CHECKPOINT

作品数:720被引量:1395H指数:15
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相关领域:医药卫生自动化与计算机技术更多>>
相关作者:段红刘穆进张彩田志刚景年财更多>>
相关机构:上海大学华中科技大学国防科学技术大学CheckPoint软件技术有限公司更多>>
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相关基金:国家自然科学基金中国博士后科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Efficacy and safety of immune checkpoint therapy in hepatocellular carcinoma: meta-analysis
《Hepatoma Research》2019年第6期7-15,共9页Weina Tang Long-Teng Ma Yang Deng Wei Wang Hong-Wei Zhang 
This work was supported by National Key Basic Research Program of China(No.2015CB554000).
Aim:Immune checkpoint inhibitors(ICIs)are proven to be an effective way to treat the disease of hematologic malignancies.But there is still plenty of uncertainty about the effectiveness of ICIs on hepatocellular carci...
关键词:HEPATOCELLULAR immune-checkpoint inhibitor CLAT-4 PD1/PD-L1 
Challenges of NK cell-based immunotherapy in the new era被引量:13
《Frontiers of Medicine》2018年第4期440-450,共11页Fang Fang Weihua Xiao Zhigang Tian 
This work was supported by the National Natural Science Foundation of China (Nos. 81788101, 91542000, 81671558, and 31571440); the Ministry of Science and Technology of China (No. 2016YFC1303503) and Chinese Academy of Sciences (Nos. XDA12020312, XDPB030301, and XDPB030303).
Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including...
关键词:natural killer cells IMMUNOTHERAPY adoptive transfer genetic modification immune checkpoint inhibitor 
NK细胞受体群谱偏移与肿瘤免疫逃逸及逆转被引量:8
《中国免疫学杂志》2016年第5期609-614,共6页张彩 田志刚 
国家重点基础研究发展计划(973)项目(2013CB944901);国家自然科学基金项目(81273220;81472646;91442114)资助
NK细胞功能的发挥取决于其表面活化受体和抑制性受体识别靶细胞表面相应配体后所传递信号的平衡状态。肿瘤在发生发展的过程中进化出许多机制,调控NK细胞活化受体和抑制性受体的表达及肿瘤细胞NK细胞识别的配体表达的平衡状态,通常表现...
关键词:NK细胞 NK细胞受体 肿瘤免疫逃逸 免疫治疗 Checkpoint阻断疗法 CAR-NK 
BRCA1 and its phosphorylation involved in caffeine-inhibitable event upstream of G2 checkpoint被引量:2
《Science China(Physics,Mechanics & Astronomy)》2010年第7期1281-1285,共5页LI Ning ZHANG Hong WANG YanLing HAO JiFang 
supported by the National Basic Research Program of China (Grant No. 2010CB834202);the National Natural Science Foundation of China (Grant Nos. 10835011and 10805064);the Scientific Technology Research Projects of Gansu Province (Grant Nos. 0806RJYA020 and 099RJYA015);Western Talent Program of Chinese Academy of Sciences (Grant No. 0860260XBO)
Caffeine,which specifically inhibits ATM/ATR kinases,efficiently abrogates the ionizing radiation(IR)-induced G2 arrest and increases the sensitivity of various tumor cells to IR.Mechanisms for the effect of caffeine ...
关键词:BRCA1 PHOSPHORYLATION ionizing irradiation CAFFEINE G2 checkpoint 
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