crucial,as certain modifications could inactivate the protein and reduce drug efficacy.However,a particular challenge(i.e.immune rec...
关键词：Monoclonal antibody Multi-epitope affinity technology Biotransformation analysis LC-QTOF-MS Breast cancer 
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