AGONISTIC

作品数：28被引量：56H指数：4
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Multiplex analysis platform for evaluation of endocrine disruption of emerging contaminants against human steroid hormone receptors using autobioluminescent yeast bioassay:Application to bisphenols
《Emerging Contaminants》2024年第4期132-144,共13页Yuan Huang Wei Zhang Ruiguo Wang Zhiming Xiao John P.Giesy Liming Wu Xiaoou Su 
supported by the National Key Research and Development Program of China(NO.2023YFD1301505,No.2017YFC1600303);the Agricultural Science and Technology Innovation Program of CAAS(CAAS-ASTIP-IQSTAP-04);Prof.Giesy was supported by the Canada Research Chair program,the 2012"High Level Foreign Experts"(#GDT20143200016)program,funded by the State Administration of Foreign Experts Affairs,the P.R.China to Nanjing University and the Einstein Professor Program of the Chinese Academy of Sciences and a Distinguished Visiting Professorship in the Department of Environmental Sciences,Baylor University in Waco,TX,USA.
Emerging synthetic or derivative chemicals have drawn global concern due to their potential endocrine-disrupting effects,either as agonists or antagonists or through indirect effects on enzymes of signal transduction ...
关键词：teroid hormone receptors YEAST Agonistic activity Antagonistic activity BISPHENOLS Endocrine-disrupting 
Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent
《Bioactive Materials》2024年第11期485-498,共14页Jing Chen Changyi Zhou Weilun Fang Jiasheng Yin Jian Shi Junbo Ge Li Shen Shi-Ming Liu Shao-Jun Liu 
National Natural Science Foundation of China(82170413,82170342,82200377);Guangdong Basic and Applied Basic Research Foundation(2021A1515012546,2022A1515012474);Shanghai Yangfan Project(21YF1440000);Innovation Team of General Universities in Guangdong Province(2023KCXTD025);Guangzhou Science and Technology Plan(202102010101,202201020220);Student Innovation Program of Guangzhou Medical University(to S.J.L.).
The commercially available drug-eluting stent with limus (rapamycin, everolimus, etc.) or paclitaxel inhibits smooth muscle cell (SMC), reducing the in-stent restenosis, whereas damages endothelial cell (EC) and delay...
关键词：EPCR REENDOTHELIALIZATION Agonistic target Eluting stent Stent thrombosis 
BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models
《Frontiers of Medicine》2023年第6期1170-1185,共16页Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wang Ye Liu 
t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation an...
关键词：BGB-A445 OX40 agonistic antibody OX40L noncompetitive 
First Recorded Account of a White Shark Agonistic Pectoral Fin Depression Behavior at Guadalupe Island, Mexico
《Open Journal of Animal Sciences》2023年第3期263-271,共9页Andrew Currie Ralph S. Collier 
An agonistic display by a white shark was observed and photographed during a cage dive at Guadalupe Island in November 2015. Exhibiting exaggerated pectoral fin depression, agonistic behaviors have been previously obs...
关键词：White Shark Ocean Agonistic Behavior Pectoral Fin Depression Cage Diving Guadalupe Island 
Applanoids A—E as the First Examples of C-15/C-20 Michael Adducts in Ganoderma Triterpenoids and Their PXR Agonistic Activity被引量：1
《Chinese Journal of Chemistry》2022年第22期2633-2641,共9页Hai-Guo Su Hang-Fei Liang Gui-Lin Hu Lin Zhou Xing-Rong Peng Hui-Chang Bi Ming-Hua Qiu 
supported by the Basic Research Project of Yunnan Province(202001AT070070);the Youth Innovation Promotion Association of CAS(2019383);the Natural Science Foundation of China(Nos.82025034,81973392,81973195 and 82104020);the Shenzhen Science and Technology Program(No.KQTD20190929174023858).
