OLIGODEOXYRIBONUCLEOTIDES

作品数：7被引量：35H指数：2
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相关领域：医药卫生更多>>
相关作者：陈高飞尹文朱金文冯洋更多>>
相关机构：第四军医大学西京医院更多>>
相关期刊：《中国急救医学》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金中国博士后科学基金陕西省自然科学基金更多>>
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dsODNs 靶向封闭肺泡巨噬细胞中 NF -κB炎症信号通路的实验研究
《中国急救医学》2014年第8期724-728,共5页冯洋 尹文 朱金文 陈高飞 
国家自然科学基金项目（81070063）;陕西省自然科学基础研究计划项目（2014JM4186）
目的：在确定脂质体转染双链寡聚脱氧核苷酸（ dsODNs ）最佳转染浓度及时间的基础上，评估脂质体转染的双链寡聚脱氧核苷酸（ dsODNs/Lipofectamin2000）竞争性抑制对肺泡巨噬细胞中核因子κB（ NF-κB）/DNA结合活性的影响，验证dsODN...
关键词：核因子-κB(NF-κB) 双链寡聚脱氧核甘酸(dsODNs) 肺泡巨噬细胞(AMs) Nuclear factor-κB (NF-κB) Double STRANDS OLIGODEOXYRIBONUCLEOTIDES (dsODNs) Alveolar macrophages (AMs) 
Effects of CpG-ODN on gene expression in formation of foam cells
《Acta Pharmacologica Sinica》2005年第11期1359-1364,共6页Kai LI Bin WAN Zhen-lin HU Ying HE Xiao-wen HE Lei JIANG Shu-han SUN 
Project supported by the National Natural Science Foundation of China (№ 30370741).
Aim： To investigate the effects of CpG-oligodeoxynucleotide （CpG-ODN） on the formation of macrophage foam cells and related gene expression. Methods： A gene expression profile was examined by microarray techniques...
关键词：CpG islands OLIGODEOXYRIBONUCLEOTIDES foam cells macrophages LDL lipoprotein gene expression CHOLESTEROL CD 36 antigens lipoprotein lipase Fc gamma receptor IIb 
Combination and cleavage of HBV DNA fragments by triple helix-forming oligonucleotides modified with manganese porphyrin in vitro被引量：1
《Chinese Medical Journal》2003年第8期1248-1252,共5页光丽霞 袁发焕 奚敏 赵聪敏 刘立 温恩懿 艾友萍 
ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 3 980 0 12 8)
Objective To observe the ability of triple helix-forming oligonucleotides (TFOs) modified with manganese porphyrin to combine with and cleave HBV DNA fractions. Methods TFO were modified with manganese porphyrin and...
关键词：oligodeoxyribonucleotides·hepatitis B virus·manganese·porphyrins·acridines 
Design and choice of TFO binding and cleaving HBV core promoter
《Journal of Medical Colleges of PLA(China)》2003年第1期36-41,共6页光丽霞 袁发焕 任平 奚敏 艾友平 
Objective: To screen a triple helix-forming oligodeoxyribonucleotide (TFO) that can bind HBV core promoter at target site with high affinity and specificity, and to observe the ability of manganese porphyrin modified ...
关键词：triple helix-forming oligodeoxyribonucleotides hepatitis B virus triplex DNA 
Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity被引量：13
《Cell Research》2001年第2期107-115,共9页SunHZ WuSF 
A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection. Insulin-like growth factor 1 receptor (IGF-1R) signa...
关键词：Antibiotics  Antineoplastic Apoptosis Autocrine Communication Bladder Neoplasms Carcinoma  Transitional Cell Cell Division CYTOTOXINS Drug Resistance  Neoplasm Gene Expression Regulation  Neoplastic Gene Targeting Humans Insulin-Like Growth Factor I Insulin-Like Growth Factor II Microscopy  Electron MITOMYCIN Oligodeoxyribonucleotides  Antisense Protein Synthesis Inhibitors RNA  Messenger Receptor  IGF Type 1 Signal Transduction Tumor Cells  Cultured 
Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice被引量：21
《World Journal of Gastroenterology》2001年第3期345-351,共7页Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. 
Supported by the National Postdoctoral Science Foundation of China,No.199711.
AIM: To evaluate antihepatoma effect of antisense phosphorothioate oligodeoxyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nude mice. METHODS: AFP gene expression was examined by i...
关键词：Animals Apoptosis Carcinoma  Hepatocellular Gene Expression Gene Therapy Humans In Vitro Liver Neoplasms Male MICE Mice  Inbred BALB C Mice  Nude Neoplasm Transplantation Oligodeoxyribonucleotides  Antisense Research Support  Non-U.S. Gov't Transplantation  Heterologous Tumor Cells  Cultured ALPHA-FETOPROTEINS 
PREPARATION AND CLEAVAGE MECHANISM OF CHELATES OF METAL IONS WITH EDTA LINKED TO OLIGODEOXYRIBONUCLEOTIDES
《Journal of Central South University》1998年第1期47-50,共4页Li Xiaoru(Department of Chemistry, Central South University of Technology,Changsha 410083,China)Wen Zhibin(Department of Basic Medicine,Hunan Medical University,Changsha 410078,China) 
The chelates of metal ions with EDTA covalently linked to the 5′end of oligodeoxyribonuclotides(ODN),i.e,ODN5′EDTA·M(Ⅱ),are prepared,in which M(Ⅱ) is Fe(Ⅱ),Co(Ⅱ) or Cu(Ⅱ).The optimum pH value for forming these...
关键词：Oligodeoxyribonucleotide METAL IONS chelate cleavage 
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