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作品数：733被引量：1407H指数：15
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Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma
《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang 
supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).
Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...
关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping 
Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma
《Genes & Diseases》2025年第3期265-277,共13页Silu Ding Yingying Hao Yue Qi Heng Wei Jin Zhang Hui Li 
Endometrial carcinoma(EC)is a prevalent gynecological cancer,and its interaction with the immune system is pivotal in cancer progression.This comprehensive review explores the molecular mechanisms involved in the regu...
关键词：Clinical implication Endometrial carcinoma Immune checkpoint pathways Immune evasion strategies Tumor-infiltrating immune cells 
Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer
《Oncology Research》2025年第5期1069-1089,共21页JINGDAN QUAN ZIXIN WAN WEI WU XINYUAN CAO JIAYUAN QIU XIAOYE LIU ZHIWEI ZHANG 
funded by the National Key Research and Development Project,grant number 2021YFE0192100;Natural Science Foundation of Hunan Province,grant numbers 2021JJ30694,2023JJ30529;Innovation and Entrepreneurship Training Program for College Students in Hunan Province,grant number S202210555254;Key Projects of Hunan Provincial Education Department,grant number 21A0285;Natural Science Foundation of Hunan Provincial and Municipal Co-Funding,grant number 2022JJ50029;Key Projects of Shaoyang Science and Technology Bureau,grant number 2021GZ031;Innovation and Entrepreneurship Training Program for College Students of the University of South China,grant numbers D202405212006326156,D202405210948392932,D202405211329047648,D202405221955420827.
One of the most prevalent malignant tumors worldwide,stomach cancer still has a high incidence and fatality rate in China,and the number of young people developing early-onset gastric cancer is steadily increasing.The...
关键词：Gastric cancer Biomarkers Immune checkpoint molecules Diagnosis MicroRNA CircRNA LncRNA PIRNA 
Vitiligo-like rash in a patient with lung cancer caused by sintilimab: A case report
《World Journal of Clinical Cases》2025年第14期32-37,共6页Xiao-Ming Mao Wei-Hua Wang 
BACKGROUND This article discusses a case involving a 63-year-old man with non-small cell lung cancer,who was treated with a combination of chemotherapy and immunothe-rapy.The patient was treated with five cycles of ch...
关键词：Lung cancer VITILIGO Immune checkpoint inhibitor Sintilimab Case report 
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization
《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu 
supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。
Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...
关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors 
The effect of concomitant drugs on oncological outcomes in patients treated with immunotherapy for metastatic urothelial carcinoma:a narrative review
《Oncology Research》2025年第4期741-757,共17页MICHELE MAFFEZZOLI GIULIA CLAIRE GIUDICE GIACOMO IOVANE MARTINA MANINI ELENA RAPACCHI GIUSEPPE CARUSO NICOLA SIMONI STEFANIA FERRETTI STEFANO PULIATTI DAVIDE CAMPOBASSO SEBASTIANO BUTI 
Background:immune checkpoint inhibitors(ICIs)have revolutionized the treatment of metastatic urothelial carcinoma(mUC),significantly improving survival outcomes.However,a subset of patients do not respond to ICIs,prom...
关键词：Immune checkpoint inhibitors(ICIs) Urothelial carcinoma(UC) Concomitant drugs Proton pump inhibitors Antibiotics(Abs) Angiotensinconverting enzyme inhibitors(ACEIs) 
Immune checkpoint inhibitors plus anti-angiogenesis in patients with resected high-risk hepatitis B virus-associated hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第4期116-130,共15页Jian-Lin Lu Yuan Cheng Zi-Ling Xu Gui-Xiang Qian Ming-Tong Wei Wei-Dong Jia 
Supported by the Key Research and Development Projects of Anhui Province,No.202104j07020048;National Key Research and Development Program of China,No.2022YFA1304500.
BACKGROUND Currently,there is a lack of effective adjuvant therapies for patients at high-risk of recurrent hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC)after radical resection.Given the efficacy of a...
关键词：Hepatocellular carcinoma Hepatitis B virus Postoperative adjuvant therapy Immune checkpoint inhibitors ANTIANGIOGENESIS 
Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity
《Food Science and Human Wellness》2025年第2期651-661,共11页Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang 
supported by Natural Science Foundation of Guangdong Province,China(2022A1515011575);National Natural Science Foundation of China,China(81873154);President Foundation of Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,China(1202103010)。
Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSC...
关键词：Lycii Radicis Cortex Non-small cell lung cancer PD-L1 Immune checkpoint 
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy
《Acta Pharmacologica Sinica》2025年第4期1058-1067,共10页Ming-ming Zheng Jia-yi Li Hong-jie Guo Jie Zhang Long-sheng Wang Ke-fan Jiang Hong-hai Wu Qiao-jun He Ling Ding Bo Yang 
supported by the National Natural Science Foundation of China(No.82330114 to QJH,and No.82273949 to LD).
Tumor cells are characterized by rapid proliferation.In order to provide purines for DNA and RNA synthesis,inosine 5’-monophosphate dehydrogenase(IMPDH),a key enzyme in the de novo guanosine biosynthesis,is highly ex...
关键词：non-small cell lung IMPDH inhibitors PD-L1 mRNA stability HUR immune checkpoint blockade 
Combining immune checkpoint inhibitors with standard treatment regimens in advanced human epidermal growth factor receptor-2 positive gastric cancer patients
《World Journal of Gastrointestinal Oncology》2025年第4期243-253,共11页Sheng-Hu Zhang Wan Li Xi-Yan Chen Le-Le Nie 
This study was approved by the ethics committee of the First People’s Hospital of Fuzhou City(No.FZ202103).
BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide,with its incidence and mortality rates ranking among the highest in gastrointestinal cancers.The overexpression or gene amplification of h...
关键词：ADVANCED Human epidermal growth factor receptor 2-positive Gastric cancer Standard treatment regimen Immune checkpoint inhibitors Efficacy Safety Prognosis Influencing factors 
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