BICISTRONIC

作品数：18被引量：44H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：关菁魏丽惠马俐君更多>>
相关机构：北京医科大学人民医院中国科学院更多>>
相关期刊：《Chinese Medical Journal》《外科研究与新技术（中英文）》《Frontiers of Agricultural Science and Engineering》《中国生物学文摘》更多>>
相关基金：国家自然科学基金福建省自然科学基金更多>>
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Expression levels and stoichiometry of Hnf1β,Emx2,Pax8 and Hnf4αinfluence direct reprogramming of induced renal tubular epithelial cells
《Cell Regeneration》2024年第1期180-191,共12页Xueli Hu Jianjian Sun Meng Wan Bianhong Zhang Linhui Wang Tao P.Zhong 
Ministry of Science and Technology of the People’s Republic of China(2018YFA0800103,2018YFA0801004);National Natural Science Foundation of China(NSFC31530044,NSFC31970780,NSFC82202056).
Generation of induced renal epithelial cells(iRECs)from fibroblasts offers great opportunities for renal disease mod-eling and kidney regeneration.However,the low reprogramming efficiency of the current approach to ge...
关键词：iRECs Bicistronic retroviral cassettes Renal transcriptional factors 
Novel CD123×CD33 bicistronic chimeric antigen receptor(CAR)-T therapy has potential to reduce escape from single-target CAR-T with no more hematotoxicity被引量：1
《Cancer Communications》2023年第10期1178-1182,共5页Zhenzhen Wang Yang Lu Yu Liu Junli Mou Xiaoyu Liu Manling Chen Ying Wang Yingxi Xu Qing Rao Haiyan Xing Kejing Tang Zheng Tian Bing Wang Wei Qi Min Wang Shaowei Qiu Dongsheng Xiong Jianxiang Wang 
supported by the National Key Research and Development Program of China(2021YFC2500300);the National Natural Science Foundation of China(81830005);Haihe Laboratory of Cell Ecosystem Innova-tion Fund(HH22KYZX0032);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2020-I2M-C&T-A-019).
Dear Editor,Antigen escape is responsible for resistance[1]or disease relapse[2]from single-target chimeric antigen receptor(CAR)-T therapy.Dual-target CAR-T therapy has the potential to overcome the escape problem.Ho...
关键词：CAR acute Antigen 
Two bicistronic DNA vaccines against Vibrio anguillarum and the immune eff ects on flounder Paralichthys olivaceus
《Journal of Oceanology and Limnology》2022年第2期786-804,共19页Hanlin LI Jing XING Xiaoqian TANG Xiuzhen SHENG Heng CHI Wenbin ZHAN 
Supported by the National Natural Science Foundation of China(Nos.32173005,31730101,31672684);the National Key Research and Development Program of China(No.2018YFD0900503);the Shandong Provincial Natural Science Foundation(No.ZR2020KC025);the Fundamental Research Funds for the Central Universities(No.201822015);the Director Foundation of Functional Laboratory for Marine Fisheries Science and Food Production Processes,Qingdao National Laboratory for Marine Science and Technology(No.2018MFSD-01);the NBRPC(No.2012CB114406);the Key Research and Development Program of Shandong Province(No.2016GNC115001);the Taishan Scholar Program of Shandong Province。
Chemokines are cytokines that can promote the activation and migration of immune cells,and increase the recognition of antigen by antigen-presenting cells(APC).Previous studies showed that a DNA vaccine can induce hum...
关键词：Vibrio anguillarum outer membrane protein K bicistronic DNA vaccines CC-motif ligand 4 CC-motif ligand 19 immune response 
Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses被引量：5
《Neural Regeneration Research》2022年第1期122-129,共8页Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovyeva Aleksandr M.Aimaletdinov Albert A.Rizvanov 
funded by the subsidy allocated to Kazan Federal University for the state assignment#0671-2020-0058 in the sphere of scientific activities。
Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency ofβ-hexosaminidase A(HexA)enzyme,which results in the accumulation of GM2 gangliosides in the nervous sy...
