supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).
Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheime...