Crohn’s disease(CD)is a chronic inflammatory disorder characterized by dysregulated immune responses and significant disruption of intestinal immunity.A recent case-control study by Andreu-Ballester et al revealed de...
Objectives:Although Yes-associated protein 1(YAP1)is an important oncogene in hepatocellular carcinoma(HCC)progression,its nuclear localization prevents it from being considered a potential therapeutic target.Recently...
supported by the National Major Science and Technology Program on New Genetically Modified Organism Variety Breeding,China(Grant No.2016ZX08001-001).
Rice leaf morphology is of great significance in the breeding of an ideal plant type and high photosynthetic efficiency.A forward genetics approach was employed to locate a novel gene,NRL9(NARROW AND ROLLED LEAF 9).NR...
A deficiency ofγδT cells has been described in Crohn's disease(CD).AIM To analyze the gene expression of interleukin 7(IL-7)and its receptors in the tissues of patients with CD.METHODS We studied the peripheral bloo...
Supported by National Natural Science Foundation of China,No.82160762;Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230267;China Undergraduate Innovation and Entrepreneurship Training Program,No.S202410598060X;China Undergraduate Innovation and Entrepreneurship Training Program,No.X202410598360;Future Academic Star of Guangxi Medical University,No.WLXSZX24074.
BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on th...
supported by the National Key R&D Program of China (No.2022YFA1303600).
Chronic hepatitis B virus(HBV)infection is a leading cause of liver cirrhosis and he-patocellular carcinoma,representing a global health problem for which a functional cure is difficult to achieve.The HBV core protein...
supported by the grants from the National Natural Science Foundation of China(Nos.32070147,30670170 and 32470172 to C.L.);the MOST(No.2018YFA0507201 to C.L.),the Science and Technology Program from Forestry Administration of Guangdong(No.2024KJCX020 to C.L.);the Pingdingshan College PhD Startup Fund(No.PXY-BSQD-2024007 to R.S.).
There are three isoforms of human collagen prolyl 4-hydroxylases(C-P4Hs),each of which has been reported to play an important role in regulating the progression of a variety of human cancers.By analyzing TGCA datasets...
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LR21C070001);the National Natural Science Foundation of China(Nos.32122028,92254307,32070739,and 32100600)。
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physio...
supported by the National Institute on Aging (NIA);National Institutes of Health (NIH);Nos.K99AG065645,R00AG065645;R00AG065645-04S1 (to SK);NIH research grants,NINDS,No.R01 NS115834;NINDS/NIA,No.R01 NS115834-02S1 (to LG)。
Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-rel...
supported by the National Science Foundation for Excellent Young Scholars(32122052,X.W.);National Natural Science Foundation Regional Innovation and Development(No.U19A2003,X.W.);National Natural Science Foundation of China(32300743,H.L.);the Project of the Science and Technology Department of Sichuan Province(NO.2024NSFSC1757,H.L.);National Natural Science Foundation of China Young Student Basic Research Program(323B2050,W.H.)。
The mucosal immune response plays a crucial role in the prevention of respiratory viruses.Given the risk of recurrent SARS-CoV-2 infections in the population,the rapid development of next-generation intranasal COVID-1...