L-THYROXIN

作品数：3被引量：17H指数：2
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Cellular mechanisms of reduced sarcoplasmic reticulum Ca^2＋ content in L-thyroxin-induced rat ventricular hypertrophy
《Acta Pharmacologica Sinica》2008年第4期430-436,共7页Lai-jing SONG Guan-lei WANG Jie LIU Qin-ying QIU Jing-hua OU Yong-yuan GUAN 
Project supported by the National Natural Science Foundation of China （№ 30271503 and No 30730105） and by Science Foundation of Ministry of Education in China （№ 20050558072）Acknowledgments We thank Prof Jian-xin SHEN （Department of Physiology, University of Shan Tou） and Yan-qiu FENG （Department of Biomedical Engineering, The Southern Medical University） for their help with the Ca^2＋ spark recording.
Aim： To examine how the sarcoplasmic reticulum （SR） Ca^2＋ content changes and the underlying mechanism in L-thyroxin-induced cardiac hypertrophy. Methods： Echocardiography was used to confirm the establishment of...
关键词：left ventricular hypertrophy sarcoplasmic reticulum Ca^2＋ release Ca2＋-ATPase 
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017被引量：10
《Acta Pharmacologica Sinica》2007年第6期773-782,共10页Tao NA Zhi-jiang HUANG De-zai DAI Yuan ZHANG Yin DAI 
the National Natural Science Foundation of China(№ 30572193 and 30230170)
Aim： The occurrence of ventricular fibrillation （VF） is dependent on the deterioration of channelopathy in the myocardium. It is interesting to investigate molecular changes in relation to abrupt appearance of VF o...
关键词：sudden cardiac death ventricular fibrillation ENDOTHELIN FKBPI2.6 SERCA2A proteinkinase A CPU86017 cardiomyopathy L-THYROXIN endothelin-converting enzyme 
Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy被引量：7
《Acta Pharmacologica Sinica》2004年第3期347-351,共5页Xiao-dongWU De-zaiDAI Qiu-pinZHANG FengGAO 
Project supported by the National Natural Science Foundationof China (No 39670835).
AIM: To study the alteration in the mRNA level of cardiac ryanodine receptor 2 (RyR2) and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) in L-thyroxin-induced hypertrophy. METHODS: L-thyroxin (500 g/kg) daily was inj...
关键词：heart HYPERTROPHY ARRHYTHMIA ryanodine receptors Ca2+-transporting ATPase L-THYROXIN PROPRANOLOL VERAPAMIL reversed transcriptase polymerase chain reaction 
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