supported by the National Key Research and Development Program of China(2022YFA1103700,2020YFA0804000,2020YFA0112200,2021YFF1201005,and the STI2030-Major Projects-2021ZD0202400);the National Natural Science Foundation of China(81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863,82122024,and 82071588);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation(Z190019);Youth Innovation Promotion Association of CAS(E1CAZW0401);the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes(11000022T000000461062);the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0101,CAS-WX2021SF-0301,and CAS-WX2022SDC-XK14);Young Elite Scientists Sponsorship Program by CAST(YESS20200012);the New Cornerstone Science Foundation through the XPLORER PRIZE(2021-1045);the Excellent Young Talents Program of Capital Medical University(12300927);the Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team(BPHR202203105).
Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging.Here,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also r...
supported by grants from the National Natural Science Foundation of China(31730026,81930039,32000633);National Key Research and Development Program(2021YFC2300603),Natural Science Foundation of Shandong Province(ZR2020QH136);China Postdoctoral Science Foundation(2020M682187),and Postdoctoral Innovation Project of Shandong Province(202002012).
The adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor(RLR)signaling cascade.Lys63(K63)-linked polyubiquitination is critical for MAVS aggregation,yet the underlying mechanism and the ...