WILD-TYPE

作品数：121被引量：282H指数：8
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相关领域：医药卫生生物学更多>>
相关作者：牟珍珍姚庆宇王丽杰袁茵李静云更多>>
相关机构：北京大学第四军医大学西京医院四川省肿瘤医院中国医学科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金天津市自然科学基金更多>>
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Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors
《World Journal of Gastrointestinal Oncology》2025年第3期13-18,共6页Yuan Liu Xiao-Feng Li 
National Natural Science Foundation of China,No.82370569;Basic and Applied Basic Research Foundation of Guangdong Province,No.2022A1515012647;the Key Program for Science and Technology Projects of Social Development in Zhuhai,No.2220004000249(to Li XF).
This editorial discusses Wang et al's article on familial gastrointestinal stromal tumors(GISTs).We read with great interest this article concerning the diagnosis,treatment,and post-treatment management of patients wi...
关键词：Gastrointestinal stromal tumors KIT mutation Platelet-derived growth factor receptor alpha mutation Wild-type gastrointestinal stromal tumor Tyrosine kinase inhibitors Familial gastrointestinal stromal tumor syndromes Molecular characteristics Targeted therapy 
Overall survival with frontline vs subsequent anti-epidermal growth factor receptor therapies in unresectable,RAS/BRAF wild-type,leftsided metastatic colorectal cancer
《World Journal of Clinical Oncology》2025年第3期57-67,共11页Nussara Pakvisal Richard M Goldberg Chirawadee Sathitruangsak Witthaya Silaphong Satawat Faengmon Nattaya Teeyapun Chinachote Teerapakpinyo Suebpong Tanasanvimon 
BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metasta...
关键词：Metastatic colorectal cancer Anti-epidermal growth factor receptor FRONTLINE Subsequent line RAS wild-type metastatic colorectal cancer BRAF wild-type metastatic colorectal cancer Left-sided metastatic colorectal cancer Overall survival 
SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids
《Research》2025年第1期107-120,共14页Weikang Chen Xiaobing Jiang Wei Liang Haojie Bai Mingze Xu Zhe Liu Lina Yi Yanming Liu Yanxia Huang Yongxin Zhang Lixia Xu Baoshu Xie Nu Zhang Jun Yu Jing Lu Haipeng Xiao Xiaoxing Li 
supported by Guangdong Science and Technology Program(2021B1212030007)from Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response,National Natural Science Foundation of China(82372624);National Natural Science Foundation of Guangdong Province(2022A1515012430);China Postdoctoral Science Foundation(2022M723588);Medical Scientific Research Foundation of Guangdong Province(A2023439);GuangDong Basic and Applied Basic Research Foundation(2023A1515110422).
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals.However,whether and how aging brains are affected by Omicron variants in t...
关键词：brain tissue aging brains Omicron variants primary brain spheroids bss Elderly brain spheroids NEUROVIRULENCE 
The 21-base pair deletion mutant Calpain3 does not inhibit wild-type Calpain3 activity
《Genes & Diseases》2025年第1期52-55,共4页Swati Maitra Seungjae Oh Yun-Jeong Choe JiHye Kim Nam Chul Kim 
supported by grants from the Muscular Dystrophy Association and the Wallin Neuroscience Discovery Fund and the Engebretson Drug Design and Discovery Fund(to Nam Chul Kim).
Calpain3 is one of the calpain protease family members that are predominantly expressed in skeletal muscle.Lossof-function mutations in Calpain3 have been related to autosomal recessive limb-girdle muscular dystrophy ...
关键词：CATALYTIC BASE function 
Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^(G12D)and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
《Military Medical Research》2024年第6期818-838,共21页Hao-Jun Xiong Hong-Qiang Yu Jie Zhang Lei Fang Di Wu Xiao-Tong Lin Chuan-Ming Xie 
supported by the National Natural Science Foundation of China(82370631);the Talent Foundations from Army Medical University(4174C6),the Chongqing Government(CQYC20220303727)to Xie CM;the National Natural Science Foundation of China(31900449)to Xiong HJ.
