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GLUE: 作品数：167被引量：462H指数：12; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：熊立华卫晓婧万民李一平任立良更多>>; 相关机构：河海大学武汉市科达云石护理材料有限公司武汉大学北京师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划国家科技支撑计划教育部“新世纪优秀人才支持计划”更多>>

Modulation of microstructure and properties of Cu−Ni−Sn alloy by addition of trace Ti: 《Transactions of Nonferrous Metals Society of China》2024年第12期3978-3991,共14页Ying-lin HU Zi-luo CHENG Xiao-na LI Zhu-min LI Yuan-di HOU Min LI Mian YANG Yue-hong ZHENG Chuang DONG; support from the National Natural Science Foundation of China(No.52071052).; The segregation of Sn and discontinuous precipitation at grain boundaries are detrimental to the strength,ductility,and machinability of the Cu−Ni−Sn alloy.A strategy to solve the above problems is multi-component com...; 关键词：Cu−Ni−Sn alloy microstructure properties cluster-plus-glue-atom model segregation discontinuous precipitation enthalpic interaction

Clinically and orally compatible formulation-manufactured DDX5 (p68)-targeting molecular glue FL118 products exhibit low toxicity but high efficacy against human cancer: 《Journal of Pharmaceutical Analysis》2024年第11期1717-1720,共4页Xiang Ling Wenjie Wu Li Yan Leslie Curtin Melanie M.Farrauto Sandra Sexton Anmbreen Jamroze Changjun Yu Christos Fountzilas Dean G.Tang Fengzhi Li; Our recent breakthrough discovery demonstrated that the anticancer drug FL118 tightly binds to and then dephosphorylates and degrades the oncogenic protein DEAD-box helicase 5(DDX5),leading to the inhibition of DDX5 d...; 关键词：DDX5 FORMULATION BREAKTHROUGH

Clinical Application of Skin Wound Adhesive (Glue) in Skin Incisions: 《Journal of Clinical and Nursing Research》2024年第11期1-4,共4页Huafeng Kang; Objective:To explore the clinical application of skin wound adhesive(glue)in skin incisions.Methods:Data from 46 patients who underwent surgery in our hospital between June 2024 and August 2024 were collected,focusing...; 关键词：Skin wound adhesive(glue) Skin incision N-butyl cyanoacrylate 2-octyl cyanoacrylate

Compressive properties of glue-laminated timber circular post modified by basalt fiber reinforced polymer: 《林业工程学报》2024年第5期67-74,共8页WEI Peixing GUO Wenzhen ZHAO Mingjing GUO Zhensheng WANG Jianhe; 江苏农林职业技术学院“亚夫科技创新与服务”(2023kj11);江苏高校“青蓝工程”(2023);河南省高等学校重点科研项目(23B610009)。; Glued timber structure is one of the main forms of modern wood architecture,which has gradually developed towards mid-and high-rise buildings.Glue-laminated timber(GLT)is comprised of several laminates of parallel-to-...; 关键词：basalt fiber reinforced polymer(BFRP) GLT circular post bearing performance

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH: 《Acta Pharmaceutica Sinica B》2024年第9期4001-4013,共13页Ziqi Huang Kun Zhang Yurui Jiang Mengmeng Wang Mei Li Yuda Guo Ruolin Gao Ning Li Chenyang Wang Jia Chen Jiefu Wang Ning Liu Xiang Liu Shuangwei Liu Mingming Wei Cheng Yang Guang Yang; the National Natural Science Foundation of China(NSFC,No.82003186,82073691 and 82373134);the International Science and Technology Cooperation Project of China(No.2022YFE0133300);Ningbo Science and Technology Bureau under CM2025 Programme(2020Z092,China);Shenzhen Science and Technology Foundation(JCYJ20210324122006017,China);Tianjin Natural Science Fund(21JCQNJC01910,China);China Postdoctoral Science Foundation e Tianjin Joint Support Program(No.2023T029TJ).; Cancer stem cells(CSCs)play a pivotal role in tumor initiation,proliferation,metastasis,drug resistance,and recurrence.Consequently,targeting CSCs has emerged as a promising avenue for cancer therapy.Recently,3-phosph...; 关键词：Molecular glue Targeted protein degradation PHGDH Cancer stem cells PROTACs

