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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis
《Chinese Medical Journal》2024年第2期181-189,共9页Fangming Liu Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing Zhang 
supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-1-I2M-018);the Haihe Laboratory of Cell Ecosystem Innovation Fund(No.22HHXBSS00012);the National Natural Science Foundation of China(Nos.81730078 and 81872287)
Background:Liver cancer is largely resistant to chemotherapy.This study aimed to identify the effective chemotherapeutics forβ-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin be...
关键词：Liver cancer β-catenin METHOTREXATE Nucleotide synthesis Chemotherapy 
Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population被引量：2
《Chinese Medical Journal》2011年第18期2863-2867,共5页LU Xiao-lan ZHOU Xu-jie GUO Jian-ping JIA Ru-lin ZHAO Yi JIANG Quan LIU Xiang-yuan LIU Yi SUN Ling-yun ZHANG Hong LI Zhan-guo 
This work was supported by grants from the Major State Basic Research Development Program of China （973 Program） （No. 2010CB529100） and Key Program of the National Natural Science Foundation of China （No. 81030057）.
Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis （RA） in Caucasian populations. The aim of this study was to investigate the effect of rs5...
关键词：rheumatoid arthritis PRDM1/ATG5 genetic association Chinese Han population 
Detection and evaluation of the mutations of embB gene in etham butol-susceptible and resistant Mycobacterium tuberculos isisolates from China被引量：4
《Chinese Medical Journal》2005年第20期1739-1741,共3页WU Xue-qiong LIANG Jian-qin ZHANG Jun-xian LU Yang LI Hong-min ZHANG Guang-yu YAN Guo-rui DING Bei-chuan 
This research was supported by the Army Research Foundation forthe Outstanding Person with Ability (No.01J020).
The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therap...
关键词：drug resistance ETHAMBUTOL polymerase chain reaction polymorphism single-stranded conformational Mycobacterium tuberculosis 
Characteristics of mRNA levels of hepatic key enzymes in cholesterol metabolism of genetically gallstone-susceptible mice被引量：5
《Chinese Medical Journal》2004年第8期1259-1261,共3页许国强 赵力 
关键词：cholesterol gallstone biliary cholesterol hypersecretion HMGCoAr C7h LDLR ACAT gene expression 
E test for studying in vitro activity of seven antimicrobial agents against penicillin-susceptible and penicillin-resistant pneumococci被引量：3
《Chinese Medical Journal》2000年第7期52-55,共4页李家泰 张烨 陈亦芳 郝凤兰 陈扬 
To evaluate the comparative activity of seven oral antimicrobial agents against 100 strains of Streptococcus pneumoniae (S pneumoniae) Methods Total 100 strains of S pneumoniae were collected from gener...
关键词：Streptococcus pneumoniae penicillin resistance amoxicillin/clavulanate E test minimum   inhibitory concentration community acquired pneumoniae 
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