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CONOTOXINS: 作品数：13被引量：16H指数：3; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：余晓东更多>>; 相关机构：重庆师范学院海南大学更多>>; 相关期刊：《Journal of Marine Science》《Asian Pacific Journal of Tropical Biomedicine》《Bulletin of the Chinese Academy of Sciences》《Science Bulletin》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划重庆市科委基金更多>>

Research Progress on the Influence of Structural Changes inμ-Conotoxins on Sodium Channel Receptors: 《Agricultural Biotechnology》2023年第6期99-105,共7页Chengzhang LIN Yanling LIAO Jiao CHEN Bingmiao GAO; Supported by Special Scientific Research Project of the Hainan Academician Innovation Platform,China(YSPTZX202132);Hainan Provincial Natural Science Foundation,China(820RC636);Hainan Provincial Key Point Research and Invention Program,China(ZDYF2022SHFZ309).; The voltage-gated sodium channel(Na v)is widely present in mammals and can generate cell action potentials,which are related to many diseases.Theμ-Conotoxins(μ-CTx)isolated from the venom of cone snails can specific...; 关键词：μ-Conotoxins voltage-gated sodium channel homologous modeling structure-activity relationship

Mass Spectrometry-based Sequencing of Venom Peptides(Conotoxins)from Vermivorous Cone Snail,Conus Loroisii:Toxicity of its Natural Venom: 《Journal of Marine Science》2021年第1期39-47,共9页Humaira Saleh Syed Rishimol R Arun Kumar J M Masilamani Selvam Rajesh R P; Conus loroisii is a marine vermivorous snail found profusely in the southern seas of India.They harbor several toxic peptide components commonly called as‘conotoxins’.In this study,we have identified and sequenced f...; 关键词：Conus loroisii CONOTOXINS TOXICITY Mass spectrometry

Isolation and characterization of five novel mini-M conotoxins from the venom of mollusk-hunter snail Conus bandanus: 《Asian Pacific Journal of Tropical Biomedicine》2020年第8期343-352,共10页Nguyen Bao Jean-Pière LE CAER Phan Thi Khanh Vinh; funded by Vietnam National Foundation for Science and Technology Development(NAFOSTED)under grant number 106-NN.02-2015.14; Objective:To determine the new M-superfamily conotoxins from molluscivorous snail Conus bandanus in Vietnam.Methods:Conus bandanus venom was fractionated and purified on HPLC system with an analytical reversed-phase C...; 关键词：Mini-M conotoxin Conus bandanus Cone snail venom

Characterization of α-conotoxin TxIB and TxID for smoking cessation and drug rehabilitation: 《中国药理学与毒理学杂志》2018年第9期711-713,共3页ZHANGSUN Dong-ting ZHU Xiao-peng ZHANGSUN Man-qi WU Yong LI Xiao-dan Sean CHRISTENSEN Quentin KAAS Peta J HARVEY David J CRAIK J Michael MCINTOSH LUO Su-lan; Nicotinic acetylcholine receptors(nAChRs) are widely distributed ligand gated ion channels throughout the peripheral and central nervous systems of mammals.There are 16 different n AChR subunits,α1-α7,α9,α10 and ...; 关键词：ACETYLCHOLINE RECEPTORS smokingcessation DRUG REHABILITATION α-conotoxins

Discovery, structure,and chemical synthesis of disulfide-rich peptide toxins and their analogs被引量：3: 《Chinese Chemical Letters》2018年第7期1033-1042,共10页Ge-Min Fang Xiao-Xu Chen Qian-Qian Yang Liang-Jing Zhu Ning-Ning Li Hai-Zhu Yu Xiang-Ming Meng; supported by National Natural Science Foundation of China (No. 21778001); Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood ...; 关键词：Peptide toxins CONOTOXINS CYCLOTIDES Disulfide mimics Chemical synthesis

Preparation of Conotoxin MrVIB by Genetic Engineering Technology: 《Agricultural Biotechnology》2017年第4期28-31,37,共5页Weiwei GUAN Jie HOU Xia ZHONG Na WEI Junqing ZHANG Bingmiao GAO; Supported by Natural Science Foundation of China(81560611);Natural Science Foundation of Hainan Province(No.317170); [ Objective] The disulfide-rich conotoxin MrV1B was produced by simple and fast genetic engineering method, to find new efficient ways for the synthesis of natural active conotoxins. [Method] Primers of conotoxin gene...; 关键词：CONOTOXINS Escherichia coli Genetic Engineering Recombinant Expression Separation and Purification

Chemical synthesis and characterization of two α4/7-conotoxins被引量：2: 《Acta Biochimica et Biophysica Sinica》2010年第10期745-753,共9页Can Peng Weihua Chen Tanya Sanders Geoffrey Chew Jing Liu Edward Hawrot Chengwu Chi; α-Conotoxins are small disulfide-constrained peptides that act as potent and selective antagonists on specific subtypes of nicotinic acetylcholine receptors （nAChRs）. We previously cloned two α-conotoxins, Mrl.1 f...; 关键词：CONUS α4/7-conotoxin nicotinic acetylcholinereceptor ANALGESIC

cDNA cloning of conotoxins with framework XII from several Conus species被引量：4: 《Acta Biochimica et Biophysica Sinica》2010年第9期656-661,共6页Zhuguo Liu Zheng Yu Na Liu Chongjia Zhao Jie Hu Qiuyun Dai; In our efforts for cloning novel I2-superfamily conotoxins using the signal peptide sequence, we identified a novel conotoxin Lt12.4 from Conus litteratus. This gene has a framework XII （-C-C-C-C-CC-C-C-）, which is ...; 关键词：framework XII CONOPEPTIDES cDNA clone CONUS E-conotoxins

Two Potent α3/5 Conotoxins from Piscivorous Conus achatinus被引量：5: 《Acta Biochimica et Biophysica Sinica》2007年第6期438-444,共7页Li LIU Geoffrey CHEW Edward HAWROT Chengwu CHI Chunguang WANG; Every cone snail produces a mixture of different conotoxins and secretes them to immobilize their prey and predators, α3/5 Conotoxins, isolated from fish-hunting cone snails, target muscle nicotinic acetylcholine rec...; 关键词：cone snail α3/5 conotoxin disulfide bond nicotinic acetylcholine receptor

Conotoxins Are Purified and Cloned: 《Bulletin of the Chinese Academy of Sciences》2006年第2期82-82,共1页; A group of CAS scientists have succeeded in purifying many conotoxins 2nd cioning more than 100 new genes from six species of cone snails living in waters off the coast of the South China Sea. paving the way for the d...; 关键词：无性繁殖纯化蜗牛神经性疼痛麻醉

CONOTOXINS