关键词：bicistronic vector cell-mediated gene therapy GM2 gangliosidosis P2A peptide Sandhoff disease Tay-Sachs disease umbilical cord blood mononuclear cells β-hexosaminidase 
IRES-mediated cap-independent translation,a path leading to hidden proteome被引量：21
《Journal of Molecular Cell Biology》2019年第10期911-919,共9页Yun Yang Zefeng Wang 
This work is supported by the National Natural Science Foundation of China(31570823,31661143031,and 31730110 to Z.W.,91753135 and 31870814 to Y.Y.);Z.W.is also supported by the CAS Pioneer 100-Talent Program(type A).Y.Y.is also sponsored by the Youth Innovation Promotion Association CAS and Shanghai Scienee and Technology Committee Rising-Star Program(19QA1410500).
Most eukaryotic mRNAs are translated in a cap-dependent fashion;however,under stress conditions,the cap-independent translation driven by internal ribosomal entry sites(IRESs)can serve as an alternative mechanism for ...
关键词：IRES ITAF TRANSLATION BICISTRONIC system circular RNA 
Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgenic cells and transgenic mice被引量：1
《Frontiers of Agricultural Science and Engineering》2016年第1期87-96,共10页Xiaoming HU Jing GUO Chunling BAI Zhuying WEI Li GAO Tingmao HU Shorgan BOU Guangpeng LI 
supported by the National Transgenic Breeding Project (2014ZX08007-002)
In the present study, follistatin(FST) gene expression vectors with either a bicistronic gene transfer cassette alone, or a bicistron gene cassette carrying a matrix attachment region(MAR) were constructed and transfe...
关键词：safety of transgenic bicistron gene transfer body transgenic mice muscle development 
Characterization of dual enzyme resulted from bicistronic expression of two β-glucanases in porcine cells
《Journal of Integrative Agriculture》2015年第4期732-740,共9页ZHANG Xian-wei LI Zi-cong MENG Fan-ming WANG De-hua LIU De-wu HE Xiao-yan SUN Yue BAI Yin-shan WU Zhen-fang 
funded by a grant from the National Science and Technology Major Projects of China (2014ZX08006004);three grants from the Department of Science and Technology of Guangdong,China (20111090700016,2011A020102003 and 2011A020201009)
Many animal feed grains contain high β-glucan in the cell wall. Pigs do not secret β-glucanase to degrade the β-glucan in their feed. The indigestible β-glucan not only blocks the release of nutrients from the gra...
关键词：Β-GLUCANASE BICISTRONIC pig feed digestibility salivary gland cells TRANSGENIC 
Construction of a bicistronic recombinant adenoviral vector for human interleukin-10 and enhanced green fluorescent protein expression in bone marrow mesenchymal stem cells被引量：7
《Chinese Medical Journal》2012年第1期102-108,共7页LIN Jian-qing LIN Cai-zhu LIN Xian-zhong ZENG Kai GAO You-guang 
This study was supported by grants from the Natural Science Foundation of Fujian Province （No. 2008J0091 and No. 080916）.
Background Human interleukin-10 （hlL-10） is a cytokine synthesis inhibitory factor,which is involved in various immune responses.The purpose of this study was to construct an adenoviral vector carrying the hlL-10 ge...
关键词：human interleukin-10 adenoviral vector bone marrow mesenchymal stem cells 
Construction of bicistronic green fluorescent protein labeled pSELECT GFPzeo human bone morphogenetic protein 2 eukaryotic expression vector
《外科研究与新技术》2011年第2期91-91,共1页黄洪超 
Objective To construct green fluorescent protein (GFP)-labeled pSELECT-GFP zeohBMP2 eukaryotic expression vector.Methods The encoding fragment of hBMP2 gene was obtained from a recombinant plasmid pcDNA3.1/CT-hBMP2 by...
关键词：PCR GFP Construction of bicistronic green fluorescent protein labeled pSELECT GFPzeo human bone morphogenetic protein 2 eukaryotic expression vector GENE 
Construction and expression of a bicistronic vector containing human bone morphogenetic protein 2 and vascular endothelial growth factor-165 genes in vitro被引量：3
《Chinese Medical Journal》2009年第4期471-473,共3页TIAN Xiao-bin SUN Li ZHANG Yu-kun GAO Yong FU De-hao YANG Shu-hua 
It has been well documented that bone morphogenetic .proteins （BMPs）, a group of proteins belonging to the transforming growth factor-β （TGFβ） superfamily, can induce bone formation, both in vivo and in vitro. B...
关键词：bone morphogenetic protein 2 vascular endothelial growth factor-165 CO-EXPRESSION bicistronic vector 
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