supported by the National Natural Science Foundation of China(Nos.32070709,32270771,and U21A20197);the National Key Research and Development Program of China(Nos.2019YFA0802202);the Higher Education Discipline Innovation Project(also known as the111 Project)(Nos.B13026).
Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter cells.Midbody,a protein-dense organelle that forms at the intercellular bridge,is indispensable for succe...
GO, CG and PG designed the project and analyzed the data; GO performed most experiments and prepared the figures; CG performed experiments, prepared the figures and movies; GO and PG wrote the manuscript. We thank Virginie Hachet and Fernando R Balestra for useful comments on the manuscript, as well as Michael Glotzer for the gift of ZEN-4 antibodies. We also thank Olivier Burri and Romain Guiet from the Bioimaging and Optics Platform (BIOP) at EPFL for their help with elaboration of movies. This work was supported by a grant to GO and PG from the Sino Swiss Science and Technology Cooperation (SSTC_ EG09_092011), and grants from the National Basic Research Program (2012CB945002 and 2013CB945600) and the National Natural Science Foundation of China (31222035, 31190063 and 31171295).
Dear Editor, The midbody is a structure formed within the inter- cellular bridge towards the end of cytokinesis [ 1 ]. Microtubules within this bridge are then severed on one side of the midbody during abscission, th...
This work was supported by National Natural Science Foundation of China (30671070 and 30771107), Ministry of Science and Technology of China (2007CB914500), Ministry of Education of China (NCET-06-0530), and Natural Science Foundation of Zhejiang Province, China (R205291, Y206103, and 2007R10G2010103).
Cytokinesis is the process by which a single cell divides into two physically distinct daughter cells; however, the molecular details of this fundamental process remain largely unknown . In animal cells, cytokinesis u...
The dynamic distribution of phosphorylated Histone H3 on Ser10 (phospho-H3) in cells was investigated to determineits function during mitosis. Human breast adenocarcinoma cells MCF-7, and Chinese hamster cells CHO wer...