RADIOLABELING

作品数：22被引量：16H指数：3
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Radiolabeling of lacosamide using highly purified rhenium-188 as a prospective brain theranostic agent被引量：1
《Nuclear Science and Techniques》2020年第10期105-114,共10页H.A.El-Sabagh M.I.Aydia A.M.Amin K.M.El-Azony 
Rhenium-188 is prospectively effective for both diagnosis and radiotherapy as it appropriately emits gamma rays and beta particles.Lacosamide(LCM)is a newly approved antiepileptic medication for focal drug-resistant e...
关键词：LACOSAMIDE 188Re 188W/188Re generator RADIOLABELING 
Radiolabeling, docking studies, in silico ADME and biological evaluation of serotonin with 125I for 5-HTRs imaging
《Nuclear Science and Techniques》2020年第8期64-71,共8页Dina M.El-Sharawy Marwa S.El Refaye H.Hussien Asmaa M.AboulMagd 
Serotonin is one of the significant signaling molecules used by several neural systems in the gut and brain. This study aimed to develop a novel and potent tracer for targeting, detecting, and imaging serotonin recept...
关键词：SEROTONIN Electrophilic substitution Molecular modeling 5HTRs 
Expression and radiolabeling of Cas9 protein
《Nuclear Science and Techniques》2017年第1期74-79,共6页Qing-Long Yan Hua-Ting Kong Kai Xia Yu Zhang Ali Aladlbahi Ji-Ye Shi Li-Hua Wang Chun-Hai Fan Yun Zhao Ying Zhu 
supported by the National Key Research and Development Program(No.2016YFA0400902);the Ministry of Science and Technology of China(Nos.2012CB825805,2012CB932600);the National Natural Science Foundation of China(Nos.11675251 and 11275251);Shanghai Rising-Star Program(No.14QA1404400);Distinguished Scientist Fellowship Program of King Saud University;the Youth Innovation Promotion Association of CAS(No.2016236)
As a robust platform for genome editing,CRISPR/Cas9 is currently being explored for engineering biology or therapeutics,yet means for quantitative detection of Cas9 proteins remain to be fully realized.Here,we express...
关键词：Cas9 RADIOLABELING 125I LABELING YIELD STABILITY 
Synthesis, radiolabeling and biological evaluation of butene amine oxime containing nitrotriazole as a tumor hypoxia marker
《Nuclear Science and Techniques》2016年第2期35-43,共9页Qiang Zhang Tai-Wei Chu 
supported by the National Natural Science Foundation of China (Grant Nos. 21371017 and 81371592)
^(99m)Tc-BnAO, as a nonnitroaromatic hypoxia marker, is the subject of intensive research in recent years. In this study, a butene amine oxime–nitrotriazole(Bn AO–NT)was synthesized and radiolabeled with ^(99m)Tc in...
关键词：细胞缺氧 肿瘤模型 生物学评价 标记 合成 胺肟 丁烯 S180 
Study on radiolabeling of 1,2,3-triazole analogs with fac-[^(188)Re(CO)_3 (H_2O)_3 ]^+ via click chemistry
《Nuclear Science and Techniques》2013年第3期27-30,共4页WANG Cheng YIN Jilin ZHOU Wei ZHANG Lan ZHOU Zheng 
Supported by National Natural Science Foundation of China(No.10875163);Natural Science Foundation of Guangdong Province(Nos.2009B030108036 and S2012010010685)
Click chemistry was used to study on radiolabeling of 1,2,3-triazole analogs with fac-[188 Re(CO) 3 (H 2 O) 3]+ . CuSO 4 /L-sodium ascorbate was chosen as the catalyst system, three terminal alkynes were conjugated wi...
关键词：化学研究 三唑类 类似物 CO 生物活性评价 生物活性分子 化学产率 催化剂体系 
Radiolabeling and evaluation of ^(188)Re-RGD as an agent for α_vβ_3 receptor expression
《Nuclear Science and Techniques》2012年第1期47-51,共5页Yufei MA Junfeng YU Cheng WANG Hua SHEN Hua WU 
Supported by Nature Science Foundation of China under Contract NO.81101066
Integrin αvβ3,a cell adhesion molecule,plays a key role in angiogenesis and tumor cell metastasis and is therefore an important target for new therapeutic and diagnostic strategies.Since RGD bind to αvβ3 particula...
关键词：放射性标记 AV RGD序列 评价 代理 受体 细胞粘附分子 肿瘤细胞 
Synthesis, radiolabeling and animal studies of [^(131)I]MPPI: A 5-HTB_(1A) imaging agent
《Nuclear Science and Techniques》2006年第1期43-47,共5页SUN Bai-Shan LU Chun-Xiong ZOU Mei-Fen JIANG Quan-Fu WANG Song-Pei LI Xiao-Min CHEN Zheng-Ping ZHU Jun-Qing WU Chun-Ying 
Supported by grants from National Natural Science Foundation of China (30470496);"135" Medicinal Momentous Project of Jiangsu Province (RC2002068);Jiangsu Natural Science Foundation (BK2004423);Department of Personnel, Jiangsu Province (2003-07).
The synthesis and biological evaluation of serotonin (5-HTB1AB) imaging agent [P131PI]- 4-iodo-N-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]-ethyl}-N-pridin-2-yl-benzamide ([P131PI]MPPI ) are reported. The chemical struct...
关键词：动物研究 放射性同位素元素示踪 成像 生物评估 
Radiolabeling of N-Succinimidyl-3-[(125)~I]iodobenzoate intermediate被引量：1
《Nuclear Science and Techniques》2004年第1期43-45,共3页WANGLi-Hua WANGYong-Xian YINDuan-Zhi LIJun-Ling 
Organostannanes were important precursors which was easy to radioiodinate. N-Succinimidyl-3- (tri-n-butylstannyl) benzoate (STB) was radiolabeled using Iodogen to get radioactive N-Succinimidyl-3-iodobenzo- ate (S125I...
关键词：放射性同位素示踪 STB 稳定性 放射化学 
A study on indirect radiolabeling of IgG with carrier free ^(188)Re
《Nuclear Science and Techniques》2003年第2期131-134,共4页ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, YIN Duan-Zhi (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) 
Supported partially by Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences(KJCX1-SW-08)
188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabeling of the ...
关键词：^188RE 铼 单克隆抗体 放射免疫性疗法 
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