PHARMACOMETRICS

作品数：7被引量：13H指数：2
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相关机构：皖南医学院弋矶山医院更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Pediatrics》《Journal of Chinese Pharmaceutical Sciences》《Journal of Pharmaceutical Analysis》更多>>
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Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer:a pooled pharmacometrics analysis
《Acta Pharmacologica Sinica》2024年第10期2212-2225,共14页Hao-ran Dai Yang Yang Chen-yu Wang Yue-ting Chen Yi-fan Cui Pei-jing Li Jia Chen Chen Yang Zheng Jiao 
This study aimed to analyze potential ethnic disparities in the dose-exposure-response relationships of trilaciclib,a first-in-class intravenous cyclin-dependent kinase 4/6 inhibitor for treating chemotherapy-induced ...
关键词：trilaciclib small cell lung carcinoma PHARMACOKINETICS population characteristics dose-response relationship ETHNICITY 
Quantitative assessment of the relevance of organic-aniontransporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics
《Journal of Pharmaceutical Analysis》2023年第6期660-672,共13页Ji-Hun Jang Seung-Hyun Jeong Yong-Bok Lee 
Fexofenadine is useful in various allergic disease treatment.However,the pharmacokinetic variability information and quantitative factor identification of fexofenadine are very lacking.This study aimed to verify the v...
关键词：OATP1B1 OATP2B1 FEXOFENADINE Population pharmacometrics Genetic polymorphism 
Pharmacometrics of nutraceutical sulforaphane and its implications in prostate cancer prevention
《Journal of Chinese Pharmaceutical Sciences》2016年第1期12-22,共11页Sujit Nair Ah-Ng Tony Kong 
Institutional funds from Amrita Vishwa Vidyapeetham University,India,and Rutgers;the State University of New Jersey,USA;RO1 CA118947 and RO1 CA152826 from the National Institutes of Health(NIH),USA
Sulforaphane(SFN), found in broccoli and other cruciferous vegetables, has a beneficial effect in chemoprevention of prostate cancer, whose incidence and associated mortality have gradually increased worldwide. There ...
关键词：PHARMACOMETRICS Pharmacokinetics Quantitative systems pharmacology Target engagement Metabolism PHARMACOGENOMICS Chemoprevention SULFORAPHANE ISOTHIOCYANATE Prostate cancer 
Dosage individualization in children:integration of pharmacometrics in clinical practice
《World Journal of Pediatrics》2014年第3期197-203,共7页Wei Zhao Stéphanie Leroux Evelyne Jacqz-Aigrain 
supports from the European commission for their work in pediatric clinical pharmacology(FP7 Treat infection in neonates TINN1,grant agreement no.223614,FP7 Treat infection in neonates TINN2,grant agreement no.260908,FP7 Global research in paediatrics GRIP,grant agreement no.261060,FP7 NeoVanc,grant agreement no.602041)
Background:Children are in a continuous and dynamically changing state of growth and development.A thorough understanding of developmental pharmacokinetics(PK)and pharmacodynamics(PD)is required to optimize drug thera...
关键词：developmental pharmacokinetics developmental pharmacology pediatric pharmacology personalized therapy PHARMACOMETRICS quantitative pharmacology 
Population Pharmacokinetics of UCN-01
《Journal of Cancer Therapy》2013年第10期1513-1519,共7页Charlene A. Baksh Martin J. Edelman Edward A. Sausville William D. Figg Hao Zhu Kenneth S. Bauer 
UCN-01 (7-Hydroxystaurosporine) is an investigational anticancer agent that is currently being evaluated as targeted therapy in phase II clinical studies. The aims of this work were to describe the population pharmaco...
关键词：PHARMACOKINETICS UCN-01 7-Hydroxystaurosporine PHARMACOMETRICS POPULATION Modeling Phase I CLINICAL PHARMACOLOGY 
Pharmacometrics： a quantitative tool of pharmacological research被引量：2
《Acta Pharmacologica Sinica》2012年第11期1337-1338,共2页Qing-shan ZHENG Lu-jin LI 
Pharmacometrics is an interdisciplinary science with tre- mendous potential to influence decision making through the construction of mathematical and statistical models combined with graphical methods that define, cha...
定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域被引量：11
《中国临床药理学与治疗学》2008年第5期481-493,共13页Jeffrey S Barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰 谢海棠 孙瑞元 
尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其...
关键词：定量药理学 关键路径 国立卫生研究院(NIH)路线图 教育 临床药理学(Pharmacometrics) 
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