supported by National Natural Science Foundation of China (81670977, J.L. and 81800965, K.L.);Sichuan Science and Technology program (Grant no. 2017SZ0030);Fundamental Research Funds for Central University 2018SCU12016 (K.L.);China Postdoctoral Science Grant 2018M643507 (K.L.);Research Fund of West China Hospital WCHS-201705 (K.L.);Research Fund for Resins of Chinese Stomatological Association CSA-R2018-06 (K.L.);University of Maryland School of Dentistry bridging fund (H.H.K.X.);University of Maryland Baltimore seed grant (H.H.K.X.)
Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This...
partially supported by a grant from the National Natural Science Foundation of China 31371279 (to Fu Xiong);the National Natural Science Foundation of China 81371137 (to Bu-Ling Wu);the Science and Technology Program of Guangzhou 201707010301 (to Fu Xiong)
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named "amelin" or "sheathlin") is the sec...
supported by NIH R01 DE17974 (Hockin HK Xu);a scholarship from West China School of Stomatology (Chen Chen);Program for New Century Excellent Talents in University (Lei Cheng);Youth Grant of Science and Technology Department of Sichuan Province China (2014JQ0033) (Lei Cheng);a bridge fund from University of Maryland Baltimore School of Dentistry (Hockin HK Xu);a seed grant from University of Maryland Baltimore (Hockin HK Xu)
Antibacterial dimethylaminododecyl methacrylate (DMADDM) was recently synthesized. The objectives of this study were to: (1) investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans ...
supported by NIH grants DE018486 and R56 DE022789 to Jian-Quan Feng, DE023365 to Yong-Bo Lu and a scholarship from the Chinese State Scholarship Fund to Shu-Xian Lin (2010627108)
Dentin matrix protein 1(DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is cons...
supported by research funds from the Natural Science Foundation of China (No. 81130078 and No. 81000458);Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13051)
Our previous studies showed that biomodification of demineralized dentin collagen with proanthocyanidin(PA) for a clinically practical duration improves the mechanical properties of the dentin matrix and the immedia...
support from the National Natural Science Foundation of China(Nos.81170996,81070867 and 81100777);the Sichuan Province Science and Technology Innovation Team Program(2011JTD0006)
‘Bronze teeth' reflect the mechanical properties of natural teeth to a certain extent. Their mechanical properties resemble those of a tough metal, and the gradient of these properties lies in the direction from out...
supported by NIH grants Jian-Quan Feng (DE018486) and to Chun-Lin Qin (DE005092);State Key Laboratory of Oral Diseases Open Funding (SKLODOF2010-03) to Jian-Quan Feng
Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change is a direct role of DMP1 or an indir...
The present investigation assessed the effect of acid etching on marginal adaptation of white- and gray-colored mineral trioxide aggregate (MTA) to apical dentin using microcomputed tomography (micro-CT) and scann...
supported (in part) by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health
The tooth root cementum is a thin, mineralized tissue covering the root dentin that is present primarily as acellular cementum on the cervical root and cellular cementum covering the apical root. While cementum shares...
The presence of matrix metalloproteinase-2 (MMP-2) in dentin has been reported, but its distribution and activity level in mature human coronal dentin are not well understood. The purpose of this study was to determ...