The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute iymphoblastic leukemia in infants. Although it is well established that MLL-AF4 arises prenatally during human development, its effects on he...
While it is clear that human pluripotent stem cells (hPSCs) can differentiate to generate a panoply of various cell types, it is unknown how closely in vitro development mirrors that which occurs in vivo. To determi...