supported by a National Key Research and Development Project Grant(2021YFC2300502);the National Natural Science Foundation of China Grants(32370930 and 32360176).
Leucine-rich repeat kinase 2(Lrrk2)has received widespread attention as a risk gene associated with Parkinson’s disease.As the immune response attributes of Parkinson’s disease have been gradually revealed,the link ...
This is a correction to:Hao Wang,Junbo Yang,Yihong Cai,Yang Zhao,Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFNmediated intercellular self-stimulating circuit,Protein&Cell,2024;pwae013,https...
supported by the Biological Breeding-Major Projects(2023ZD04065)。
Type Ⅳ interferon(IFN-υ)is a recently discovered cytokine crucial for host defense against viral infections.However,the role and mechanisms of IFN-υin bacterial infections remain unexplored.This study investigated ...
National Natural Science Foundation of China(31970844,32170927)to SDX.
Type I interferon(IFN-I)exhibits broad-spectrum antiviral properties and is commonly employed in clinical for the treatment of viral infections.In this study,we unveil SENP6 as a potent regulator of IFN-I antiviral ac...
supported by National Key Research and Development Program of China 2023YFC3404600;National Natural Science Foundation of China grant(82371848)。
As a key sensor of double-stranded DNA(dsDNA),cyclic GMP-AMP synthase(cGAS)detects cytosolic dsDNA and initiates the synthesis of 2′3′cyclic GMP-AMP(cGAMP)that activates the stimulator of interferon genes(STING).Thi...