With the introduction of various heterocyclic rings at the benzene part of anthranilic diamides, a series of N-pylidylpyrazolecarboxamide derivatives containing isoxazole, isoxazoline and 1,3,4-thiadiazole rings was d...
Supported by the National Natural Science Foundation of China(No.81373281), the Program for New Century Excellent Talents in Universities of China(No.NCET-12-0337) and the Shandong Natural Science Foundation for Distinguished Young Scholars, China(No.JQ201319).
Twenty-two novel 1,3,4-thiadiazole derivatives were synthesized using different aromatic acids as starting materials, followed by cyclization, coupling and deprotection reaction. The structures of all the target compo...
To find new lead compounds with high antifungal activity, a series of new thiourea derivatives containing 1,3,4-thiadiazole and thioether skeleton was designed via linking the active sub-structures. The target compoun...
Supported by the National Natural Science Foundation of China(No.20971097) and the Tianjin Municipal Natural Science Foundation, China(No. 13JCYBJC24500).
A series of novel 1,3,4-thiadiazole derivatives possessing benzisoselenazolone scaffold were designed and synthesized, and their antitumor activities against human cervix adenocarcinoma(HeLa), human liver cancer cel...
Dihydro-3-hydrozinocarbonyl-6-pyridazinone(compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate. A series of N-aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) thiosemicarbazides 3a_3f were ...
By ring-closure of 1-nicotinyl-4-arylthiosemicarbazides under the catalysis of concentrated sulfuric acid or mercuric acetate, a series of 2-(3-pyridyl)-5-arylarnino-1,3,4-thiadiazoles and 2-(3-pyridyl)-5-ary-lamino-1...