DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金泰国研究基金更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2被引量：1
《Signal Transduction and Targeted Therapy》2023年第3期916-920,共5页Mengwen Huang Xingchao Pan Xinling Wang Qingfei Ren Bei Tong Xianchi Dong Gaoxiang Ge Lu Lu Shibo Jiang Jianfeng Chen 
This research was supported by the National Key R&D Program of China(2020YFA0509000 to J.C.);the National Natural Science Foundation of China(32030024,31830112,and 31525016 to J.C.,92169112 and 82161138002 to S.J.);Program of Shanghai Academic Research Leader(19XD1404200);Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to S.J);National Ten Thousand Talents Program.The authors gratefully acknowledge the support of the SA-SIBS scholarship program.
Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of COVID-19.Lymphopenia is associated with increased disease severity in COVID-19.Significa...
关键词：SEVERITY infection prognosis 
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors
《Signal Transduction and Targeted Therapy》2022年第1期270-281,共12页Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei 
This study was supported by the joint emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology of China,Guangdong Science and Technology Department and Guangzhou Municipal Science and Technology Bureau(2020B111108001);Guangdong Science and Technology Department(2020B121206001&2020B1212030004);The funders had no role in study design,data collection and analysis,or preparation of the manuscript.
Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-relat...
关键词：metabolism mechanism resistance 
The circFASN/miR-33a pathway participates in tacrolimusinduced dysregulation of hepatic triglyceride homeostasis被引量：4
《Signal Transduction and Targeted Therapy》2020年第1期2132-2141,共10页Chenzhi Zhang Kangchen Chen Rongli Wei Guanghan Fan Xuechun Cai Li Xu Beini Cen Jianguo Wang Haiyang Xie Shusen Zheng Xiao Xu 
supported by the National Natural Science Foundation of China(General Program)[Grant number:81570589];the National Natural Science Funds for Distinguished Young Scholars of China[Grant number:81625003];the National Natural Science Foundation of China(Key Program)[Grant number:81930016];the Cheung Kong Scholars Program of China and National Science and Technology Major Project[Grant number:2017ZX100203205].
Dyslipidemia exhibits a high incidence after liver transplantation,in which tacrolimus,a widely used immunosuppressant,plays a fundamental role.MicroRNAs and related circRNAs represent a class of noncoding RNAs that h...
关键词：TACROLIMUS HOMEOSTASIS ELEVATED 
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