Objective To investigate the characteristics of neointimal hyperplasia (NIH) in patients with in-stent restenosis (ISR) over 5 years post-drug-eluting stent(DES) implantation based on optical coherence tomography (OCT...
Supported in part by Cardiovascular Medical Research and Education Fund
BACKGROUND Pulmonary hypertension(PH) is a progressive disease with a high morbidity and mortality rate; and neointima formation leads to the irreversibility of the disease.We have previously reported that in rats, mo...
This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81171093, 81671137, and 81571126).
Reendothelialization in the aneurysm neck is pivotal to vascular repair for intracranial aneurysm after flow diverter (FD) implantation. Recombinant human stromal cell-derived factor 1α (rhSDF-1α) is a vital che...
Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endoth...
Background: Endothelial cell damage is an important pathophysiological step of restenosis after angioplasty and stenting. Cell transplantation has great therapeutic potential for endothelial recovery. We investigated...
Supported by Funds from NYMC Research Endowment Fund under the College’s intramural support program(RM);the National Institutes of Health(JEL,R01 HL111259);K23 HL098743(EDA)
AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or s...
The state-of-the-art immunosuppression drugs do not ensure indefi nite transplant survival,and most transplants are continuously lost to chronic rejection even years posttransplantation.This form of rejection is respo...
Very late stent thrombosis is a life-threatening complication of implantation of drug-eluting stent (DES). The mechanisms are still unidentified. Stent malapposition is supposed to be one debated reason. Here we rep...
This study was supported by grants from the National Natural Science Foundation of China (No. 30770899 to NIE Ru-qiong), the Natural Science Foundation of Guangdong Province (No. 8151008901000072 to NIE Ru-qiong).
Background Recent studies indicate that bone marrow-derived cells may significantly contribute to atherosclerosis, post-angioplasty restenosis and transplantation-associated vasculopathy. The responsible bone marrow ...
Optical coherence tomography (OCT) is a new imaging modality with resolution of approximately 10 pm and can be employed to visualize intracoronary characteristics. Sirolimus-eluting stents (SES) are susceptible to...