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作品数:305被引量:613H指数:10
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Reduced interleukin-2 receptor subunitγexpression in Crohn's disease:A potential mechanism forγδT cell deficiency
《World Journal of Gastroenterology》2025年第13期152-154,共3页Md Sadique Hussain Ajay Singh Bisht Gaurav Gupta 
Crohn’s disease(CD)is a chronic inflammatory disorder characterized by dysregulated immune responses and significant disruption of intestinal immunity.A recent case-control study by Andreu-Ballester et al revealed de...
关键词:Crohn's disease Gastrointestinal immunology Interleukin-2 receptorγsubunit(CD132) Interleukin-7/interleukin-2 signaling pathway Immune regulation Immune signaling T cell apoptosis 
COPB2 promotes hepatocellular carcinoma progression through regulation of YAP1 nuclear translocation
《Oncology Research》2025年第4期975-988,共14页BIAO WU XIANLIN GUO ZHISHI WU LIANG CHEN SUQING ZHANG 
Objectives:Although Yes-associated protein 1(YAP1)is an important oncogene in hepatocellular carcinoma(HCC)progression,its nuclear localization prevents it from being considered a potential therapeutic target.Recently...
关键词:Coatomer protein complex subunit beta 2(COPB2) Yes-associated protein 1(YAP1) Hepatocellular carcinoma(HCC)prognosis Cisplatin(DDP) 
NARROW AND ROLLED LEAF 9,a Novel Gene Encoding 20S Proteasome β1 Subunit that Regulates Leaf Morphology and Grain Size in Rice
《Rice science》2025年第2期143-146,I0004-I0015,共16页KANG Fengyu ZHOU Liang CHEN Wenqiang# HUANG Pingliang Amos Musyoki MAWIA LUO Ju HU Peisong 
supported by the National Major Science and Technology Program on New Genetically Modified Organism Variety Breeding,China(Grant No.2016ZX08001-001).
Rice leaf morphology is of great significance in the breeding of an ideal plant type and high photosynthetic efficiency.A forward genetics approach was employed to locate a novel gene,NRL9(NARROW AND ROLLED LEAF 9).NR...
关键词:BREEDING GRAIN ROW 
Decreased gene expression of interleukin 2 receptor subunitγ(CD132)in tissues of patients with Crohn’s disease
《World Journal of Gastroenterology》2025年第12期14-26,共13页Juan Carlos Andreu-Ballester Carolina Hurtado-Marcos Carlos García-Ballesteros Jaime Pérez-Griera Fernando Izquierdo Dolores Ollero Ana Jiménez Rafael Gil-Borrás Antonio Llombart-Cussac Francisca López-Chuliá Carmen Cuéllar 
A deficiency ofγδT cells has been described in Crohn's disease(CD).AIM To analyze the gene expression of interleukin 7(IL-7)and its receptors in the tissues of patients with CD.METHODS We studied the peripheral bloo...
关键词:Crohn’s disease Interleukin 7 Interleukin 2 receptor subunitγ(CD 132) Caspase-3 γδT cells 
Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第2期76-93,共18页Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei 
Supported by National Natural Science Foundation of China,No.82160762;Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230267;China Undergraduate Innovation and Entrepreneurship Training Program,No.S202410598060X;China Undergraduate Innovation and Entrepreneurship Training Program,No.X202410598360;Future Academic Star of Guangxi Medical University,No.WLXSZX24074.
BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on th...
关键词:Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing 
The proteasome activator subunit PSME1 promotes HBV replication by inhibiting the degradation of HBV core protein
《Genes & Diseases》2024年第6期395-408,共14页Yu Liu Jiaxin Yang Yanyan Wang Qiqi Zeng Yao Fan Ailong Huang Hui Fan 
supported by the National Key R&D Program of China (No.2022YFA1303600).
Chronic hepatitis B virus(HBV)infection is a leading cause of liver cirrhosis and he-patocellular carcinoma,representing a global health problem for which a functional cure is difficult to achieve.The HBV core protein...
关键词:26S proteasome APEX2 HBC HBV Host-viral interactions PSME1 
Collagen prolyl 4-hydroxylase subunitαmember-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via reduced expression of occludin
《Acta Biochimica et Biophysica Sinica》2024年第12期1833-1847,共15页Miao Xu Run Shi Jie Yang Heng Chen Shihua Liu Shupei Yu Sasa Li Wenqiang He Man-Sun Sy Mingjian Lu Huixia Zhang Chaoyang Li 
supported by the grants from the National Natural Science Foundation of China(Nos.32070147,30670170 and 32470172 to C.L.);the MOST(No.2018YFA0507201 to C.L.),the Science and Technology Program from Forestry Administration of Guangdong(No.2024KJCX020 to C.L.);the Pingdingshan College PhD Startup Fund(No.PXY-BSQD-2024007 to R.S.).
There are three isoforms of human collagen prolyl 4-hydroxylases(C-P4Hs),each of which has been reported to play an important role in regulating the progression of a variety of human cancers.By analyzing TGCA datasets...
关键词:HNSC P4HAs LLGL2 OCCLUDIN prognosis 
Energy deprivation-induced autophagy and aggrephagy:insights from yeast and mammals
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1066-1070,共5页Siyu FAN Yingcong CHEN Weijing YAO Cong YI 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LR21C070001);the National Natural Science Foundation of China(Nos.32122028,92254307,32070739,and 32100600)。
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physio...
关键词:AUTOPHAGY Glucose starvation Solid aggrephagy Chaperonin-containing TCP-1 subunit 2(CCT2) 
MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons被引量:5
《Neural Regeneration Research》2024年第12期2698-2707,共10页Bhupender Sharma Melissa MTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar 
supported by the National Institute on Aging (NIA);National Institutes of Health (NIH);Nos.K99AG065645,R00AG065645;R00AG065645-04S1 (to SK);NIH research grants,NINDS,No.R01 NS115834;NINDS/NIA,No.R01 NS115834-02S1 (to LG)。
Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-rel...
关键词:Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization PATCH-CLAMP 
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants
《Signal Transduction and Targeted Therapy》2024年第12期5752-5764,共13页Hong Lei Weiqi Hong Jingyun Yang Cai He Yanan Zhou Yu Zhang Aqu Alu Jie Shi Jian Liu Furong qin Danyi Ao Xiya Huang Zimin Chen Hao Yang Yun Yang Wenhai Yu Cong Tang Junbin Wang Bai Li Qing Huang Hongbo Hu Wei Cheng Haohao Dong Jian Lei Lu Chen Xikun Zhou Jiong Li Li Yang Zhenling Wang Wei Wang Guobo Shen Jinliang Yang Zhiwei Zhao Xiangrong Song Guangwen Lu Qiangming Sun Youchun Wang Shuaiyao Lu Xiawei Wei 
supported by the National Science Foundation for Excellent Young Scholars(32122052,X.W.);National Natural Science Foundation Regional Innovation and Development(No.U19A2003,X.W.);National Natural Science Foundation of China(32300743,H.L.);the Project of the Science and Technology Department of Sichuan Province(NO.2024NSFSC1757,H.L.);National Natural Science Foundation of China Young Student Basic Research Program(323B2050,W.H.)。
The mucosal immune response plays a crucial role in the prevention of respiratory viruses.Given the risk of recurrent SARS-CoV-2 infections in the population,the rapid development of next-generation intranasal COVID-1...
关键词:NASAL IMMUNITY protective 
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