TRANSKETOLASE

作品数：6被引量：16H指数：2
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相关领域：医药卫生更多>>
相关作者：赵静钟春玖更多>>
相关机构：复旦大学上海医学院复旦大学更多>>
相关期刊：《World Journal of Diabetes》《Genes & Diseases》《Current Medical Science》《Neuroscience Bulletin》更多>>
相关基金：国家自然科学基金更多>>
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Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis
《Genes & Diseases》2025年第3期382-396,共15页Kai Huang Linyu Yang Yue Ma Lijian Cao Suwen Li Zhenzhen Zhao Jianwu Zhou Shan Wang 
supported in part by research grants from the Key Project of the National Key R&D Plan“Research on Prevention and Control of Major Chronic Non-Communicable Diseases”(China);the Ministry of Science and Technology of the People’s Republic of China,and the National Key R&D Program of China(No.2018YFC1313000,2018YFC1313004).
The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM)and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiti...
关键词：Bone marrow metastasis Bone metastasis IMMUNOTHERAPY Multi-omics NEUROBLASTOMA Transketolase(TKT) 
B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets被引量：2
《Current Medical Science》2021年第5期847-856,共10页Ying ZHENG Zhi-yong CHEN Wen-jun MA Qiu-zhen WANG Hui LIANG Ai-guo MA 
supported by a grant from Medical Scientific Research Foundation of Guangdong Province,China(No.A2018282).
Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and activity.Methods:To test this,we ...
关键词：B vitamins OBESITY conditioned taste aversion Morris water maze COGNITION TRANSKETOLASE 
Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?被引量：3
《World Journal of Diabetes》2014年第3期288-295,共8页Luká? Pácal Katarína Kuricová Katerina Kaňková 
Supported by The Grant from the Ministry of Health of Czech Republic,No.NT13198
Growing prevalence of diabetes(type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic mi...
关键词：DIABETES THIAMINE Vitamin B1 TRANSKETOLASE BENFOTIAMINE Hyperglycemia NEPHROPATHY Metabolic syndrome Cardiovascular disease Chronic kidney disease 
Two genes, rill5 and rill6, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B被引量：1
《Acta Biochimica et Biophysica Sinica》2011年第12期948-956,共9页Hua Yuan Wei Zhao Yi Zhong Jin Wang Zhongjun Qin Xiaoming Ding Guo-Ping Zhao 
Amycolatopsis mediterranei produces an important anti- biotic rifamycin, the biosynthesis of which involves many unusual modifications. Previous work suggested a puta- tive P450 enzyme encoded by rill6 within the rifa...
关键词：Amycolatopsis mediterranei RIFAMYCIN P450 TRANSKETOLASE 
Identification of potential P. falciparum transketolase inhibitors: pharmacophore design, in silico screening and docking studies
《Journal of Biophysical Chemistry》2010年第2期96-104,共9页Shweta Joshi Alok Ranjan Singh Uzma Saqib Prakash Chandra Misra Mohammad Imran Siddiqi Jitendra Kumar Saxena 
Transketolase, the most critical enzyme of the non-oxidative branch of the pentose phosphate pathway, has been reported as a novel target in Plasmodium falciparum as it has least homology with the human host. Homology...
关键词：PLASMODIUM FALCIPARUM TRANSKETOLASE 
A review on research progress of transketolase被引量：10
《Neuroscience Bulletin》2009年第2期94-99,共6页赵静 钟春玖 
the National Natural Science Foundation of China (No. 30870871).
Transketolase （TK）, a thiamine diphosphate （ThDP）-dependent enzyme, catalyzes several key reactions of nonoxidative branch of pentose phosphate pathway. TK is a homodimer with two active sites that locate at the i...
关键词：TRANSKETOLASE Pentose phosphate pathway neurodegenerative disease  TKTL-1 gene 
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