supported by the National Institutes of Health Grant (R01-AG062469);the Grantin-Aid of Research,Artistry,Scholarship program (GIA,Project 143977) at the University of Minnesota;funding from the Center for Drug Design (CDD),University of Minnesota (to SSM)。
The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that precipice.The amyloid-β(Aβ) peptides are understood to underlie the hallm...
This work was supported by the Lanzhou Science and Technology Plan Project[grant number:2018-1-104];the Special Fund Project for Guiding Science and Technology Innovation and Development in Gansu Province[grant number:2019ZX-05];the Gansu Province Colleges and Universities Industrial Support Plan Project[grant number:2020C-21].
The most severe fungal disease is postharvest gray mold,which might cause massive losses in Lanzhou lily bulbs.Some microorganism-produced volatile organic compounds(VOCs)have been proven to have antifungal action and...
Premature plant senescence induced by abiotic stresses is a major cause of agricultural losses worldwide. Tools for suppressing stress-induced plant senescence are limited. Here, we report that diacetyl, a natural com...
funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);NSFC(grant numbers 21971175 and 21572148).
This work developed an unprecedented strategy for the acetylation of alcohols and amines using diacetyl as both an acylation reagent and a photosensitizer.This environmentally friendly process exhibits excellent funct...
[Objectives] Columbus and Tsingtao Flower were selected to brew Ale beer, thereby studying the brewing characteristics of high α-acid and high β-acid content hops. [Methods] The content of diacetyl and bitterness in...
National Technology Research Program for Creating New Drugs (2009ZX09308-003 and 2011ZX09201-201-16)
Objective To investigate the chemical constituents from Aidi Injection.Methods The chemical constituents were isolated by chromatography on Sephadex LH-20 gel columns and reverse phase semi-preparative HPLC repeatedly...
The effect of metallic ions on the nitrolysis of DAPT [3,7-diacetyl-1,3,5,7-tetraazabicyclo(3.3.1)nonane] and HA (hexamine) was investigated by experimental and theoretical approaches. The combinatorial reagent, M...
supported by the National Natural Sci- ence Foundation of China (No. 30771113, 30870810)and the Program for New Century Excellent Talents in University;provided by the Caenorhabditis Genetics Center (funded by the NIH, National Center for Foundation from Research Resource)
Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin (MC)-LR also could cause neurotoxicity. Nematode Caenorhabditis elegans was explored as a model to study the neurotoxicity. In the presen...
Project supported by the National Natural Science Foundation of China (Grant Nos 19854002, 19774037 and 10274040) and the Research Fund for the Doctoral Program Foundation of Institution of Higher Education of China (Grant No 1999000327).
The first electronic structural study of the complete valence shell binding energy spectra of the antimicrobial agent diacetyl, encompassing both the outer and inner valence regions, is reported. The binding energy sp...