1,3,4-THIADIAZOLE

作品数:47被引量:88H指数:6
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相关领域:理学更多>>
相关作者:吴黎红张久王萍李文元潘腾更多>>
相关机构:中国船舶重工集团公司山东师范大学武汉生物工程学院更多>>
相关期刊:《Chemical Research in Chinese Universities》《有机化学》《Chinese Journal of Structural Chemistry》《Journal of Environmental Sciences》更多>>
相关基金:国家自然科学基金湖北省自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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Heterocyclization of thiocarbonohydrazides:Facile synthesis of 5-unsubstituted-1,3,4-thiadiazoles
《Chinese Chemical Letters》2015年第9期1183-1186,共4页Alaa A.Hassan Fathy F.Abdel-Latif Mohamed Abdel Aziz Sara M.Mostafa Stefan Brse Martin Nieger 
2-(Hydrazinecarbothioyl)-N-substituted hydrazinecarbothioamides react with 2,3,5,6-tetrachloro-1,4-benzoquinone in high yields in a novel fast and facile method to give 5-unsubstituted-1,3,4-thiadiazole-2-amine deri...
关键词:Thiocarbonohydrazides 5-Unsubstituted 1 3 4-thiadiazol-2-amines Tetrachloro-1 4-benzoquinone X-ray crystallography 
Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties被引量:8
《Chinese Chemical Letters》2013年第4期299-302,共4页Li-Hong Shen Hong-Yu Li Hui-Xia Shang Shu-Ting Tian Yi-Sheng Lai Li-Jie Liu 
In search of novel anticancer agents, a series of N-methyl colchiceinamide derivatives (7a-7i) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by spectral analysis. Cytoto...
关键词:ColchicineN-Methyl colchiceinamide1 3 4-ThiadiazoleCytotoxicity 
Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone
《Chinese Chemical Letters》2012年第7期817-819,共3页Jie Zhao Bao Quan Chen Yan Ping Shi Yu Ming Liu Hai Chuan Zhao Ji Cheng 
supported by the National NaturalScience Foundation of China(No.20971097)
A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721,human breast cancer cell MCF-7 and ...
关键词:1 3 4-Thiadiazole derivatives Benzisoselenazolone SYNTHESIS Antitumor activity 
Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole被引量:11
《Chinese Chemical Letters》2012年第5期549-552,共4页Xin Jian Song Zheng Chao Duan Yu Shao Xing Gao Dong 
the Natural Science Foundation of Hubei Province(No2011CDB087);Scientific Research Fund of Hubei Provincial Education Department(NoD20111904);Open Fund of Key Laboratory of Biological Resources Protection and Utilization of Hubei Province(NoPKLHB1102)for generous financial support
A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a facile microwave-assisted procedure,including the cyclization of 2-aminothiophene-3-carbonitrile ...
关键词:Thieno[2.3-d]pyrimidine 1 3 4-Thiadiazole TRIFLUOROMETHYL Microwave-assisted synthesis 
Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents被引量:6
《Chinese Chemical Letters》2011年第9期1036-1038,共3页Xin Jian Song Yu Shao Xing Gao Dong 
the National Nature Science Foundation of Hubei Province(No.2008CDB016);the Scientific Research Fund of Hubei Provincial Education Department(No.D20111904)
A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole is described. This protocol presented such advantages as short reaction time,...
关键词:Pyrazolo[3 4-d]pyrimidine 1 3 4-THIADIAZOLE Microwave-assisted synthesis Antitumor activity 
A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent被引量:1
《Chinese Chemical Letters》2010年第10期1149-1152,共4页Harish Rajak Chinmay K.Behera Raiesh S.Pawar Pradeep K.Singour Murli Dhar Kharya 
In pursuit for better antiepileptic drug and the importance of semicarbazones and 2,5-disubstituted 1,3,4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-l-benzofuran-3-yl)methyl]-l...
关键词:1 3 4-Thiadiazoles SEMICARBAZONES Anticonvulsant activity 
Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles被引量:1
《Chinese Chemical Letters》2010年第3期293-296,共4页Li, Ying Jun Liu, Li Jun Jin, Kun Xu, Yong Ting Sun, Su Qin 
supported by the Education Office of Liaoning Province(No.2008345)
A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5- [2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with vario...
关键词:Triazolo-thiadiazoles SYNTHESIS Bioactivity 
Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400被引量:1
《Chinese Chemical Letters》2010年第3期301-304,共4页Wang, Xi Cun Ding, Xiao Mei Wang, Sheng Qing Chen, Xue Fei Quan, Zheng Jun 
support from the Natural Science Foundation of Gansu Province(No.3ZS061- A25-019);the Scientific Research fund of Gansu Provincial Education Department(No.0601-25)
An environmental benign procedure for synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles has been developed by reaction of 2-amino-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with formic acid in PEG-400.The...
关键词:2-(N-Formyl)-5-aryl/aryloxymethyl-1 3 4-thiadiazoles 2-Amino-5-aryl/aryloxymethyl-1 PEG-400 Synthesis 
Synthesis and evaluation of in vitro antibacterial activity of novel 2,5-disubstituted-l,3,4-thiadiazoles from fatty acids被引量:7
《Chinese Chemical Letters》2008年第12期1427-1430,共4页Mudasir R.Banday Abdul Rauf 
A series of new 1-(alkenoyl/hydroxyalkenoyl)-4-benzoyl-thiosemicarbazides 2a-d and 2-benzamide-5-alkenyl/hydroxyalk- enyl-1,3,4-thiadiazoles 3a-d were synthesized from fatty acid hydrazides. Structure of all these c...
关键词:Aroylthiosemicarbazide 1 3 4-THIADIAZOLE Antibacterial activity 
Synthesis and antitumor activity of N^1-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives被引量:4
《Chinese Chemical Letters》2008年第11期1281-1284,共4页Kai Bo Zheng Jun He Jie Zhang 
A new series of N^1-acetylamino-(5-alkyl/aryl- 1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical wer...
关键词:5-Fluorouracil derivatives 1 3 4-THIADIAZOLE SYNTHESIS ANTITUMOR 
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