WILD-TYPE

作品数：121被引量：282H指数：8
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相关领域：医药卫生生物学更多>>
相关作者：牟珍珍姚庆宇王丽杰袁茵李静云更多>>
相关机构：北京大学第四军医大学西京医院四川省肿瘤医院中国医学科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金天津市自然科学基金更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents被引量：1
《Signal Transduction and Targeted Therapy》2023年第1期266-275,共10页Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau 
supported by the research grant COVID19F02 and COVID19F10 awarded to Y.L.L.by the Health Bureau,the Government of Hong Kong Special Administrative Region,which was not involved in the study design,data collection,laboratory assays,statistical computation,interpretation or final conclusions of this project;This research was also supported by grants from the Health and Medical Research Fund Commissioned Research on the Novel Coronavirus Disease(COVID-19);Hong Kong SAR(COVID190115);the Theme-based Research Scheme of the Research Grants Council of the Hong Kong Special Administrative Region,China(T11-705/21-N).
The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysi...
关键词：doses NEUTRAL protective 
WT-PE:Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing被引量：7
《Signal Transduction and Targeted Therapy》2022年第5期1756-1763,共8页Rui Tao Yanhong Wang Yun Hu Yaoge Jiao Lifang Zhou Lurong Jiang Li Li Xingyu He Min Li Yamei Yu Qiang Chen Shaohua Yao 
We thank Yang Yang for providing python script for HTS data analysis.This work was supported by National Natural Science Foundation of China.No.U19A2002,No.81771220 and No.81974238.
Large scale genomic aberrations including duplication,deletion,translocation,and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer.The cu...
关键词：Cas9 NUCLEASE EDITOR 
Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters被引量：1
《Signal Transduction and Targeted Therapy》2022年第3期632-634,共3页Ya-Nan Zhang Zhe-Rui Zhang Hong-Qing Zhang Na Li Qiu-Yan Zhang Xiao-Dan Li Cheng-Lin Deng Fei Deng Shuo Shen Bing Zhu Bo Zhang 
We thank the National Key Research and Development Program of China(2018YFA0507201)for grant support.We thank the National Virus Resource center for making Omicron available.
Dear Editor,The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to disrupt global public health since its first report in December 2019,resulting in more than 380 billi...
关键词：ACUTE PATHOGENESIS RESPIRATORY 
Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route
《Signal Transduction and Targeted Therapy》2022年第1期258-269,共12页Ting Pan Ran Chen Xin He Yaochang Yuan Xiaohui Deng Rong Li Haiping Yan Shumei Yan Jun Liu Yiwen Zhang Xiantao Zhang Fei Yu Mo Zhou Changwen Ke Xiancai Ma Hui Zhang 
This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103);the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400);the Emergency Key Program of Guangzhou Laboratory(EKPG21-24);the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002);the Special Research and Development Program of Guangzhou(202008070010);the Important Key Program of NSFC⑻730060)to HZ This work was also supported by the National Natural Science Foundation of China(82102385);the National Postdoctoral Program for Innovative Talents of China Postdoctoral Science Foundation(BX20190398)to X.M;This work was also sup ported by the National Natural Science Foundation of China(81971918);Shenzhen Science and Technology Program(Grant Nos.JSGG20200225150431472 and JCYJ20200109142601702);the Pearl River S&T Nova Program of Guangzhou(201806010118);the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(2021qntd43)to T.P;This work was supported by the National Natural Science Foundation of China(32100743,82171825)to X.H.
COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2,which also can cross・transmit to many animals but not mice.Genetic modifications of SARS-CoV-2 or mice enable the mice susceptible to viral infection.A...
关键词：ELEVATED utilized adapted 
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