Ganoderma triterpenoids(GTs),a class of major active constituents of Ganoderma fungi,possess diverse structures and remarkable activities.In the present study,nine new GTs,namely applanoids A—I(1—9),were isolated fr...
关键词：Ganoderma applanatum Lanostane triterpenoids Michael adducts Structure elucidation Pregnane X receptor 
Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation被引量：1
《Chinese Journal of Chemistry》2021年第5期1288-1296,共9页Zhi-Lin Luan Fei Qiao Wen-Yu Zhao Wen-Hua Ming Zhen-Long Yu Jie Liu Sheng-Yun Dai Shuang-Hui Jiang Chao-Jie Lian Cheng-Peng Sun Bao-Jing Zhang Jian Zheng Shuang-Cheng Ma Xiao-Chi Ma 
the National Natural Science Foundation of China(No.81703679);the Liaoning Provincial Key Research and Development Program(No.2019JH2/10300022);the Natural Science Foundation of Liaoning Province(No.2020-MS-256);the Dalian Young Star of Science and Tech nology(Nos.2019RQ123 and 2019RQ116).
The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were c...
关键词：Morinda officinalis IRIDOID Farnesoid X receptor Agonistic effect 
UFLC‑PDA‑MS/MS Profling of Seven Uncaria Species Integrated with Melatonin/5‑Hydroxytryptamine Receptors Agonistic Assay被引量：1
《Natural Products and Bioprospecting》2020年第1期23-36,共14页Jian-Gang Zhang Xiao-Yan Huang Yun-Bao Ma Ji-Jun Chen Chang-An Geng 
supported by the National Natural Science Foundation of China(81573322);the Yunnan Wanren Project(YNWR-QNBJ-2018-061);the Youth Innovation Promotion Association,CAS(2013252);the Program of Yunling Scholarship,the Yunnan Science Fund for Excellent Young Scholars(2019FI017)。
Uncariae Ramulus Cum Uncis(Gou-Teng),the dried hook-bearing stems of several Uncaria plants(Rubiaceae),is a wellknown herbal medicine in China.The clinical application of Gou-Teng is bewildered for the morphological a...
关键词：Uncariae Ramulus Cum Uncis Uncaria plants LCMS-IT-TOF analyses Melatonin and 5-hydroxytryptamine receptors 
Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata被引量：8
《Natural Products and Bioprospecting》2019年第4期297-302,共6页Si‑Yue Chen Chang‑An Geng Yun‑Bao Ma Ji‑Jun Chen 
This work was supported by the Program of Yunling Scholar,the Youth Innovation Promotion Association,CAS(2013252);the Applied Basic Research Programs of Yunnan Province(2017FB137).
Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application.In this study,three new polybenzyls,gastropolybenzylols G-I(1-3)were isolated from the EtOAc extract of G.elata.Their structur...
关键词：Gastrodia elata Gastropolybenzylols Melatonin receptors 
Factors affecting the dominance hierarchy dynamics in a hummingbird assemblage
《Current Zoology》2019年第3期261-268,共8页Ubaldo MARQUEZ-LUNA Carlos Lara Pablo CORCUERA Pedro Luis VALVERDE 
Intra and in terspecific competiti on for n ectar play an imports nt role in hummingbird communities. Larger sized species usually exclude smaller species from the rich floral resources. However, it has been recently ...
关键词：AGONISTIC behavior COMPETITION HUMMINGBIRDS resource quality TERRITORIALITY 
Agonistic Memory,Compound Temporality and Expansion of Literary Space in Lu Xun被引量：1
《Frontiers of Literary Studies in China-Selected Publications from Chinese Universities》2019年第2期200-261,共62页Xudong ZHANG 
The paper examines the ways in which memory is constructed in Lu Xun's writings, above all his essay (zawen) by means of an artistic staging of its antagonism with forgetting. The author emphasizes the primacy of forg...
关键词：memoire involontaire MODERNISM the essay (zdwen) FORGETTING representation METAPHYSICS of hope 
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