Streptococcus pneumoniae is a known notorious cause of invasive pneumococcal diseases as well as asymptomatic host carriage. Efforts have been made to curb this infectious organism through various vaccine strategies. ...
CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-049)
Background:Influenza and pneumococcal vaccination are a priority in patients with chronic obstructive pulmonary disease(COPD).However,limited information is available on vaccination coverage among patients with acute ...
supported by a grant from Beijing Municipal Natural Science Foundation [L212011];National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention [131031102000210003&102393230020020000002]。
Objective To establish and modify quantitative real-time polymerase chain reaction(qPCR)-based serotyping assays to distinguish 97 pneumococcal serotypes.Methods A database of capsular polysaccharide(cps)loci sequence...
National Key R&D Program of China(2017YFC1309304).
Summary What is already known on this topic?Chronic obstructive pulmonary disease(COPD)exacerbations increase household economic burden,but there is limited evidence from prospective cohort studies in China about the ...
supported by Fundamental Research Grant Scheme(FRGS/1/2020/SKK0/UPM/02/10)of the Ministry of Higher Education Malaysia.
Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and genotype.Methods:In total,42 clinical isolates were colle...
the National Center for Protein Sciences at Peking University for assistance with Amersham Imager;and Guilan Li for help with cDNA library.The work was supported by the National Key Research and Development Program of China(2017YFA0505200 and 2016YFC0906000 to J.X.;2019YFA0508904 to N.G.);the National Science Foundation of China(31570735 and 31822014 to J.X.;31725007 and 31630087 to N.G.);the Qidong-SLS Innovation Fund to J.X.and N.G.;and the Clinical Medicine Plus X Project of Peking University to J.X.
Secretory Immunoglobulin A(SIgA)is the most abundant antibody at the mucosal surface.It possesses two additional subunits besides IgA:the joining chain(J-chain)and secretory component(SC).SC is the ectodomain of the p...
This study investigates poly(vinyl alcohol) (PVA) membranes as controlled release micro-matrices, which can be useful in therapeutic applications for optimizing the administration of drugs. Currently, the use of hydro...
BACKGROUND Asplenia,the lack of a spleen,can be congenital and increases susceptibility to severe infections caused by encapsulated bacteria,such as Streptococcus pneumoniae(S.pneumoniae).We report two cases of severe...
AIM To evaluate the uptake of a mandatory meningococcal, a highly recommended influenza, and an optional pneumococcal vaccine, and to explore the key factors affecting vaccination rate among health care workers(HCWs) ...
Streptococcus pneumoniae is a primary cause of illness and death among children younger than 5 years in China. The heptavalent pneumococcal conjugate vaccine (PCV7) was the only conjugated vaccine (PCV) available in C...