ENDOPHENOTYPE

作品数：9被引量：7H指数：2
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inMTSCCA:An Integrated Multi-task Sparse Canonical Correlation Analysis for Multi-omic Brain Imaging Genetics
《Genomics, Proteomics & Bioinformatics》2023年第2期396-413,共18页Lei Du Jin Zhang Ying Zhao Muheng Shang Lei Guo Junwei Han 
supported in part by the STI2030-Major Projects(Grant No.2022ZD0213700);the National Natural Science Foundation of China(Grant Nos.62136004,61973255,and 61936007);the Natural Science Basic Research Program of Shaanxi(Grant No.2020JM-142);the Innovation Foundation for Doctor Dissertation at Northwestern Polytechnical University,China(Grant No.CX2023062).
Identifying genetic risk factors for Alzheimer's disease(AD)is an important research topic.To date,different endophenotypes,such as imaging-derived endophenotypes and proteomic expression-derived endophenotypes,have s...
关键词：Brain imaging genetics Multi-omic endophenotype Cross-endophenotype association Genetic risk factor Medical imageanalysis 
Autism genetics: Methodological issues and experimental design被引量：1
《Science China(Life Sciences)》2015年第10期946-957,共12页Roberto SACCO Carla LINTAS Antonio M.PERSICO 
supported by the Italian Ministry for University,Scientific Research and Technology;the Italian Ministry of Health,the Fondazione Giuseppe e Mafalda Luce(Milan,Italy);Autism Aid ONLUS(Naples,Italy);the Autism Speaks Foundation(Princeton,NJ);the Autism Research Institute(San Diego,CA);the European Union(IMI project EU-AIMS)
Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals...
关键词：autistic disorder ENDOPHENOTYPE genetic association GENETICS pervasive developmental disorders 
Schedule-Induced Polydipsia:Searching for the Endophenotype of Compulsive Behavior
《World Journal of Neuroscience》2014年第3期253-260,共8页Pilar Flores Ana Sanchez-Kuhn Ana Merchan Olga Vilches Sergio Garcia-Martin Margarita Moreno 
funded by a grant from the Ministerio de Economia y Competitividad,Spanish Government(PSI2012-31660).
The development of excessive and persistent drinking under intermittent food-reinforcement schedules, known Schedule-induced polydipsia (SIP), has been proposed as a successful animal model to study compulsive behavio...
关键词：COMPULSIVITY ENDOPHENOTYPE Schedule-Induced Polydipsia Obsessive-Compulsive Disorder SCHIZOPHRENIA 
The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population被引量：3
《Neural Regeneration Research》2012年第25期1985-1991,共7页Xinrong Li Ning Sun Yong Xu Yanfang Wang Suping Li Qiaorong Du Juyi Peng Jinxiu Luo Kerang Zhang 
supported by the National Natural Science Foundation of China,No. 30770770,30971054,and81171290;Science Foundation for the Youth of Shanxi,No.2011021036-1
The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder. Consequently, the norepinephrine transporter gene is an attractive candidate in...
关键词：Norepinephrine transporter major depressive disorder quantitative trait locus gene polymorphism retardation symptoms Hamilton Depression Scale ENDOPHENOTYPE single nucleotidepolymorphism pathogenesis 
Endophenotype strategies for the study of neuropsychiatric disorders: A quest被引量：1
《Chinese Science Bulletin》2011年第32期3359-3360,共2页CHAN~Raymoncl Chor-kiu GOTTESMAN Irving. I FU Xiao-Lan 
The identification of genes that contribute to the susceptibilities to complex neuropsychiatric disorders such as schizophrenia, major depression and bipolar disorders has not been as successful using conventional gen...
关键词：神经行为 精神障碍 表型 相关基因 精神分裂症 精神疾病 临床症状 遗传方法 
Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes被引量：2
《Chinese Science Bulletin》2011年第32期3376-3381,共6页MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton 
The Autism Research Group in the Department of Psychiatry University of Hong Kong is grateful for donation funding from ING Asia/Pacific
The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of gene...
关键词：神经疾病 似然估计 审查工作 解剖 精神分裂症 稳定 质数 进修 
Why endophenotype development requires families被引量：2
《Chinese Science Bulletin》2011年第32期3382-3384,共3页GLAHN David C BLANGERO John 
Endophenotypes are heritable quantitative traits that are associated with disease liability, can be measured in both affected and unaffected individuals, and provide much greater power to localize and identify risk ge...
关键词：家庭成员 稳定 精神疾病 遗传基础 数量性状 成像测量 生物标志物 神经管 
Statistical issues and approaches in endophenotype research被引量：2
《Chinese Science Bulletin》2011年第32期3403-3408,共6页SHAM Pak Chung CHERNY Stacey S HALL Mei-Hua 
supported by the Hong Kong Research Grants Council General Research Fund (HKU 766906M and HKU 774707M);the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI);the University of Hong Kong (HKU) Strategic Research Theme of Genomics, HKU Small Project Funding (201007176248);the National Institute of Mental Health of the USA (1K01MH086714)
The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype sho...
关键词：统计问题 稳定 遗传疾病 COM组件 复杂疾病 组成部分 模型估计 统计方法 
Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in China's Mainland: An example from neurological soft signs for neuropsychiatric disorders被引量：3
《Chinese Science Bulletin》2011年第32期3409-3415,共7页CHAN Raymond C K 
supported partially by the Key Laboratory of Mental Health,Institute of Psychology, Project-Oriented Hundred Talents Programme (O7CX031003);the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131);National Natural Science Foundation of China (30770723);National Outstanding Young Investigator Award (81088001);a grant from National Basic Research Programme of China (973 Program) (2007CB512302)
Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional ex...
关键词：精神障碍 中国大陆 神经 茅根 信息 人力 多维表达式 ICD 
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