supported by the National Key Research and Development Program of China(2022YFA1103700,2020YFA0804000,2020YFA0112200,2021YFF1201005,and the STI2030-Major Projects-2021ZD0202400);the National Natural Science Foundation of China(81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863,82122024,and 82071588);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation(Z190019);Youth Innovation Promotion Association of CAS(E1CAZW0401);the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes(11000022T000000461062);the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0101,CAS-WX2021SF-0301,and CAS-WX2022SDC-XK14);Young Elite Scientists Sponsorship Program by CAST(YESS20200012);the New Cornerstone Science Foundation through the XPLORER PRIZE(2021-1045);the Excellent Young Talents Program of Capital Medical University(12300927);the Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team(BPHR202203105).
Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging.Here,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also r...