COPY-NUMBER

作品数:7被引量:18H指数:3
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相关领域:医药卫生更多>>
相关期刊:《Neuroscience Bulletin》《The Crop Journal》《Journal of Bio-X Research》《World Journal of Gastroenterology》更多>>
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Single-cell profiling of the copy-number heterogeneity in colorectal cancer
《Chinese Medical Journal》2023年第6期707-718,共12页Shiyu Song Lin Feng Kexing Xi Zhigang Sun Deyang Kong Zhenkai Luo Wei Pei Haizeng Zhang 
Background:With functionally heterogeneous cells,tumors comprise a complex ecosystem to promote tumor adaptability and evolution under strong selective pressure from the given microenvironment.Diversifying tumor cells...
关键词:Somatic copy number alteration Microsatellite stable Colorectal cancer Single cell RNA-sequencing Intra-tumor genetic heterogeneity 
Aneuploidy:An opportunity within single-cell RNA sequencing analysis
《BIOCELL》2021年第5期1167-1170,共4页JOE R.DELANEY 
NIH NCI Grant[CA207729](JD).
Single-cell sequencing data has transformed the understanding of biological heterogeneity.While many flavors of single-cell sequencing have been developed,single-cell RNA sequencing(scRNA-seq)is currently the most pro...
关键词:scRNA-seq Copy-number alterations ANEUPLOIDY Cancer 
The role of genomic structural variation in the genetic improvement of polyploid crops被引量:5
《The Crop Journal》2019年第2期127-140,共14页Sarah-Veronica Schiessl Elvis Katche Elizabeth Ihien Harmeet Singh Chawla Annaliese S.Mason 
supported by the Deutsche Forschungsgemeinschaft(MA6473/1-1,MA6473/2-1)
Many of our major crop species are polyploids, containing more than one genome or set of chromosomes. Polyploid crops present unique challenges, including difficulties in genome assembly, in discriminating between mul...
关键词:Presence–absence VARIATION COPY-NUMBER VARIATION Homeologous exchanges Genome structure PAN-GENOME 
Genomic mutation signatures in primary breast cancer and their axillary metastatic lymph nodes被引量:1
《Journal of Bio-X Research》2019年第1期34-40,共7页Xiangzhi Meng Wenyan Wang Jiaqi Liu Shan Zheng Changyuan Guo Jie Wang Zeyu Xing Menglu Zhang Kexin Feng Xin Wang Xiang Wang 
This research was funded in part by the National Natural Science Foundation of China(81602343 to Xin Wang);the Chinese Academy of Medical Sciences(CAMS)initiative Fund for Medical Sciences,China(2016-I2M-1-001 to Xiang Wang,2017-I2M-3-004 to Xin Wang);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,China(2018PT32013,2017PT32001 and 2016ZX310178 to Xin Wang);the Beijing Hope Run Special Fund,China(LC2017B15 to Xin Wang);the Capital’s Funds for Health Improvement and Research,China(2016-4-4026 to Xin Wang);Youth Research Fund of Beijing Tiantan Hospital,China(2017-YQN-09 to Wenyan Wang).
Breast cancer is one of the most common malignant tumors in women all over the world.Metastasis represents a major adverse progression of breast cancer,resulting in poor survival duration.Axillary lymph node metastasi...
关键词:breast cancer copy-number variants genomic signature lymph node metastasis multi-clonal mutation single nucleotide variants whole exome sequencing 
Metabolomic alterations and chromosomal instability status in gastric cancer被引量:8
《World Journal of Gastroenterology》2018年第33期3760-3769,共10页Cheng-Kun Tsai Ta-Sen Yeh Ren-Chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu Cheng-Yu Hung Hung-Yao Ho Mei-Ling Cheng Gigin Lin 
Supported by the Ministry of Science and Technology Taiwan grant,No.MOST 106-2314-B-182A-019-MY3;the Chang Gung Foundation,No.CMRPG3E1321-2,No.IRB201601916B0,and No.IRB103-7448B
AIM To explore the correlation of metabolomics profiles ofgastric cancer(GC) with its chromosomal instability(CIN) status.METHODS Nineteen GC patients were classified as CIN and nonCIN type by The Cancer Genome Atlas ...
关键词:GASTRIC cancer Metabolomics ONCOGENE COPY-NUMBER CHROMOSOMAL instability Liquid chromatography-mass SPECTROMETRY 
Genetic studies of schizophrenia:an update被引量:4
《Neuroscience Bulletin》2015年第1期87-98,共12页Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen 
supported by the National Institutes of Health,USA (MH101054)
Schizophrenia(SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variant...
关键词:schizophrenia genome-wide association study copy-number variant de novo mutation sequencing genetics 
A proteomic approach to investigate the qualitative and quantitative polymorphism of <i>β</i>-lactoglobulin in ovine milk: Inference on gene copy-number variations
《Advances in Biological Chemistry》2012年第3期207-217,共11页G. Picariello A. Di Luccia P. Ferranti I. Alloggio F. Addeo E. Pieragostini 
The rationale of this work is based on recent evidences suggesting that: 1) both qualitative and quantitative β-lactoglobulin (β-LG) polymorphism may be found in bovine milk;2) quantitative polymorphisms are often t...
关键词:QUANTITATIVE POLYMORPHISM β-Lactoglobulin HPLC-ESI MS MALDI-TOF Mass Mapping GENE Duplication GENE Arrangements COPY-NUMBER Variations (CNVs) 
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