Background:Kirsten rat sarcoma(KRAS)and mutant KRAS^(G12D)have been implicated in human cancers,but it remains unclear whether their activation requires ubiquitination.This study aimed to investigate whether and how F...
关键词：UBIQUITINATION Kirsten rat sarcoma(KRAS) F-box and leucine-rich repeat 6(FBXL6) PRELID2 Reactive oxygen species Extracellular signal-regulated kinase(ERK) Mammalian target of rapamycin 
First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer:real-world multicenter study
《Frontiers of Medicine》2024年第6期1026-1034,共9页Jing Li Youguo Chen Mian He Xiaoxiang Chen Hao Wen Yu Kang Kaijiang Liu Ge Lou Xipeng Wang Qinglian Wen Li Wang Zhongqiu Lin 
Although olaparib has demonstrated substantial clinical benefits as maintenance therapy in BRCA mutation-carrying women with newly diagnosed advanced ovarian cancer,its effectiveness in patients without BRCA mutations...
关键词：adverse events maintenance therapy OLAPARIB ovarian cancer progression-free survival 
Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination
《Chinese Medical Journal》2024年第21期2627-2629,共3页Yishan Li Qin Wang Lin Li Shaohua Yuan Hui Chen Rutian Li Fangcen Liu 
supported by the Natural Science Foundation of China(Nos.82203178,82272852,and 82103687);Jiangsu Provincial Key Research and Development Program(No.BE2020619);Natural Science Foundation of Jiangsu Province(No.BK20220191);Nanjing Medical Science and Technology Development Foundation(No.YKK22086).
To the Editor:Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.GISTs mostly occur in the stomach or small intestine among patients around 40-60 years of age,an...
关键词：gastrointestinal STOMACH INTESTINE 
Two different mutational types of familial gastrointestinal stromal tumors:Two case reports被引量：1
《World Journal of Gastrointestinal Oncology》2024年第9期4028-4036,共9页Xiao-Ke Wang Lu-Fan Shen Xin Yang He Su Tao Wu Peng-Xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu 
National Natural Science Foundation of China,No.82160842;Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17;General Program of the Joint Scientific Research Fund,No.23JRRA1521.
BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases...
关键词：Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA IMATINIB Treatment Case report 
Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE
《Frontiers of Chemical Science and Engineering》2024年第9期125-135,共11页Sijie Zhou Junyanrui Li Xichen Cui Ying Wang Ying-Jin Yuan 
supported by the National Key Research and Development Program of China(Grant No.2021YFC2100800);the National Natural Science Foundation of China(Grant No.22208241);China Postdoctoral Science Foundation(Grant No.2023M732591);the Key R&D Program of Shandong Province,China(Grant No.2022SFGC0102).
Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species evolution.Synthetic chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been appl...
关键词：genomic rearrangements synthetic yeast genome SCRAMBLE inter-chromosomal insertions synthetic biology 
Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart?A crystallographic,biophysical,and theoretical study被引量：1
《hLife》2024年第8期419-433,共15页Mohamed Ibrahim Xinyuanyuan Sun Vinicius Martins de Oliveira Ruibin Liu Joseph Clayton Haifa El Kilani Jana Shen Rolf Hilgenfeld 
Financial support from the German Center for Infection Research(DZIF;project FF 01.905,to R.H.);the National Institutes of Health(R35GM148261 to J.S.)is gratefully acknowledged.R.H.is also supported by the Government of Schleswig-Holstein through its Structure;Excellence Fund as well as by a close partnership between the Possehl Foundation(Lübeck)and the University of Lübeck.
During the continuing evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the Omicron variant of concern emerged in the second half of 2021 and has been dominant since November of that year.Along ...
关键词：severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) main protease Omicron molecular dynamics Pro>His mutant double mutant 
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