CYCLOTIDES

作品数:3被引量:9H指数:2
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相关领域:生物学更多>>
相关作者:王伟孔建强程克棣杜国华更多>>
相关机构:中国医学科学院北京协和医学院更多>>
相关期刊:《Science Bulletin》《Science China Chemistry》《Chinese Chemical Letters》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Discovery, structure,and chemical synthesis of disulfide-rich peptide toxins and their analogs被引量:3
《Chinese Chemical Letters》2018年第7期1033-1042,共10页Ge-Min Fang Xiao-Xu Chen Qian-Qian Yang Liang-Jing Zhu Ning-Ning Li Hai-Zhu Yu Xiang-Ming Meng 
supported by National Natural Science Foundation of China (No. 21778001)
Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood ...
关键词:Peptide toxins CONOTOXINS CYCLOTIDES Disulfide mimics Chemical synthesis 
Chemical synthesis of a cyclotide via intramolecular cyclization of peptide O-esters被引量:5
《Science China Chemistry》2012年第1期64-69,共6页ZHENG Ji-Shen CHANG Hao-Nan SHI Jing LIU Lei 
supported by the National Natural Science Foundation of China(20932006,91013007);the National Basic Research Program of China(973 Program)(2011CB965300)
Cyclotides constitute a fascinating family of circular proteins containing ca.30 amino acid residues.They have a unique cyclic cysteine knot topology and exhibit remarkable thermal,chemical and enzymatic stabilities.T...
关键词:CYCLOTIDES chemical synthesis peptide O-ester native chemical ligation MACROLACTAMIZATION 
Application of a TLC chemical method to detection of cyclotides in plants被引量:2
《Chinese Science Bulletin》2008年第11期1671-1674,共4页XU WenYan TANG Jun JI ChangJiu HE WenJun TAN NingHua 
the National Natural Science Foundation of China (Grant No. 30725048);Foundation of the West Light Program of Chinese Academy of Sciences
Iodine, Dragendorff's reagent, ninhydrin and Coomassie brilliant blue G-250 reagents were used to detect cyclotides from proteins, cyclopeptides, linear-peptides and amino acids in the thin layer chromatography (TLC)....
关键词:薄层色谱法 植物生物化学 蛋白质 大环寡肽 
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