supported by the National Natural Science Foundation of China(82074043,82104425,82374065,and 81673626);the China Postdoctoral Science Foundation(2021M702217).
Early growth response protein 1(Egr-1)triggers the transcription of many genes involved in cell growth,differentiation,synaptic plasticity,and neurogenesis.However,its mechanism in neuronal survival and degeneration i...
Supported by the National Natural Science Foundation of China:Investigating the Mechanism of Total Saponins in Treating Gouty Arthritis Based on Toll-like Receptor/Myeloid Differentiation Factor 88/Nuclear Factor-Kappa B Signal Pathway and Nacht Leucine-Rich Repeat Protein 3-Inflammasome(No.81573670);Study on the Material Basis and Pathway of Taohong Siwu Decoction in Regulating the Release of Platelet Alpha Granules in Postpartum Blood Stasis(No.81473387);Study on the Regulatory Mechanism of Taohong Siwu Decoction on Experimental Cerebral Ischemia Angiogenesis Based on the Messenger Effect of Platelet Microparticles(No.81503291);Investigating the Material Basis and Molecular Mechanism of Taohong Siwu Decoction Against Vascular Dementia Based on Microdialysis Technology and NOD-Like Receptor Protein 3 Inflammasome Vascular Endothelial Cell Interaction(No.81903953);the Anhui Province Key Research and Development Program:Research on the Development and Preparation of Taohong Siwu Granules(No.1704a0802141)。
OBJECTIVE:To investigate the effect of Taohong Siwu decoction(桃红四物汤,TSD)on atherosclerosis in rats as well as investigate the underlying mechanism based on molecular docking.METHODS:Sixty healthy male Sprague-Daw...
The famous 1989 “cold fusion” experiment of Fleischmann and Pons is revisited and the results are discussed. It is shown that these results, which were attributed to nuclear fusion near or at room temperature but we...
This work was supported by the National Natural Science Foundation of China(81901216 and 82030036);Southwest Hospital(SWH2018BJKJ-05 and SWH2015QN13);the Chongqing Talent Program(4139Z2391).
Insufficient remyelination due to impaired oligodendrocyte precursor cell(OPC)differentiation and maturation is strongly associated with irreversible white matter injury(WMI)and neurological deficits.We analyzed whole...
Supported by the National Natural Science Foundation of China,No.81770730;and the Hunan Provincial Natural Science Fund,No.2017JJ2352.
BACKGROUND Hyporesponsiveness to erythropoiesis-stimulating agents(ESAs)is a prevalent problem in patients with chronic kidney disease.It is associated with increased morbidity and mortality in patients who undergo di...
A large number of DNA damage response proteins accumulate at the damage sites after DNA is damaged,forming repair foci which can be observed by fluorescence microscope after Immunofluorescence staining[1].With the dis...
Little is known about dysphagia after pontine infarction. In this study, we evaluated the incidence of dysphagia after isolated pontine infarction and identified the predictive factors for the occurrence of dysphagia....
supported by National Natural Science Foundation of China(81502123 and81330081);Natural Science Foundation of Anhui Province(1308085QH130);Anhui Province Nature Science Foundation in University(KJ2014A119)
OBJECTIVE Basic fibroblast growth factor(b FGF)and platelet-derived growth factor(PDGF)produced by hepatocellular carcinoma(HCC)cells are responsible for the cell growth.Accumulating evidence shows that insulin-like g...
This study was partly supported by grants from the National Natural Science Foundation of China (No. 81570373, No. 81170283, No. 81470580, and No. 81070202).
Background: Vein graft failure (VGF) is a serious complication of coronary artery bypass graft, although the mechanism remains unclear. The study aimed to investigate the effects of microRNAs (miRNAs) on the endo...