靶向难成药蛋白——蛋白质降解剂的力量: 《Science Bulletin》2024年第11期1776-1797,共22页张超刘永波李广晨杨周立韩驰孙秀云盛春泉丁克饶燏; supported by the National Key R&D Program of China(2021YFA1300200,2021YFA1302100 and 2020YFE0202200);the National Natural Science Foundation of China(82125034,82330115)。; Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted,but are of great clinical significance.According to statist...; 关键词：Undruggables Targeted protein degradation PROTAC Molecule glue DAC LYTAC

Water-Excluding Underwater Glue Induced by Marangoni Effect: 《CCS Chemistry》2024年第5期1289-1299,共11页Ke Zhang Xizi Wan Zi-Yu Liu Feilong Zhang Jingwei Lu Jingxin Meng Ye Tian Haeshin Lee Lei Jiang Shutao Wang; supported by the National Key R&D Program of China(project nos.2018YFA0209500 and 2019YFA0709300);the National Natural Science Foundation of China(grant nos.21621091,21972155,21975209,22005255,22035008,52025132,and 22205244);Projects of International Cooperation and Exchanges Natural Science Foundation of China(NSFC,grant no.1A1111KYSB20200010);National Program for Special Support of Eminent Professionals and the Fundamental Research Funds for Central Universities(grant no.20720190037);the China Postdoctoral Science Foundation(grant no.2022M713225).; Marangoni effect at the two-phase interface with different surface tension as a unique mass transfer phenomenon has been widely used in daily life and industrialmanufacture.However,their marvelous liquid-driving capab...; 关键词：Marangoni effect underwater adhesion dynamic water-excluding water layer solvent diffusion

不同目标函数对新安江模型参数的敏感性和不确定性影响分析被引量：1: 《水文》2024年第2期1-7,18,共8页李悦刘冀杨少康赵心睿舒章康; 湖北省教育厅科学技术研究重点项目(D20211205);国家自然科学基金项目(51609124)。; 目标函数的选择影响流域水文模型的参数率定结果。为深入探究不同目标函数对水文模型参数的敏感性和不确定性及径流模拟结果的影响,本文以福建省金溪池潭流域日径流模拟为例,采用SCEM-UA优化算法率定三水源新安江模型,选择纳什效率系数f...; 关键词：径流模拟 Sobol敏感性分析新安江模型 GLUE 参数率定目标

Simultaneously healing cracks and strengthening additively manufactured Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3) high-entropy alloy by utilizing Fe-based metallic glasses as a glue被引量：1: 《Journal of Materials Science & Technology》2024年第12期125-137,共13页Hao Kang Kaikai Song Leilei Li Xiaoming Liu Yandong Jia Gang Wang Yaocen Wang Si Lan Xin Lin Lai-Chang Zhang Chongde Cao; National Natural Science Foundation of China(Nos.51971180,51871132,51971179 and 52271037);New R&D Institution Construction Program of Guangdong Province,China(No.2019B090905009);Shenzhen Fundamental Research Program,China(No.JCYJ20210324122203010);Shaanxi Provincial Science and Technology Program,China(No.2023-JC-ZD-23);Foreign Senior Talents Program of Guangdong Province,China and the Fundamental Research Funds for the Central Universities of China(No.D5000230131).; Solidification cracking issues during additive manufacturing(AM)severely prevent the rapid development and broad application of this method.In this work,a representative Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3) high-entropy ...; 关键词：Selective laser melting High-entropy alloys Crack healing Metallic glasses Mechanical properties

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies被引量：3: 《Acta Pharmaceutica Sinica B》2024年第2期533-578,共46页Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen; supported by the National Natural Science Foundation of China(Nos.82173668,82260676);Jiangxi Provincial Natural Science Foundation(20232BAB216131,China);the Scientific and Technological Key Projects of Guangdong Province(Nos.2021B1111110003,2019B020202002,China);the Science and Technology Projects of Ganzhou(202101094462,China);the Start-Up Foundation of Gannan Medical University(No.QD202144-2067,China).; Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g...; 关键词：EPIGENETIC Degrader PROTAC Molecularglue Hydrophobic tagging

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