RIFAMYCIN

作品数：6被引量：11H指数：1
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Characterizing Post-PKS Modifications of 16-Demethyl-rifamycin Revealed Two Dehydrogenases Diverting the Aromatization Mode of Naphthalenic Ring in Ansamycin Biosynthesis
《Chinese Journal of Chemistry》2022年第13期1553-1558,共6页Ting-Yan Han Kai Zhang Gong-Li Tang Qiang Zhou 
We thank the financial support from the National Natural Science Foundation of China(22137009 and 21907067).
The anti-tuberculous rifamycins belong to naphthalenic ansamycin based on the structure of aromatic chromophore.Herein,we explored the post-polyketide synthase(PkS)modifications in the biosynthesis of 16-demethyl-rifa...
关键词：Ansamycin Natural products BIOSYNTHESIS DEHYDROGENATION AROMATIZATION 
美国FDA批准Aemcolo(rifamycin)治疗旅行者腹泻
《广东药科大学学报》2018年第6期797-797,共1页夏训明(编译) 
美国FDA于2018年11月16日批准Aemcolo(rifamycin,利福霉素,CAS登记号:6998-60-3)用于成人治疗旅行者腹泻(Travelers diarrhea),适用于因非侵袭性大肠杆菌菌株 (Escherichia coli,E. coli)引起且没有伴发发热和便血的旅行者腹泻。旅行者...
关键词：美国FDA 旅行者 FDA批准 腹泻 治疗 侵袭性大肠杆菌 感染性疾病 利福霉素 
The Use of the PCR-Based Dot-Blot Hybridization Assay to Detect Resistance Markers to Rifampicin and Streptomycin in Mycobacterium tuberculosis Isolates from the SW Region of Cameroon
《Journal of Tuberculosis Research》2016年第2期72-79,共8页Irene Ane-Anyangwe Wilfred Fon Mbacham Henry Dilonga Meriki Teyim Pride Theresa Nkuo-Akenji Veronique Mbeng Penlap Leopold Djomkam Tietcheu Damian Nota Anong Akindeh Mbuh Nji Vincent P. K. Titanji 
Drug sensitivity testing to establish resistance to TB drugs takes many months to arrive at. Public health physicians have difficulties with such an approach due to long wait periods and cannot use it to establish com...
关键词：PCR-Based DOT-Blot Analysis RIFAMYCIN STREPTOMYCIN SW Region 
Production and purification of a bioactive substance against multi-drug resistant human pathogens from the marine-sponge-derived Salinispora sp.
《Asian Pacific Journal of Tropical Biomedicine》2014年第10期825-831,共7页Satyendra Singh Pritesh Prasad Ramesh Subramani William Aalbersberg 
Support from the U.S.National Institutes of Health's International Cooperative Biodiversity Groups Program(Grant NO.NIH ICBG U01-TW007401)
Objective:To isolate,purify,characterize,elucidate structure and evaluate bioactive compounds from the sponge-derived Salinispora sp.FS-0034.Methods:The symbiotic actinomycete strain FS-0034 with an interesting bioact...
关键词：MARINE ACTINOMYCETES Sponge-derived Salinispora Multi-drug resistant ANTIBACTERIAL RIFAMYCIN 
Two genes, rill5 and rill6, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B被引量：1
《Acta Biochimica et Biophysica Sinica》2011年第12期948-956,共9页Hua Yuan Wei Zhao Yi Zhong Jin Wang Zhongjun Qin Xiaoming Ding Guo-Ping Zhao 
Amycolatopsis mediterranei produces an important anti- biotic rifamycin, the biosynthesis of which involves many unusual modifications. Previous work suggested a puta- tive P450 enzyme encoded by rill6 within the rifa...
关键词：Amycolatopsis mediterranei RIFAMYCIN P450 TRANSKETOLASE 
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism被引量：11
《Cell Research》2010年第10期1096-1108,共13页Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao 
This paper is dedicated to the late Professor JS Chiao, who initiated the research in China for rifamycin production employing A. mediterranei more than 30 years ago and who continued the endeavor to resolve the mechanism of the ＇nitrate stimulating effect＇ up to the last breath of his life. This work was supported by the National Natural Science Foundation of China （30830002）, the National High Technology Research and Development Program of China （2007AA021301, 2007AA021503）, and the Research Unit Fund of Li Ka Shing Institute of Health Sciences （7103506）.
Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimyco- bacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strai...
关键词：GENOME Amycolatopsis mediterranei RIFAMYCIN PHYLOGENY P450 METABOLISM 
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