THERAPY

作品数：3109被引量：9914H指数：32
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A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy
《Bioactive Materials》2024年第12期165-177,共13页Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang 
supported by the Shenzhen Science and Technology Program-Basic Research Scheme(JCYJ20220531090808020);the Research Grants Council(RGC)of Hong Kong Collaborative Research Grant(C5005-23W and C5078-21E);the Research Grants Council(RGC)of Hong Kong General Research Grant(PolyU 15217621 and PolyU 15216622);the Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/032/20SZ and SGDX20201103095404018);the Hong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund(I2022A002);PolyU Internal Fund(1-YWB4,1-WZ4E,1-CD8M,1-WZ4E,1-CEB1,1-YWDU,1-CE2J and 1-W02C);the funding from the Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center(No.:LMDBCXRC202401 and LMDBCXRC202402);Shandong Provincial Overseas Excellent Young Scholar Program(2024HWYQ-042 and 2024HWYQ-043);Taishan Scholar Youth Expert Program of Shandong Province(tsqn202306102 and tsqn202312105)supporting this work;supported by the University Research Facility in Life Sciences of the Hong Kong Polytechnic University.
Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen speci...
关键词：Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease 
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment
《Bioactive Materials》2024年第12期379-403,共25页Yun Chang Mingyang Chang Xiaoping Bao Cheng Dong 
supported by start-up package funding from The Hong Kong Polytechnic University(Y.C.).
Adoptive immunotherapy,notably involving chimeric antigen receptor(CAR)-T cells,has obtained Food and Drug Administration(FDA)approval as a treatment for various hematological malignancies,demonstrating promising prec...
关键词：Adoptive cellular immunotherapy Immune cell engineering Multiple-model synergistic therapy Tumor microenvironment 
STAT3-specific nanocarrier for shRNA/drug dual delivery and tumor synergistic therapy
《Bioactive Materials》2024年第11期137-157,共21页Le Sun Jishang Sun Cuiyao Li Keying Wu Zhiyang Gu Lan Guo Yi Zhou Baoqin Han Jing Chang 
Shandong Provincial Key Research and Development Program(Major Scientific and Technological Innovation Project,No.2022CXGC010505);National Natural Science Foundation of China(No.51773188);National Key Research and Development Program of China(No.2023YFC2812004);Key Project of Natural Science Foundation of Shandong Province(No.ZR2020KE016).
Non-small cell lung cancer(NSCLC)is a major disease with high incidence,low survival rate and prone to develop drug resistance to chemotherapy.The mechanism of secondary drug resistance in NSCLC chemotherapy is very c...
关键词：Synergistic therapy Short hairpin RNA STAT3 signaling pathway Drug delivery Tumor treatment 
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence
《Bioactive Materials》2024年第10期474-483,共10页Wanying Li Yinghui Wang Chaojie Che Xinyu Fu Yang Liu Dongzhi Xue Shuai Zhang Rui Niu Hao Zhang Yue Cao Shuyan Song Liren Cheng Hongjie Zhang 
supported by the financial aid from the Basic Science Center Project of the National Natural Science Foundation of China(22388101);National Natural Science Foundation of China(Grant Nos.22020102003,U23A20581,52272169,and 52022094);National Key R&D Program of China(2020YFA0712102);the Program of Science and Technology Development Plan of Jilin Province of China(No.20230508071RC);the Youth Innovation Promotion Association of Chinese Academy of Sciences (Grant 2019232).
Invasive tumors are difficult to be completely resected in clinical surgery due to the lack of clear resection margins,which greatly increases the risk of postoperative recurrence.However,chemotherapy and radiotherapy...
关键词：Magnesium alloy Gas therapy Mild magnetic hyperthermia therapy Postsurgical tumor recurrence 
Targeting nanoplatform synergistic glutathione depletion-enhanced chemodynamic,microwave dynamic,and selective-microwave thermal to treat lung cancer bone metastasis
《Bioactive Materials》2024年第9期544-561,共18页Man Shu Jingguang Wang Ziyang Xu Teliang Lu Yue He Renshan Li Guoqing Zhong Yunbo Yan Yu Zhang Xiao Chu Jin Ke 
support from National Natural Science Foundation of China(U21A2084);National Key Research and Development Program of China(2021YFC2400704).
Once bone metastasis occurs in lung cancer,the efficiency of treatment can be greatly reduced.Current mainstream treatments are focused on inhibiting cancer cell growth and preventing bone destruction.Microwave ablati...
关键词：MgFe_(2)O_(4)@ZOL nanoparticles TARGETING Chemodynamic therapy Microwave dynamic therapy Microwave thermal therapy 
Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair
《Bioactive Materials》2024年第8期374-383,共10页Nailin Yang Xiaoyuan Yang Shuning Cheng Xiang Gao Shumin Sun Xuan Huang Jun Ge Zhihui Han Cheng Huang Yuanjie Wang Chong Cheng Liang Cheng 
supported by the National Key Research and Development Program of China(2022YFB3804600,2021YFF0701800);the National Natural Science Foundation of China(U20A20254,52072253);the Science and Technology Development Fund,Macao SAR(0118/2023/RIA2);Collaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544);the 111 Project,Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,Medical Research Project of Jiangsu Province(ZD2022024);New Cornerstone Science Foundation through the XPLORER PRIZE,and Key Laboratory of Structural Deformities in Children of Suzhou(SZS2022018);N.Y.was supported by the Macao Young Scholars Program and the Jiangsu Funding Program for Excellent Postdoctoral Talent.
