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相关机构：福建中医药大学上海交通大学更多>>
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Splicing defect of StDRO2 intron 1 promotes potato root growth by disturbing auxin transport to adapt to drought stress
《Horticultural Plant Journal》2025年第2期706-720,共15页Jianping Zhao Baolin Yao Ziai Peng Xinyue Yang Kuixiu Li Xiaoyan Zhang Haiyan Zhu Xuan Zhou Meixian Wang Lihui Jiang Xie He Yan Liang Xiaoping Zhan Xiaoran Wang Yuliang Dai Yanfen Yang Ao Yang Man Dong Suni Shi Man Lu Yi Zhao Mingyun Shen Liwei Guo Changning Liu Hongji Zhang Decai Yu Yunlong Du 
supported by grants from the National Natural Science Foundation of China(Grant Nos.32260085,31860064,31660501,31970609,32260718 and 31901870);the Key Projects of the Applied Basic Research Plan of Yunnan Province(Grant No.202301AS070082);the Start-up fund from Xishuangbanna Tropical Botanical Garden,the‘Top Talents Program in Science and Technology’from Yunnan Province,the Major Science and Technology Project in Yunnan Province(Grant Nos.202102AE090042 and 202202AE090036);the Young and Middle-Aged Academic and Technical Leaders Reserve Talent Program in Yunnan Province(Grant No.202205AC160076);China Postdoctoral Science Foundation(Grant No.2019M653849XB);the High-level Talents Introduction Plan of Yunnan Province-Young Talents Special Project。
The formation of root system architecture(RSA)plays a crucial role in plant growth.OsDRO1 is known to have a function in controlling RSA in rice,however,the role of potato StDRO2,a homolog of rice OsDRO1,in root growt...
关键词：POTATO Root system architecture StDRO2 Drought stress Auxin SPLICING MicroRNA 
LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis
《World Journal of Gastroenterology》2025年第16期49-65,共17页Qing Dai Tian-Yin Qu Jin-Lan Yang Jing Leng Lin Fang Qian-Qian Zhu Ke-Bi Wu Jie Wu Jing-Jing Ma Huang-Fei Yu 
Supported by the National Natural Science Foundation of China,No.81960506;Science and Technology Fund Project of Guizhou Provincial Health Commission,No.gzwkj2022-299;Key Projects of Zunyi Science and Technology Fund,No.zunshikeheHZzi(2023)24 and No.zunshikeheHZzi(2024)9.
BACKGROUND Radiotherapy is widely employed in colorectal cancer(CRC)treatment,but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure a...
关键词：Colorectal cancer LncRNA FTX Solute carrier family 7 member 11 Ferroptosis Redox RADIORESISTANCE 
The influence of the disturbing effect of roadways through faults on the faults' stability and slip characteristics
《Deep Underground Science and Engineering》2024年第4期399-412,共14页Shuaifeng Lu Andrew Chan Xiaolin Wang Shanyong Wang Zhijun Wan Jingyi Cheng 
Australian Research Council,Grant/Award Number:DP210100437;National Natural Science Foundation of China,Grant/Award Number:52274102;Graduate Research and Innovation Projects of Jiangsu Province,Grant/Award Number:KYCX21_2335。
In order to mitigate the risk of geological disasters induced by fault activation when roadways intersect reverse faults in coal mining,this paper uses a combination of mechanical models with PFC2D software.A mechanic...
关键词：excavation speed fault stability loading and unloading test roadway crossing faults 
Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells
《Acta Pharmaceutica Sinica B》2024年第8期3680-3696,共17页Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su Yahui Wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo 
supported by the National Science and Technology Major Project of China(2023YFB3810004);the National Natural Science Foundation of China(32271445,52103175,32271382,32101145);the National Key Research and Development Program of China(2022YFC2009900);Department of Science and Technology of Sichuan Province(24NSFJQ0167,China);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21013,China);Post-Doctor Research Project,West China Hospital,Sichuan University(2021HXBH055,2021HXBH057,China);China Postdoctoral Science Foundation(2021M692314).
Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune cells.Herein,we constructed a PEGylated dendritic ep...
关键词：Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution 
IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbingα-ketoglutarate-related metabolism and epigenetic modification
《Life Metabolism》2024年第2期24-37,共14页Yuanlin Zhao Ying Yang Risheng Yang Chao Sun Xing Gao Xiwen Gu Yuan Yuan Yating Nie Shenhui Xu Ruili Han Lijun Zhang Jing Li Peizhen Hu Yingmei Wang Huangtao Chen Xiangmei Cao Jing Wu Zhe Wang Yu Gu Jing Ye 
supported by funds from the National Key Research and Development Program of China(2022YFA0806501);the National Natural Science Foundation of China(81972342 to J.Y.,82173120 to Y.G.,and 82070298 to L.Z.);the Natural Science Basic Research Plan in ShaanxiProvince(2020JZ-29 to J.Y.).
