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作品数：378被引量：889H指数：14
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Genetic regulation of m^(6)A RNA methylation and its contribution in human complex diseases
《Science China(Life Sciences)》2024年第8期1591-1600,共10页Kexuan Chen Jiuhong Nan Xushen Xiong 
supported by the National Natural Science Foundation of China(32370609 and 92353301 to X.X.);funding from Liangzhu Laboratory at Zhejiang University and the State Key Laboratory of Transvascular Implantation Devices at Zhejiang University.
N6-methyladenosine(m^(6)A)has been established as the most prevalent chemical modification in message RNA(mRNA),playing an essential role in determining the fate of RNA molecules.Dysregulation of m^(6)A has been revea...
关键词：m^(6)A disease genetics m^(6)A-QTL GWAS 
Unique characteristics of the genetics epidemiology of amyotrophic lateral sclerosis in China被引量：7
《Science China(Life Sciences)》2019年第4期517-525,共9页Qianqian Wei Xueping Chen Yongping Chen Ruwei Ou Bei Cao Yanbing Hou Lingyu Zhang Hui-Fang Shang 
supported by the funding of the National Natural Science Foundation of China(81371394);the National Key Research and Development Program of China(2016YFC0901504)
Continual discoveries of new genes and unraveling the genetic etiology in amyotrophic lateral sclerosis(ALS) have provided greater insight into the underlying pathogenesis in motor neuron degeneration, as well as faci...
关键词：amyotrophic lateral SCLEROSIS gene mutation single NUCLEOTIDE POLYMORPHISMS 
Current perspectives on in vitro maturation and its effects on oocyte genetic and epigenetic profiles被引量：10
《Science China(Life Sciences)》2018年第6期633-643,共11页Cuiling Lu Yaoyao Zhang Xiaoying Zheng Xueling Song Rui Yang Jie Yan Huailiang Feng Jie Qiao 
supported by the National Natural Science Foundation of China(81300456);the Joint Research Fund for Overseas Natural Science of China(31429004)
In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovari...
关键词：in vitro maturation oocyte fertility genetics epigenetics 
Erratum to: Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics
《Science China(Life Sciences)》2015年第12期1306-1306,共1页JIN YiShi 
Erratum to:SCIENCE CHINA Life Sciences,November 2015 Vol.58 No.11:1084–1088doi:10.1007/s11427-015-4962-9In the first paragraph of the manuscript,the name of Charles Harrington was printed in error,should be Charles S...
关键词：Harrington genetics regeneration printed 
Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics被引量：3
《Science China(Life Sciences)》2015年第11期1084-1088,共5页JIN YiShi 
support from the National Institute of Health;the Howard Hughes Medical Institute of the United States of America
Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signal...
关键词：presynaptic active zone DLK kinase microtubule dynamics EFA-6 RPM-1 SYD-2 Liprin ubiquitin E3 ligase axoninjury laser axotomy 
Autism genetics: Methodological issues and experimental design被引量：1
《Science China(Life Sciences)》2015年第10期946-957,共12页Roberto SACCO Carla LINTAS Antonio M.PERSICO 
supported by the Italian Ministry for University,Scientific Research and Technology;the Italian Ministry of Health,the Fondazione Giuseppe e Mafalda Luce(Milan,Italy);Autism Aid ONLUS(Naples,Italy);the Autism Speaks Foundation(Princeton,NJ);the Autism Research Institute(San Diego,CA);the European Union(IMI project EU-AIMS)
Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals...
关键词：autistic disorder ENDOPHENOTYPE genetic association GENETICS pervasive developmental disorders 
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