Implant-related osteomyelitis is a formidable hurdle in the clinical setting and is characterized by inflammation,infection,and consequential bone destruction.Therefore,effective reactive oxygen species(ROS)scavenging...
关键词：Magnesium implants Bacterial infection Alternating magnetic field Gas therapy Proton consumption ANTI-INFLAMMATORY 
Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors
《Bioactive Materials》2024年第6期376-412,共37页Hao Li Shuai Wang Zhengqiang Yang Xianwei Meng Meng Niu 
supported by National Natural Science Foundation of China,62371474(MN);Natural Science Foundation of Liaoning Province,2023JH2/101600006(MN).
The treatment of digestive system tumors presents challenges,particularly in immunotherapy,owing to the advanced immune tolerance of the digestive system.Nanomaterials have emerged as a promising approach for addressi...
关键词：Digestive system tumors Tumor-associated macrophages NANOMATERIALS Tumor immune microenvironment THERAPY 
A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration
《Bioactive Materials》2024年第5期99-121,共23页Ashkan Bigham Ines Fasolino Silvia Borsacchi Carmen Valente Lucia Calucci Gabriele Turacchio Marianna Pannico Manuel Serrano-Ruiz Luigi Ambrosio Maria Grazia Raucci 
support from Progetto MIUR PRIN2017-ACTION,Grant No.2017SZ5WZB and POR Campania FESR 2014-2020(Campania imaging Infrastructure for Research in Oncology-C.I.R.O);The authors also thank Maria Rosaria Bonetti for lab technical support,Cristina Del Barone for facilitating microscopy analysis,Dr.Antonio Pennetta for ICP analysis and Dr.Roberta Marzella for support to project management.CISUP(Centre for Instrument Sharing-University of Pisa)and the EUroBioImaging(EUBI)Facility at CNR(Naples)are acknowledged for the use of the Bruker Avance NEO 500 Solid State NMR spectrometer and of AxioVision microscope(Carl Zeiss Micro Imaging GmbH),respectively.
Recently,the term theragenerative has been proposed for biomaterials capable of inducing therapeutic approaches followed by repairing/regenerating the tissue/organ.This study is focused on the design of a new theragen...
关键词：Bioactive glass Black phosphorus Microwave treatment Bone cancer therapy Tissue regeneration 
Intelligent nanoreactor coupling tumor microenvironment manipulation and H_(2)O_(2)-dependent photothermal-chemodynamic therapy for accurate treatment of primary and metastatic tumors被引量：1
《Bioactive Materials》2024年第4期354-365,共12页Jie Liu Tianfeng Yang Handan Zhang Lin Weng Xiuhong Peng Tao Liu Cheng Cheng Yanmin Zhang Xin Chen 
supported by the National High Level Talents Special Support Plan(X.C.);the National Natural Science Foundation of China(82272141 to X.C.);the“Young Talent Support Plan”of Xi’an Jiaotong University(X.C.);the Shaanxi Innovative Research Team of Science and Technology(S2023-ZC-TD-0152);the Natural Science Foundation of Shaanxi Province(2022JZ-48 to X.C.);the National Key Research and Development Program of China(2023YFC2509104 to X.C.);the Postdoctoral Science Foundation of China(2023M732812 to T.L.).
Tumor microenvironment(TME),as the“soil”of tumor growth and metastasis,exhibits significant differences from normal physiological conditions.However,how to manipulate the distinctions to achieve the accurate therapy...
关键词：NANOREACTOR H_(2)O_(2)-dependent Photothermal-chemodynamic therapy Copper depletion Tumor metastasis inhibition 
pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy被引量：1
《Bioactive Materials》2024年第4期414-421,共8页Jianhua Zou Zheng Li Yang Zhu Yucen Tao Qing You Fangfang Cao Qinghe Wu Min Wu Junjie Cheng Jianwei Zhu Xiaoyuan Chen 
the National University of Singapore(NUHSRO/2020/133/Startup/08,NUHSRO/2023/008/NUSMed/TCE/LOA,NUHSRO/2021/034/TRP/09/Nanomedicine);National Medical Research Council(MOH-001388-00,MOH-001041,CG21APR1005);Singapore Ministry of Education(MOE-000387-00);National Research Foundation(NRF-000352-00);the Open Fund Young Individual Research Grant of Singapore(MOH-001127-01).
Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy(PDT)due to oxygen consumption.Type I PDT,which can operate independently of oxygen,is a viable option for treating hypoxic tumors....
关键词：TME responsive NO gas therapy NIR-II imaging Type I PDT 
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