Isocitrate dehydrogenase(IDH)mutations frequently occur in lower-grade gliomas and secondary glioblastomas.Mutant IDHs exhibit a gain-of-function activity,leading to the production of D-2-hydroxyglutarate(D-2HG)by red...
关键词：Α-KETOGLUTARATE IDH1 mutation OGDH L-GLUTAMINE gliomas 
From Environmental Toxicants to Antibacterial Agents:BPA Analogues Selectively Inhibit the Growth of Gram-Positive Bacteria by Disturbing Biosynthesis of the Cell Wall
《Environment & Health》2023年第4期291-299,共9页Huiming Cao Zhunjie Li Bolei Chen Jing Wang Zhen Zhou Zhi Li Yun Qian Yong Liang 
supported by grants from the National Key Research and Development Program of China(2020YFA0907500);the National Natural Science Foundation of China(22193051,21277062,21806058);the Excellent Discipline Cultivation Project by JHUN(2023XKZ029);the PLA Logistics Research Project of China(2023).
Remarkable antibacterial activity of BPA analogues especially for tetrabromobi-sphenol A against Staphylococcus aureus 25923(Sa25923)and methicillin-resistant Staphylococcus aureus(MRSA)has been reported in our previo...
关键词：Environmental toxicants Antibacterial agents BPA analogues Lipoteichoic acid Virtual screening Machine learning 
Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics
《Bioactive Materials》2023年第11期50-71,共22页Xueli Xu Shanbin Xu Jipeng Wan Diqing Wang Xinlong Pang Yuan Gao Nengyi Ni Dawei Chen Xiao Sun 
the National Natural Science Foundation of China(22104073);the Natural Science Foundation of Shandong(ZR2021QA100,ZR2021QB119,2022HWYQ-079);the Youth Innovation Science and Technology Program of Shandong Provincial Universities(2021KJ100).
Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor cells.In clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by...
关键词：NANOMEDICINE Disturbing cytoskeleton Migration inhibition Tumor therapy 
Cinnamaldehyde inactivates Listeria monocytogenes at a low temperature in ground pork by disturbing the expression of stress regulatory genes
《Food Bioscience》2023年第1期472-482,共11页Peng Guan Xiaojie Wang Zijie Dong Miao Song Hongshuai Zhu Biao Suo 
funded by the National Natural Science Foundation of China(32272441);the Natural Science Foundation of Henan Province(222300420455);the Program for Science&Technology Innovation Talents in Universities of Henan Province(22HASTIT034;Department of Human Resources and Social Security of Henan Province。
Listeria monocytogenes is a cold tolerant foodborne pathogen that frequently detected in ground pork stored at low temperature.The study firstly evaluated the inhibitory effect of cinnamaldehyde on Listeria monocytoge...
关键词：Listeria monocytogenes CINNAMALDEHYDE Weibull model Real-time quantitative PCR Molecular docking 
Chromosome 5P of Agropyron cristatum induces chromosomal translocation by disturbing homologous chromosome pairing in a common wheat background
《The Crop Journal》2023年第1期228-237,共10页Haiming Han Xinyuan Ma Zhen Wang Kai Qi Wenjing Yang Weihua Liu Jinpeng Zhang Shenghui Zhou Yuqing Lu Xinming Yang Xiuquan Li Lihui Li 
financially supported by the National Key Research and Development Program of China (2021YFD1200605);the National Natural Science Foundation of China (32171961)。
Wide hybridization is a strategy for broadening the genetic basis of wheat. Because an efficient method for inducing wheat–alien chromosome translocations will allow producing useful germplasm, it is desirable to dis...
关键词：Agropyron cristatum WHEAT Chromosome 5P TRANSLOCATION Chromosome pairing 
The cotton mitochondrial chimeric gene orf610a causes male sterility by disturbing the dynamic balance of ATP synthesis and ROS burst被引量：4
《The Crop Journal》2022年第6期1683-1694,共12页Yongjie Zhang Yang Han Meng Zhang Xuexian Zhang Liping Guo Tingxiang Qi Yongqi Li Juanjuan Feng Hailin Wang Huini Tang Xiuqin Qiao Liangliang Chen Xiatong Song Chaozhu Xing Jianyong Wu 
supported by funds from the National Natural Science Foundation of China(31871679);the Tianshan Youth Program(2018Q010);the Central Public-interest Scientific Institution Basal Research Fund(1610162021015)。
Plant cytoplasmic male sterility(CMS)is maternally inherited and often manifested as aborted pollen development,but the molecular basis of abortion remains to be identified.To facilitate an investigation of CMS in cot...
关键词：Cytoplasmic male sterility Mitochondrial genome Chimeric gene Reactive oxygen species ATP 
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