ANTAGONISTS

作品数：143被引量：505H指数：12
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Comparative pharmacophore modeling of human adenosine receptor A1 and A3 antagonists
《Science China Chemistry》2012年第11期2407-2418,共12页XU ZheJun CHENG FeiXiong LI Jie ZHOU YaDi SU Ni LI WeiHua LIU GuiXia TANG Yun 
supported by the National Natural Science Foundation of China (21072059);the Program for New Century Excellent Talents in University (NCET-08-0774);the 111 Project (B07023);the Shanghai Committee of Science and Technology (11DZ2260600);the Fundamental Research Funds for the Central Universities (WY1113007);the National S&T Major Project of China ( 2009ZX09501-001)
Adenosine receptors are promising therapeutic targets in drug discovery. In this study, three-dimensional pharmacophore mod- els of human adenosine receptor A1 and A3 antagonists were developed based on 26 and 23 dive...
关键词：pharmacophore modeling adenosine receptors ANTAGONISTS enrichment factor simulated virtual screening 
EGFR/cell membrane chromatography-online-high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Radix Angelicae Pubescentis被引量：5
《Science China Chemistry》2010年第11期2357-2362,共6页SiCen Wang Meng Sun YanMin Zhang Jie Zhang LangChong He 
supported by the National Natural Science Foundation of China (30730110);Program for New Century Excellent Talents in University (NCET-08-0437)
The intracellular kinase domains of the epidermal growth factor receptor(EGFR) in some tumor cells are significant targets for drug discovery.We have developed a new EGFR cell membrane chromatography(EGFR/CMC)-online-...
关键词：EGFR cell membrane chromatography high performance liquid chromatography/mass SPECTROMETRY ANTI-EGFR ANTAGONISTS RADIX Angelicae Pubescentis 
SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE
《Science China Chemistry》1991年第2期201-208,共8页刘克良 何炳林 萧绍博 夏启明 方溪 王忠义 
This work was supported in part by grants from United Nations Fund for Population Activities (UNFPA) and State Family Planning Commission of China.
<正> Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5...
关键词：NEW ANTAGONISTS of LHRH antiovulatoty activity SOLID-PHASE SYNTHESIS of peptides 
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