BAICALEIN

作品数：71被引量：390H指数：11
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相关领域：医药卫生更多>>
相关作者：张黎胡燕华王琼李惠勉杨琳更多>>
相关机构：中国药科大学华中科技大学郑州大学第二附属医院北京大学更多>>
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相关基金：国家自然科学基金河南省科技攻关计划国家杰出青年科学基金广东省自然科学基金更多>>
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Baicalein:A potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
《Journal of Pharmaceutical Analysis》2024年第8期1189-1204,共16页Na Liu Xin Cui Wenhui Yan Tingli Guo Zhuanzhuan Wang Xiaotong Wei Yuzhuo Sun Jieyun Liu Cheng Xian Weina Ma Lina Chen 
funded by the Fundamental Research Funds for the Central Universities(Grant No.:xzd012022099);Natural Science Basic Research Program of Shaanxi(Grant Nos.:2023-JC-ZD-47,and 2023-JC-QN-0921);Research Project of Shaanxi Administration of Traditional Chinese Medicine(Project No.:SZY-KJCYC-2023-008);Research Project of Guangxi Administration of Traditional Chinese Medicine(Project No.:GXZYJ20230711);Basic&Clinical Sciences Integration Innovation Project of Xi'an Jiaotong University(Project No.:YXJLRH2022018).
There is increasing evidence that the activation of glucagon-like peptide-1 receptor(GLP-1R)can be used as a therapeutic intervention for cognitive disorders.Here,we have screened GLP-1R targeted compounds from Scutel...
关键词：GLP-1R agonist DIABETES Cognitive disorder MITOPHAGY Cell membrane chromatography 
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
《Acta Pharmacologica Sinica》2024年第3期480-489,共10页De-wen Kong Li-da Du Run-zhe Liu Tian-yi Yuan Shou-bao Wang Yue-hua Wang Yang Lu Lian-hua Fang Guan-hua Du 
supported by the Beijing Natural Science Foundation(7232258);the CAMS Innovation Fund for Medical Sciences(Nos.2021-/2M-1-005,2022-/2M-JB-010).
Dopaminergic neurons in the substantia nigra(SN)expressing SUR1/Kir6.2 type ATP-sensitive potassium channels(K-ATP)are more vulnerable to rotenone or metabolic stress,which may be an important reason for the selective...
关键词：Parkinson’s disease BAICALEIN SH-SY5Y cells K-ATP channels SUR1 subunit ROTENONE 
Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein被引量：1
《Acta Pharmaceutica Sinica B》2020年第8期1576-1585,共10页Wujun Dong Jun Ye Junzhuo Zhou Weijue Wang Hongliang Wang Xu Zheng Yanfang Yang Xuejun Xia Yuling Liu 
financially supported by National Science and Technology Major Project of China(Grant Nos.2018ZX09721003 and 2018ZX09711001)
Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nan...
关键词：sustained MUCUS BARRIER 
Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner被引量：5
《Signal Transduction and Targeted Therapy》2020年第1期259-261,共3页Shichao Huang Yu’e Liu Yanan Zhang Ru Zhang ChengJie Zhu Lihong Fan Gang Pei Bo Zhang Yufeng Shi 
supported by fundings from National Natural Science Foundation of China(8207112072);the Science Technology Commission of Shanghai Municipality(20S11900700 and 20400750600).
Dear Editor,The ongoing outbreak of pneumonia(coronavirus disease 2019,COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a global health emergency.Scutellaria Baicalensis Georgi ...
关键词：SCUTELLARIA acute respiratory 
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